Verrucous carcinoma of the oral cavity

McDonald, John S.; Crissman, John D.; Gluckman, Jack L.

doi:10.1002/hed.2890050106

Cited by 62 publications

(26 citation statements)

References 26 publications

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“…Another study involving 30 cases of laryngeal VC also showed that surgery is the optimal therapy but that radiation and even chemotherapy can be used as alternatives for inoperable cases [20]. Although the older literature raised the issue of radiotherapy-related anaplastic or malignant transformation in VC [3,9,[21][22][23][24][25], this has clearly been refuted. Radiotherapy is now an accepted treatment modality for inoperable VC or for patients who are poor surgical candidates [26,27].…”

Section: Discussionmentioning

confidence: 99%

Verrucous Carcinoma with Dysplasia or Minimal Invasion: A Variant of Verrucous Carcinoma with Extremely Favorable Prognosis

Patel

Chernock

Sinha

et al. 2014

Head and Neck Pathol

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Verrucous carcinomas (VC) recur locally but do not metastasize in the absence of an invasive squamous cell carcinoma (SCC) component. Although excluded from the definition of pure VC, some tumors harbor only dysplasia or minimal invasion, findings of unknown clinical significance. Surgically resected VC cases from two institutions were collected and categorized into three types: VC, VC with dysplasia or minimal invasion (VCDMI), defined as SCC less than or equal to 2 mm in depth, and SCC arising in VC (SCC-VC) where the SCC was greater than 2 mm in depth. Cases were also matched with conventional SCC based on location and T and N-stages, and clinical follow up was obtained. Of the 58 total cases, 18 were VC, 26 VCDMI, and 14 SCC-VC. Only 1 of 18 (5.6 %) VC and 5 of 26 (19.2 %) VCDMI cases recurred locally (p = 0.37) versus 7 of 14 (50 %) SCC-VC (p = 0.01). All VC and VCDMI cases were node negative at presentation whereas SCC-VC had nodal metastases in 2 of 14 (14.3 %) cases. No patients with VC or VCDMI died from disease, whereas 5 of 14 (35.7 %) patients with SCC-VC died from disease. T-stage matched conventional SCC cases from institutional databases had worse outcomes than VC and VCDMI, but not after they were matched for both T and N-stages. Our findings suggest that dysplasia and/or minimal invasive SCC do not adversely affect outcomes in tumors otherwise showing diagnostic features of VC.

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Section: Discussionmentioning

confidence: 99%

Verrucous Carcinoma with Dysplasia or Minimal Invasion: A Variant of Verrucous Carcinoma with Extremely Favorable Prognosis

Patel

Chernock

Sinha

et al. 2014

Head and Neck Pathol

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“…Verrucous carcinoma is a rare variant of squamous cell carcinoma that presents in the head and neck with the most common sites being the oral cavity and larynx [1][2][3][4][5][6][7][8]. It is so uncommon, in fact, that verrucous carcinoma composes only 5% of tumors at these sites [2,14].…”

Section: Introductionmentioning

confidence: 99%

Temporal Bone Verrucous Carcinoma: Outcomes and Treatment Controversy

Miller¹,

Martin

Juillard³

et al. 2010

The Laryngoscope

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Verrucous carcinoma is a rare tumor that presents in the head and neck with the most common sites being the oral cavity and larynx. Fourteen cases of verrucous carcinoma of the temporal bone have been described in literature; this study aims to examine treatment outcomes and discuss the controversy surrounding postoperative radiation. The study design included a literature review along with individual case report in the setting of a tertiary care medical center. Outcome analysis of all cases of verrucous carcinoma of the temporal bone, which are documented in the English literature, and presentation of a single patient report including gross, histologic and radiologic analyses were performed. The longest recorded survival for verrucous carcinoma of the temporal bone occurs in patients treated with surgery alone. Poorer outcomes for patients treated with adjuvant (chemo)radiation may be due to more advanced stage of disease at the time of treatment. Early reports of radiation leading to tumor dedifferentiation or early recurrence are not supported by more recent studies. Whether adjuvant radiation therapy is indicated in verrucous carcinoma of the temporal bone remains controversial.

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“…Some oral verrucous carcinomas may be associated with small outbreaks of EC (16,25,26) or regional lymphatic metastases (27,28). In one study (26), it was observed that 21 out of 104 oral verrucous carcinomas had poorly differentiated EC outbreaks.…”

Section: Investigationsmentioning

confidence: 99%

Verrucous Carcinoma Ackerman — Oral Florid Papillomatosis. Case Presentation

2018

RoJCED

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Verrucous carcinoma of the oral cavity

Cited by 62 publications

References 26 publications

Verrucous Carcinoma with Dysplasia or Minimal Invasion: A Variant of Verrucous Carcinoma with Extremely Favorable Prognosis

Verrucous Carcinoma with Dysplasia or Minimal Invasion: A Variant of Verrucous Carcinoma with Extremely Favorable Prognosis

Temporal Bone Verrucous Carcinoma: Outcomes and Treatment Controversy

Verrucous Carcinoma Ackerman — Oral Florid Papillomatosis. Case Presentation

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