Vernonia patula (Dryand.) Merr. and Leucas chinensis (Retz.) R. Brown exert anti-inflammatory activities and relieve oxidative stress via Nrf2 activation

Wu, Pei-Shan; Jeng, Jingyueh; Yang, Jeng-Fu; Kao, Vivia Yu-Ying; Yen, Jui-Hung; Wu, Ming-Jiuan

doi:10.1016/j.jep.2020.113155

Cited by 8 publications

(6 citation statements)

References 60 publications

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“…In vitro and in vivo investigations have shown few ethnopharmaceutical activities, including antioxidative, anti-inflammatory, and anti-neoplastic effects. 23,25,51 –53 Therefore, the present study revealed, for the first time, the beneficial health effects of LUT against DOX-induced oxido-inflammatory responses in the reproductive organs of male Wistar albino rats. Rats exposed to DOX exhibited marked (p < 0.05) diminutions in the mean body weight, thus indicating general toxicity and alterations of metabolic functions.…”

Section: Discussionsupporting

confidence: 55%

“…Again, the reduction in the relative testis and epididymis weights following DOX treatment could be due to the degeneration of the structural morphology of the seminiferous tubules and loss of germline cells in rats. 56 Conversely, the administration of LUT abrogated the observed alterations in mean body weight and relative testis and epididymis weights of the rats, and this could be due to the direct effect of Luteolin on genes controlling IL-6 gene, 52 growth hormones well as germ cells.…”

Section: Discussionmentioning

confidence: 91%

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Luteolin abates reproductive toxicity mediated by the oxido-inflammatory response in Doxorubicin-treated rats

Owumi

Ijadele

Arunsi

et al. 2020

Toxicology Research and Application

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The anti-neoplastic use of Doxorubicin (DOX) is hampered by several limitations, including reproductive toxicity. Luteolin (LUT)–a phytochemical-biological benefits include antioxidative and anti-inflammatory actions. Here we examined the protective effect of LUT against DOX-induced reproductive toxicity in an in vivo model—male albino Wistar rats—randomly assigned to five groups and treated as follows: Control (corn oil 2 mL/kg; per os), LUT (100 mg/kg; per os), DOX (2 mg/kg) by intraperitoneal injections, co-treated groups received LUT (50 and 100 mg/kg) with DOX. Treatment with DOX alone, significantly (p > 0.05), reduced biomarkers of testicular function, reproductive hormone levels, testicular and epididymal antioxidant, and anti-inflammatory cytokine. DOX increased (p > 0.05) sperm morphological abnormalities, as well as reactive oxygen and nitrogen species, lipid peroxidation, xanthine oxidase, a pro-inflammatory cytokine, and apoptotic biomarkers. Furthermore, testicular and epididymal histological lesion complemented the observed biochemical changes in treated rats. LUT co-treatment resulted in a dosage-dependent improvement in rats’ survivability, antioxidants capacity, reduction in biomarkers of oxidative stress, pro-inflammatory cytokines, and apoptosis in rat’s testis and epididymis. Also, LUT treatment resulted in improved histological features in the testis and epididymis, relative to DOX alone treated rats. LUT co-treatment abated DOX-mediated reproductive organ injuries associated with pro-oxidative, inflammatory, and apoptotic mechanisms. LUT supplementation may serve as a phyto-protective agent in alleviating male reproductive organ toxic injuries associated with Doxorubicin therapy.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 91%

Luteolin abates reproductive toxicity mediated by the oxido-inflammatory response in Doxorubicin-treated rats

Owumi

Ijadele

Arunsi

et al. 2020

Toxicology Research and Application

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“…Vernoniapatula, with good anti‐inflammatory properties, could inhibit the NO and IL‐6 production and the expression of iNOS, IL‐6, IL‐1 β, and CCL2 genes. Chryseriol and luteolin were significantly related to their anti‐inflammatory effects and also had important effects on anti‐AD (Wu et al, 2020). Luteolin had neuroprotective properties against cognitive deficits in chronic cerebral hypoperfusion rats and mice on a high‐fat diet (Fu et al, 2014; Liu et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Role of corn silk for the treatment of Alzheimer's disease: A mechanism research based on network pharmacology combined with molecular docking and experimental validation

