Verrucous carcinoma of the leg positive for human papillomavirus DNA 11 and 18: A case report

Garven, Tom C.; Thelmo, William; Victor, Jacob M.; Pertschuk, Louis P.

doi:10.1016/0046-8177(91)90272-q

Cited by 45 publications

(22 citation statements)

References 24 publications

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“…Indeed verrucous carcinoma often develops in areas of actinic damage, scars from burns, previous radia tion and solar keratoses. Recently some authors have also postulated that human papillomavirus may be implicated in the pathogenesis of this tumor [20][21][22][23][24][25]. The results of our study indicate that p53 protein overexpression in compari son to normal epidermis is found in 62.5-75% of verru cous carcinoma by using two different monoclonal antibod ies, suggesting hat this protein could be incriminated in the pathogenesis of this controversial entity.…”

Section: Discussionsupporting

confidence: 53%

p53 Protein Overexpression in Verrucous Carcinoma of the Skin

Noël¹,

Peny²,

Dobbeleer

et al. 1996

Dermatology

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Background: Verrucous carcinoma is a rare variant of well-differentiated squamous cell carcinoma which is characterized by a marked local aggressivity and a poor metastatic potential. Until now, little has been known about the oncogenic mechanisms of this tumor. Recently, extensive investigations have shown that p53 protein, a nuclear protein with oncogene-suppressing activity, may play a crucial role in cell transformation and immunoreactivity for this protein is found in a wide variety of cancers. Objective and Method: The aim of the present study is to examine the frequency of immunohistochemically detectable p53 protein by using two monoclonal antibodies (D07 and BP53-12) in 8 cases of formalin-fixed and paraffin-embedded specimens of verrucous skin carcinoma. Results: Overexpression of p53 protein was detected in 6 (75%) of the cases examined with the D07 antibody and in 5 (62.5%) cases with BP53-12. The p53 positivity was shown in a peripheral distribution affecting mainly the basal cell layers of tumoral islands. Conclusion: In a high percentage of verrucous carcinoma, p53 immunoreactivity has not been previously described in the literature and our findings suggest that abnormal expression of p53 tumor suppressor protein is a common event in the pathogenesis of this tumor.

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Section: Discussionsupporting

confidence: 53%

p53 Protein Overexpression in Verrucous Carcinoma of the Skin

Noël¹,

Peny²,

Dobbeleer

et al. 1996

Dermatology

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“…However, more than 70 HPV types have been described and we can not exclude that other types than those that we tested might infect cutaneous lesions from transplant recipients. The detection of mucosal HPV types 6, 11, 16 and 18 which was previously described in few cases of skin lesions from the general population [2,15,28], was a common feature in our grafted patients [37]. HPV type 5, commonly found in skin cancers from patients with epidermodysplasia verruciformis [43], has also been previously found in grafted patient skin lesions [3,36,42].…”

Section: Discussionsupporting

confidence: 76%

Immunohistochemical detection of p53 protein in cutaneous lesions from transplant recipients harbouring human papillomavirus DNA

P�lisson

Chardonnet

Euvrard

et al. 1994

Vichows Archiv A Pathol Anat

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Human papillomaviruses (HPV) are thought to be involved in the malignant evolution of cutaneous lesions from transplant recipients. As E6 proteins from potentially oncogenic HPV types degrade p53 tumour suppressor gene product in vitro, we analysed p53 protein status in benign, premalignant and malignant skin lesions from grafted patients, to determine whether HPV may interfere with p53 function. With immunohistochemistry, p53 protein accumulation was detected in 70% of skin lesions from grafted patients, p53 immunoreactivity was confined to basal keratinocytes in benign lesions (warts, condylomas), while suprabasal keratinocytes were also stained in premalignant and malignant skin lesions (precancerous keratoses, squamous cell carcinomas). Multiple HPV carriage was detected with in situ hybridization in benign and malignant skin lesions from transplant recipients: low risk HPV types 1, 2, 6, 11 and potentially oncogenic HPV types 5, 16, 18 were frequently found. There was no clear correlation between p53 detection and the presence of the HPV types under study. The frequent detection of p53 protein in cutaneous lesions from grafted patients is suggestive of p53 protein accumulation interfering with normal function. Our results may reflect the presence of mutated p53 proteins due to the mutagenic effect of ultra-violet (UV), or wildtype p53 protein accumulation in response to UV-induced DNA damage, or may be produced by the interaction with HPV-encoded E6 proteins.

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“…VC has histological similarities to plantar warts and HPV may be the causative agent. 3,4 It typically occurs in men in their 4 th to 6 th decade of life. It follows a chronic course evolving from a small skin lesion to a large fungating deeply penetrating mass.…”

Section: Discussionmentioning

confidence: 99%