Verruciform xanthoma of the palatal gingiva: a report of two cases

Ryu, Dong Jin; Lee, Sang Hoon; Yuk, Jong In; Kim, Hyung Jun; Huh, Joing-Ki; Park, Kwang-Ho

doi:10.5125/jkaoms.2013.39.6.292

Cited by 7 publications

(14 citation statements)

References 12 publications

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“…OVX has good prognosis. Only 6 cases with recurrence after surgical excision (12%) (mean time of recurrence 2.8±1.5 years) were recorded ( 17 , 22 , 33 , 7 , 47 , 57 ). This underlines the necessity for a follow-up.…”

Section: Discussionmentioning

confidence: 99%

Oral verruciform xanthoma: Report of 13 new cases and review of the literature

Tamiolakis

Theofilou²,

Tosios³

et al. 2018

Med Oral

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BackgroundOral verruciform xanthoma (OVX) is a rare lesion. The purpose of the present study is to describe the clinical features of 13 OVXs and review all cases reported in the English literature.Material and MethodsThirteen cases of OVX diagnosed during a 47-year period were retrospectively collected. The patients’ gender and age, as well as the main clinical features of the lesions were retrieved from the biopsy request forms. Pubmed®, Scopus® and Google ScholarTM electronic databases were searched with the key word “verruciform xanthoma”. Only cases of histologically confirmed OVX were included in the study.ResultsThe 13 OVXs represented approximately 0.04% of 35,617 biopsies accessioned during the study period. They affected 13 patients, 8 males and 5 females with a mean age of 48.8±14 years. They mainly appeared as asymptomatic granular nodules or plaques, with elastic or normal consistency and white color, in the gingiva or hard palate. Literature review yielded 416 cases of OVX. With the addition of cases of the present study, 429 cases of OVX have been presented in the English literature. OVX has a slight male predominance with a male to female ratio of 1.4:1 and the majority of patients are in the 5th to 7th decade of life. Clinically, OVX mainly presents as an asymptomatic, single, papillary or granular plaque or nodule, with elastic or soft consistency and white, red or pink color. It measures approximately 1cm and is most commonly located on the gingiva, tongue, hard palate or buccal mucosa. The treatment of choice is surgical excision with little rates of recurrence.ConclusionsVerruciform xanthoma is a rare lesion most often encountered on the ginigival mucosa. As its clinical presentation is not pathognomonic, it should be included in the differential diagnosis of verrucous or papillary lesions. Key words:Oral verruciform xanthoma, oral tumors.

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Section: Discussionmentioning

confidence: 99%

Oral verruciform xanthoma: Report of 13 new cases and review of the literature

Tamiolakis

Theofilou²,

Tosios³

et al. 2018

Med Oral

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“…We found 12 studies in the literature reporting verruciform xanthoma in the hard palate6812131415161718192021. Articles without clinical information, immunohistochemical studies, multiple lesions, or involving the soft palate were excluded.…”

Section: Discussionmentioning

confidence: 99%

Verruciform xanthoma in the hard palate: a case report and literature review

Garcia

Pagin

Santos

et al. 2016

J Korean Assoc Oral Maxillofac Surg

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Oral verruciform xanthoma (OVX) is an uncommon lesion that appears on the oral mucosa. The aim of this paper was to discuss the probable etiopathogenesis of OVX in the hard palate, reinforcing the importance of including this lesion in the differential diagnosis of verrucous lesions. A 43-year-old male smoker presented with a painless lesion with a verrucous surface and erythematous spots on the hard palate. Excisional biopsy revealed oral mucosa consisting of hyperkeratosis, acanthosis, and elongated rete pegs. Subjacent connective tissue showed numerous foam cells with clear cytoplasm and pyknotic nucleus, negative on periodic acid-Schiff staining. Immunohistochemical analysis revealed foam cells positive for anti-CD68 antibody, while anti-KI-67 antibody was restricted to the basal layer of the oral epithelium. A final diagnosis of OVX was established. The patient showed no signs of recurrence after seven months of follow-up. Physical trauma and smoking habits can be directly related to the etiology of verruciform xanthoma because the lesion is chronic and inflammatory with slow growth, and sites if high trauma are more often affected by such a lesion. The hard palate is the second most commonly affected site, and local trauma caused by smoking can be a cause of this type of lesion.

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“…[ 1 ] The lesions are usually slow growing, painless, pedunculated, or sessile. [ 2 ] Shafer in 1971 presented 15 cases of xanthoma and was the first to coin the term verruciform xanthoma. [ 3 4 ] Verruciform xanthoma can occur as a result of irritation to the oral mucosa or unknown immune reaction.…”

Section: Introductionmentioning

confidence: 99%

Verruciform xanthoma of the tongue

Byakodi

Kumar

Patil

et al. 2017

Natl J Maxillofac Surg

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Verruciform xanthoma is a benign, soft tissue lesion occurring on the orogenital mucosa. Presentation of oral lesions can be pink, yellow, or gray raised plaque or papule with granular, papillary, or verrucous in nature. There are many theories proposed for the etiopathogenesis of verruciform xanthoma. Clinical observations may be misguiding as the lesion resembles malignant and premalignant lesions. Histopathological confirmation is essential for diagnosis and avoiding radical surgery. Once excised, the lesion does not recur. Here, we present a case report of verruciform xanthoma of the tongue in a 50-year-old female patient.

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Verruciform xanthoma of the palatal gingiva: a report of two cases

Cited by 7 publications

References 12 publications

Oral verruciform xanthoma: Report of 13 new cases and review of the literature

Oral verruciform xanthoma: Report of 13 new cases and review of the literature

Verruciform xanthoma in the hard palate: a case report and literature review

Verruciform xanthoma of the tongue

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