Verrucous Carcinoma of Skin

Abstract

Five different cases of verrucous proliferative lesions of skin are described and discussed. One of each developed in a chronic ulcer on a heel, in a scar on a lower leg, and on the penis, and two appeared in the region of the buttock in relation to chronic inflammatory sinuses. All these lesions showed morphological and clinical features of verrucous carcinoma which are described. It has been concluded that the variously named verrucous lesions in the literature (epithelioma cuniculatum, florid papillomatosis, giant cutaneous papilloma and papillomatosis cutis carcinoides), as well as our five cases represent a verrucous carcinoma which is a particular type of squamous cell carcinoma. This tumor develops typically in moist areas which are frequently sites of chronic inflammation. Despite the favorable prognosis, it is a potentially invasive tumor.

Carcinoma cuniculatum de la cavité buccale : revue de la littérature

“…Cette évolution métastatique, exceptionnelle, est à comparer à celle du carcinome épidermoïde bien différencié [4] . Kraus et PerezMesa [28] , dans leur série de 105 cas, ne rapportent aucune métastase, exception faite des cas de transformation anaplasique après radiothéra- pie. Owen et coll.…”

“…En revanche, pour le carcinome verruqueux de la cavité buccale, il est maintenant admis qu'une telle évolution est possible après irradiation et plusieurs cas, avec dissémination ganglionnaire, ont été rapportés [13,18,38,41] ; le pronostic devient alors souvent dramatique avec extension locale rapide et métastases à distance. Sur 17 cas de carcinome verruqueux irradié, Kraus et Perez-Mesa [28] ont observé 4 cas de transformation anaplasique : ils ont tous eu une issue fatale en moins d'un an (3 concernaient la cavité buccale, et un les fosses nasales). Le mécanisme exact de cette évolution reste mal expliqué.…”

Keratoacanthoma centrifugum marginatum versus Low-Grade Squamous Cell Carcinoma

“…Clinically, the KCM here re ported differs from verrucous carcinoma, though the histologic distinction, if wide sec tions are not examined [6], is at times diffi cult. The verrucous carcinoma shows a pa pillomatous proliferation with narrow crypts filled by squamous debris.…”

Fatal Genital Verrucous Carcinoma

“…Histopathologically, it shows minimal (if any) atypia, and biologically it is typified by a low incidence of metastasis. [1][2][3][4][5] There are four well-recognized clinicopathological types 1 of verrucous carcinoma. They include giant condyloma acuminatum or Buschke-Loewenstein tumor in the anogenital area, 3 oral florid papillomatosis or Ackerman tumor in the oroaerodigestive area, 2 epithelioma cuniculatum on the feet, 4 and cutaneous verrucous carcinoma or papillomatosis cutis carcinoides on other cutaneous sites.…”