Verrucous oral focal mucinosis

Rambhia, Kinjal Deepak; Khopkar, Uday

doi:10.4103/0378-6323.174384

Cited by 8 publications

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“…Of these, 60 duplicates were eliminated, and the criteria for inclusion and exclusion were applied to 196 references. A total of 36 articles reporting 100 cases of OFM were selected 1‐5,7‐37 . Most papers were single case reports or case series that originated from 13 different countries: Canada (one case), the United States (34 cases), Venezuela (one case), Brazil (18 cases), Italy (three cases), Sweden (one case), Turkey (one case), Iran (one case), Israel (one case), Japan (five cases), South Korea (one case), India (16 cases), and Australia (16 cases).…”

Section: Resultsmentioning

confidence: 99%

“…Since the first description by Tomich et al in 1974, approximately 100 cases of OFM have been reported in the English‐language literature, 1‐5,7‐37 most of them as single case reports or small series. Herein, we report the clinicopathological characteristics of 21 new cases of OFM, the largest series reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

“…The gingiva and palate are the most affected sites 2,8 . Other reported sites include buccal mucosa, 9,10 tongue, 1,7,11 retromolar trigone, 11 and lips 7 …”

Section: Introductionmentioning

confidence: 99%

“…7,8 The gingiva and palate are the most affected sites. 2,8 Other reported sites include buccal mucosa, 9,10 tongue, 1,7,11 retromolar trigone, 11 and lips. 7 Considering the non-specific clinical appearance of OFM that makes its clinical recognition very unlikely, as well as its microscopic similarity with other oral myxoid lesions, accurate diagnosis requires careful morphological evaluation.…”

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confidence: 99%

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Oral focal mucinosis: A multi‐institutional study and literature review

et al. 2020

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Background: Oral focal mucinosis (OFM) is a rare benign condition of unknown etiology, considered the oral counterpart of cutaneous focal mucinosis. We report the clinicopathologic features of 21 cases of OFM in conjunction with a review of the literature. Methods: Clinical data were collected from the records of five oral and maxillofacial pathology services. All cases were evaluated by hematoxylin and eosin staining, histochemistry, and immunohistochemistry (vimentin, S-100, α-SMA, CD34, and mast cell). Results: The series comprised 14 females (66.7%) and seven males (33.3%), with a mean age of 48.2 ± 20.7 years (range: 8-77 years) and a 2:1 female-to-male ratio. Most of the lesions affected the gingiva (n = 6, 28.6%) and presented clinically as asymptomatic sessile or pedunculated nodules with fibrous or hyperplasic appearance. All cases were negative for S-100 protein, CD34, and α-SMA and positive for Alcian blue staining. Conservative surgical excision was the treatment in all cases, and there was only one recurrence. Conclusion: OFM is a rare benign disorder that is often clinically misdiagnosed as reactive lesions or benign proliferative processes. Dermatologists and pathologists should consider OFM in the differential diagnosis of soft tissue lesions in the oral cavity, mainly located in the gingiva. K E Y W O R D S connective tissue diseases, diagnosis, oral focal mucinosis, oral pathology 1 | INTRODUCTION Oral focal mucinosis (OFM) is considered to be the oral counterpart of cutaneous focal mucinosis (CFM) that likely develops due to an overproduction of hyaluronic acid by fibroblasts. 1-3 As a result, a well-demarcated myxomatous tissue positive for Alcian blue (pH 2.5) is observed microscopically; which may mimic other oral myxoid lesions, such as soft-tissue myxoma, fibrous hyperplasia with myxoid degeneration, nerve sheath myxoma (NSM), myxoid neurofibroma, and mucocele. 1

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The gingiva and palate are the most affected sites 2,8 . Other reported sites include buccal mucosa, 9,10 tongue, 1,7,11 retromolar trigone, 11 and lips 7 …”

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Oral focal mucinosis: A multi‐institutional study and literature review

et al. 2020

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“…Therefore, increased and, indeed, an abnormal overproduction of hyaluronic acid by fibroblasts may well be responsible for the development of focal mucinosis (Tomich et al 1974). The classical clinical presentation of the lesion is as an asymptomatic, soft to firm, sessile or pedunculated mass with a smooth surface (Rambhia et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Oral focal mucinosis of gingiva - a rare case report and review of literature

Dabbiru

Naik

Moturi

et al. 2017

IJDR

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Oral focal mucinosis (OFM) is a rare soft-tissue lesion of unknown etiology. Clinically it appears as asymptomatic round lesions and histologically, characterized by focal myxoid degeneration of connective tissue with presence of stellate shaped fibroblasts which were also evident in the present case. This case report stresses on the fact that diagnosis of OFM is almost impossible hence diagnosis should be confirmed by histopathological examination following incisional or excisional biopsy. Through this article we present a rare case of one such lesion on the gingiva and enumerate the most characteristic and myxomatous lesions. Thus though rare, OFM must be considered in the differential diagnosis of soft tissue overgrowths in oral cavity. Here, we describe the clinical and histopathological presentation and subsequent management of OFM in a female patient.

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Oral Cavity: Nonneoplastic and Benign Neoplasia

Brandwein‐Weber

2018

Textbook of Head and Neck Pathology

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Verrucous oral focal mucinosis

Cited by 8 publications

References 0 publications

Oral focal mucinosis: A multi‐institutional study and literature review

Oral focal mucinosis: A multi‐institutional study and literature review

Oral focal mucinosis of gingiva - a rare case report and review of literature

Oral Cavity: Nonneoplastic and Benign Neoplasia

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