Verrucous growth on leg

Mohanty, L; Mohanty, Pooja; Padhi, T; Samantray, Suman

doi:10.4103/0378-6323.27770

Cited by 6 publications

(5 citation statements)

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“…Bullosis diabeticorum is a rare condition moslty affecting patients with a long history of DM but the existing estimates remain poorly understood [35]. A previous Indian study estimated its prevalence at 1% [36], and another study at 0.5% in the USA [37]. Our study finds a prevalence that confirms the data of the literature and the rarity of this pathology.…”

Section: Specific Dermatological Manifestations and Diabetes Mellitussupporting

confidence: 85%

Diabetes-associated dermatological manifestations in primary care and their association with vascular complications

Trihan

Lanéelle

Metcalfe³

et al. 2020

J Diabetes Metab Disord

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Introduction Although type 2 diabetes mellitus (DM) is a global public health problem, the diabetes-associated dermatological (non-infectious) manifestations (DADM) remain poorly understood and under-diagnosed. We aimed to evaluate the prevalence of 7 known DADM in a primary care setting, and their association macro/microvascular complications. Methods Cross-sectionnal study included patients consulting in general practice for DM-follow up, from November 2016 to January 2017. Patients aged <18 years old or consulting for other reason than DM follow up were excluded. Each patient were screened for diabetic dermopathy (DD), Huntley's papules (HP), necrobiosis lipoidica diabeticorum (NL), acanthosis nigricans (AN), cheiroarthropathy (CA, or stiff hand syndrom), scleredema adultorum of Buschke (SB) and bullosis diabeticorum (BD). Results 213 diabetic patients were included over a period of 3 months. We found a prevalence of 17.8% (38 patients) for DD, 8.5% (18) for HP, 2.8% (6) for NL, 2.3% (5) for AN, 1.9% (4) for CA, 1.4% (3) for SB and 1.4% (3) for BD. DADM seems to be a risk factor for vascular complications (OR 1.97, p ≤ 0.001). Association with vascular involvement was stronger with DD and macroangiopathy (OR 1.86, p ≤ 0.001), and with NL and microangiopathy (OR 9.7, p ≤ 0.001). Conclusion In primary care, DM-associated dermatological manifestations present similar prevalence rates to a tertiary care setting, based on litterature. Complete dermatological examination of diabetic patients is essential and could lead to a better overall management of the pathology, as diabetic cutaneous manifestations appear as a sign of vascular involvement.

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Section: Specific Dermatological Manifestations and Diabetes Mellitussupporting

confidence: 85%

Diabetes-associated dermatological manifestations in primary care and their association with vascular complications

Trihan

Lanéelle

Metcalfe³

et al. 2020

J Diabetes Metab Disord

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“…Similarly, multiple cutaneous malignancies were reported in an individual with XP in a study by Mohanty P et al 15 This patient developed squamous cell carcinoma of conjunctiva, basal cell carcinoma of nose and malignant melanoma of cheek. 15 The incidence of internal malignancy is said to be 10-20 times higher in patients with XP than in normal individuals. 16 None of these patients had internal malignancy in our study.…”

Section: Figure 1: Focus Of Melanoma (A) and Basal Cell Carcinoma (B)...supporting

confidence: 58%

Myrid of histopathological features of malignancy in Xeroderma pigmentosum

2013

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Background: Xeroderma pigmentosum is a rare autosomal recessively inherited disorder affecting 1 in 2,50,000 population. It shows genetic heterogeneity with at least ten different complementation groups identified which have different clinical presentations. They tend to have a more than 1000 fold increased risk of developing cancers in sun-exposed areas as a result of a DNA repair defect. This study presents a myriad of histopathological features of malignancies seen in individuals with this rare. Materials and Methods: Biopsies received from patients with a clinical diagnosis of Xeroderma Pigemntosa at the department of pathology, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, from April 2008 to June 2012 were included in the study. Hematoxylin and eosin stained sections were examined. Clinical history was retrieved from the computer data base of the department. Results: During the study period, a total of eleven cases of Xeroderma pigmentosum presented with a biopsied lesion. All of these were malignant lesions. No benign lesions were seen. The age range of these patients was 6-30years with a mean of 18.8 years. The male to female ratio was 4.5:1. The most common malignancy seen was squamous cell carcinoma 7/11 (63.6%) followed by basal cell carcinoma 2/11 (27.2%). A single case presented with basal cell carcinoma of face and melanoma of trunk. The frequently observed site of malignancy was skin of the face followed by conjunctiva. Conclusion: In our population, non melanotic skin cancers affecting the face are more common in young individuals with Xeroderma pigmentosum. DOI: http://dx.doi.org/10.3126/jpn.v3i6.8996 Journal of Pathology of Nepal (2013) Vol. 3, 472-475

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“…In India, such cases are being reported from the sub-Himalayan belt and the coastal areas due to hot and humid climate. [11][12][13] This small tiny fungus is causing disease when they are inoculated by contaminated soil/wood particles into tissue. The histopathological findings of cutaneous chromoblastomycosis consist of acanthosis, pseudoepitheliomatous hyperplasia, dermal microabscess, chronic granulomatous inflammation, multinucleated foreign body type of giant cells, "sclerotic body"/"copper penny body."…”

Section: Discussionmentioning

confidence: 99%

Chromoblastomycosis as a mimicker of neoplastic lesion: A case report

Sarkar¹,

Das²,

Sinhababu³

2017

Int J Med Sci Public Health

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Chromoblastomycosis, a rare fungal infection, occurs most commonly in tropical and subtropical countries. Persons involved in agricultural works are most commonly affected. Traumatic injury by contaminated wood particles/ thorn predispose to chromoblastomycosis. We are reporting a case of chromoblastomycosis in a 50-year-old male presenting with a nodular swelling in the right foot for 2 months. It was clinically suspected to be a neoplastic lesion and was subjected to surgical excision and histopathological examination that demonstrated the presence of fungal hyphae, spores, and the typical "sclerotic bodies." Surgical excision is not needed in chromoblastomycosis as it can be treated by antifungals. Chromoblastomycosis needs to be considered in the initial differential diagnosis of verrucous cutaneous lesions of foot, particularly in agricultural workers.

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Verrucous growth on leg

Cited by 6 publications

References 0 publications

Diabetes-associated dermatological manifestations in primary care and their association with vascular complications

Diabetes-associated dermatological manifestations in primary care and their association with vascular complications

Myrid of histopathological features of malignancy in Xeroderma pigmentosum

Chromoblastomycosis as a mimicker of neoplastic lesion: A case report

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