2023

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This study aimed to research the possible mechanism and effect of active ingredients of corn silk on Alzheimer's disease (AD) by the method of network pharmacology, molecular docking, and animal experiments. The active ingredients of Corn silk were obtained by searching the TCMSP database and the targets corresponding to the active ingredients of Corn silk were obtained through the TCMSP and SwissTargetPrediction platforms, and the AD targets were obtained in the GeneCards, OMIM, and DisgeNET databases. Cytoscape was employed for creating the “active ingredient‐target” relationship network; STRING and Cytoscape for creating the protein–protein interaction (PPI) network. Besides, Meta scape was used for Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the intersecting targets; AutoDockTools and Pymol for molecular docking and visualization of core ingredients and core targets; and animal experiments for verifying the anti‐AD effect of luteolin. A total of 12 active ingredients of corn silk were screened, including 465 targets and 209 intersected targets. Moreover, GO functional analysis results showed that the anti‐AD effect of corn silk was mainly reflected in phosphotransferase activity, response to hormone, membrane raft, etc.; KEGG results indicated the main pathways involving cancer, Alzheimer disease, etc.; and the molecular docking results revealed excellent binding of the core ingredients (α‐tocopheryl quinone, luteolin, etc.) to the core targets. Besides, the outcomes of animal experiments exhibited that luteolin not only reduced the expression of inflammatory factors TNF‐α and IL‐1β in mice but also attenuated inflammation. With the help of network pharmacology and experimental validation, the material basis and mechanism of the anti‐AD of corn silk have been explored in this study. Briefly speaking, luteolin from corn silk plays an anti‐AD role by inhibiting inflammation.

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“…Among species of Vernonia, antitumor properties have been described Vernonia amygdalina [5,11,47,48,49], Vernonia bockiana [50], Vernonia cinerea [51,52,53], Vernonia condensate [54], Vernonia divaricata [43], Vernonia extensa [44], Vernonia fimbrillifera [55], Vernonia glaberrima [56,57], Vernonia kotschyana [58], Vernonia leopoldii [59], Vernonia mespilifolia [60], Vernonia pachyclada [61], Vernonia paniculata [62], Vernonia patula [63], Vernonia polyanthes [64], and Vernonia scorpioides [65,66,67], Vernonia zeylanica [42,68].…”

Section: Genus Antitumor Activitymentioning

confidence: 99%

Genus Vernonia (Asteraceae): A Promising Source of Antitumor Agents with Pharmacological Potentials

Gonzatto

Araújo²,

Albuquerque³

2022

AIR

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Antitumor research leads to the development of new molecules that act specifically in tumor cells by blocking or inhibiting their molecular targets. New therapeutic approaches for the screening of bioactive compounds present in medicinal plants have received increasing attention due to their chemopreventive and chemotherapeutic properties. In ethnomedicine, plants of the genus Vernonia (Asteraceae) are widely used and some have shown several and interesting biological activities, including anticancer. This present study aimed to document experimental evidence supporting the claimed ethnomedical uses of Vernonia species for the treatment of various types of cancer and also to confirm the anticancer potential of these plants. The compounds isolated from aqueous and alcoholic extracts, as well as fractions from different parts of Vernonia plants have acted as potential anticancer agents that inhibited the proliferation of various types of human cancer cell lines, including cervical cancer cells, melanoma cells, promyelocytic leucemia cells, breast adenocarcinoma cells, ovarian cancer, liver cancer cell, and human lung cancer cells. Studies have correlated the antitumor activity of Vernonia plants by inducing apoptosis and modulating mitochondrial signaling pathways controlled by NF-κB, Bcl-2 and p53, as well as inducing DNA damage and arresting the cell cycle at the S-phase checkpoint by oxidative stress. In conclusion, Vernonia species act as a promising source for drug development. However, further studies are needed to explore the exact mechanism of action, pharmacokinetics, chronic toxicological studies, safe dose consumption, and possible interactions with other herbs.

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Vernonia patula (Dryand.) Merr. and Leucas chinensis (Retz.) R. Brown exert anti-inflammatory activities and relieve oxidative stress via Nrf2 activation

Cited by 8 publications

References 60 publications

Luteolin abates reproductive toxicity mediated by the oxido-inflammatory response in Doxorubicin-treated rats

Luteolin abates reproductive toxicity mediated by the oxido-inflammatory response in Doxorubicin-treated rats

Role of corn silk for the treatment of Alzheimer's disease: A mechanism research based on network pharmacology combined with molecular docking and experimental validation

Genus Vernonia (Asteraceae): A Promising Source of Antitumor Agents with Pharmacological Potentials

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