Vernonia amygdalina : A folkloric herb with anthelminthic properties

Oyeyemi, Ifeoluwa T.; Akinlabi, Akinbiyi A.; Adewumi, Aderiike; Aleshinloye, Abimbola O.; Oyeyemi, Oyetunde T.

doi:10.1016/j.bjbas.2017.07.007

Cited by 65 publications

(58 citation statements)

References 82 publications

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“…The reduction of worm burden and temporary relief from related gastrointestinal upset has been linked to the ingestion of the bitter pith of V. amygdalina (Huffman et al 1993(Huffman et al , 1996a. In vitro pharmacological assays of V. amygdalina demonstrate a broad range of antiparasitic activities (e.g., Ohigashi et al 1994;Oyeyemi et al 2018).…”

Section: Antiparasitic Propertiesmentioning

confidence: 99%

Medicinal Properties in the Diet of Tibetan Macaques at Mt. Huangshan: A Case for Self-Medication

Huffman

Sun

2019

The Behavioral Ecology of the Tibetan Macaque

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Life history strategies include growth, maintenance, and reproduction (Gadgil and Bossert 1970), all of which are dependent upon a proper diet for metabolic functions. Animal feeding strategies are based on finding and consuming a balance of the most essential nutritional elements, carbohydrates, fats, proteins, trace elements, and vitamins, while at the same time avoiding the negative impacts of secondary metabolites in plants (Lambert 2011; Simpson et al. 2004). These secondary metabolites protect plants from predation by an array of insect and vertebrate herbivores that prey upon them by reducing palatability and digestibility (Freeland and Janzen 1974; Glander 1982; Rosenthal and Berenbaum 1992). Nonetheless, this does not always inhibit animals from ingesting such plants in tolerable amounts for purposes other than nutrition. The idea that animals may ingest plants for their medicinal value was first suggested by Janzen (1978), based on a variety of anecdotal reports from the wild. The study of primate self-medication then began in earnest as a scientific discipline in the mid-to-late 1980s with observations of chimpanzees in the wild (see Huffman 2015). Nonetheless, it is widely documented that humans have traditionally seen animals as a source of knowledge about the use of plants for their medicinal value

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Section: Antiparasitic Propertiesmentioning

confidence: 99%

Medicinal Properties in the Diet of Tibetan Macaques at Mt. Huangshan: A Case for Self-Medication

Huffman

Sun

2019

The Behavioral Ecology of the Tibetan Macaque

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“…Among compounds isolated from V.A, three main groups are notable for their bioactivity and potential therapeutic uses: sesquiterpene lactones (vernolide, vernodalol), flavonoids (luteolin and its glucoside conjugates), and saponins (vernoamyosides) (Oyeyemi, Akinlabi et al 2018). The quantity of individual compounds in the foam would depend on their intrinsic hydrophobicity and aqueous solubility, which are dictated by their chemical topology.…”

Section: Structural Properties Of the Main Bioactive Compounds In Thementioning

confidence: 99%

“…Due to these reasons, bubble separation and condensation could be considered effective for the targeted compounds of V. amygdalina extract. The phytochemical profile of V. amygdalina is also beneficial for this method as the targeted compounds in this plant are hydrophobic in nature (Oyeyemi, Akinlabi et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Improving the quality of Vernonia amygdalina extract by ultrasound‐assisted extraction coupled with gas bubble flotation

Luu¹,

Le²,

Le³

et al. 2019

J Food Process Engineering

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V. amygdalina (V.A) is an herb commonly used in folk medicine; it possesses various compounds with therapeutic capabilities. Traditional extraction approaches applied to this plant may destroy its bioactive compounds and inherently contaminate them with toxic organic solvents. In this study, ultrasound-assisted extraction combined with gas-bubble flotation was applied to increase V.A extraction yield. The efficiency of water maceration was increased by 200%, without the drawbacks of the conventional extraction methods. The total phenolic content yield was 189 ± 12.7 (mg GAE/g dry weight) with a condensation efficiency of 115 ± 5.7%; and the total flavonoid content was 6.44 ± 1.68 (mg QE/g dry weight). Additionally, the antioxidant activity of the condensed foam was enhanced up to 120%. Analysis of the extract by FTIR revealed the presence of extractable chemical families: sesquiterpene lactones, saponins and flavonoids, and that the chemical characteristics of the extract were also preserved This article is protected by copyright. All rights reserved. This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as

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“…The flower petals are white except on the largest lobe, which is purple. The flowers are small, blue or violet, 3-12 cm in diameter (Bello et al, 2018;Oyeyemi et al, 2018). The fruits are oblong, about 3 cm long.…”

Section: Introductionmentioning

confidence: 99%

“…The fruits are oblong, about 3 cm long. They are green when young and purplish black when ripe (Oyeyemi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Toxicological Effects of Aqueous Leaf Extract of Dinya (Vitex Dodianna) on Liver Enzymes of Albino Rats

2020

Central European Journal of Botany

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The research was piloted to establish the hepatotoxic potentials of the leaf extract of Vitex dodiana on liver enzymes of apparently healthy albino rats. A total of sixteen (16) albino rats were clustered into four (4) groups of four (4) rats each designated as group AD , Group A served as control while groups B, C and D were treated with 200 mg/kg, 300 mg/kg, and 400 mg/kg aqueous leaves of extract of Vitex dodiana respectively for a period of two weeks. The liver enzymes were determined using spectrophotometric methods. The activity of AST was slightly decreased to 6.5±0.20 in the rats treated with 200 mg/kg body weight of the extract and slightly decreased to 5.2±0.12 and 5.0±0.33 in the rats treated with 300 and 400 mg/kg body weight of the extracts respectively when compared with untreated group (5.6±0.15) with no significant (P > 0.05) differences. The activity of ALT was slightly decreased to 2.5±0.11 in the rats treated with 300mg/kg body weight of the extracts and slightly increased to 2.64±0.17 and decreased to 2.4±0.04 in the rats treated with 200 and 400 mg/kg body weight of the extracts respectively when compared with untreated group (2.8±0.31) with no significant (P > 0.05) difference. The result of ALP also showed no significant (P < 0.05) difference of serum ALP activity, though it was observed in the rats treated with 400 mg/kg body weight of the extracts the serum concentration decreased to 100.06±0.66, and 102.44±2.34 at 300 mg/kg body weight and 104.56±1.20 at 200 mg/kg body weight of the extracts, but no significant (P > 0.05) difference was observed when compared with untreated group (106.26±8.51). The results revealed no significant (P < 0.05) decrease in the activity of serum liver enzymes of the rats treated with the three different doses of Vitex dodiana extract when compared with control rats. In conclusion, acute oral administration of aqeous extract of Vitex dodiana was found to be relatively safe.

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Vernonia amygdalina : A folkloric herb with anthelminthic properties

Cited by 65 publications

References 82 publications

Medicinal Properties in the Diet of Tibetan Macaques at Mt. Huangshan: A Case for Self-Medication

Medicinal Properties in the Diet of Tibetan Macaques at Mt. Huangshan: A Case for Self-Medication

Improving the quality of Vernonia amygdalina extract by ultrasound‐assisted extraction coupled with gas bubble flotation

Toxicological Effects of Aqueous Leaf Extract of Dinya (Vitex Dodianna) on Liver Enzymes of Albino Rats

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