Versatile Catalytic Applications of Manganese(II,III) Schiff Base Complexes (Review)

Sarma, Chandana; Chaurasia, Pankaj Kumar; Bharati, Shashi Lata

doi:10.1134/s1070363219030253

Cited by 10 publications

(8 citation statements)

References 92 publications

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“…Milatovic and Gupta defined manganese (Mn) as an essential element to maintain appropriate functions and structures of numerous biochemical and cellular reactions [38]. Sarma et al defined manganese as a transition metal which has affinity to bond with different types of ligands such as porphyrin (natural Schiff base) to form manganese Schiff base complexes [20].…”

Section: Manganesementioning

confidence: 99%

“…Four decades ago, several transition metal coordination compounds possessing certain anticancer active molecules with biological potentials were assessed and screened for their anticancer in vitro and in vivo activities, while others are at different stages of clinical studies [73]. Among all these metal complexes, manganese complexes are significant with the perspective of their applications in biology, pharmaceutical chemistry, and as catalysts in organic syntheses, biological applications, and pharmaceutical chemistry [20]. Nevertheless, during normal biochemical processing, some essential metals, such as manganese, freely involve themselves in the development of various pathological disorders, such as cancer [23,74].…”

Section: Transition Metal Complexes (Coordination Compounds) As Antic...mentioning

confidence: 99%

“…Recently, numerous anticancer studies were dedicated to copper(CuII/III), iron(FeII/III), osmium(OsII/III), ruthenium(RuII/III), vanadium(VIII/IV/V), and manganese(II/III/IV). e studies revealed their bioinorganic complexes to induce reactive oxygen species (ROS) and human cancer cell death [18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

“…Fifthly, according to the table in Sarma et al's study on the biological applications of manganese Schiff base complexes, statistics showed four references for manganese's antimicrobial studies, four references for manganese's antioxidation studies, and only two references for manganese's anticancer (cytotoxic) studies, which indicated limited studies on anticancer studies of manganese complexes [20]. Sixthly, according to Table 1 in Sarma et al's study on the biological applications of manganese(II/III) Schiff base complexes, statistics showed five references for manganese's antimicrobial studies, four references for manganese's antioxidation studies, forty-seven references for manganese's catalytic studies, and only two references for manganese's anticancer (cytotoxic) studies, which indicated another limited study on anticancer studies of manganese complexes [21].…”

Section: Introductionmentioning

confidence: 99%

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Manganese Schiff Base Complexes, Crystallographic Studies, Anticancer Activities, and Molecular Docking

Odularu

2022

Journal of Chemistry

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Choice of ligands is significant to successful synthesis of metal complexes (coordination compounds). This study reports the use of Schiff base as the right ligand to control the poor bioavailability and neurodegenerative toxicity challenges of manganese ion. In line with this study, document analysis was used as the methodological approach to evaluate the significance of Schiff base ligands in easing these manganese’s challenges and aligning the resultant coordination compounds (manganese Schiff base complexes) as therapeutic agents in anticancer studies. Report also involves crystallographic studies where single crystal X-ray crystallography was used as a chemical characterization technique. In addition, molecular docking studies, MOE2008, and AutoDock software were used to reveal the mode of interaction between the Schiff base and the manganese(II) and (III) ions, as well as scrutinizing the biological efficacy of the manganese(II) and manganese(III) Schiff bases coordination compounds as anticancer agents against some anticancer cell lines. Conclusion drawn was that manganese(II) and manganese(III) Schiff bases coordination compounds gave more active and potent activities than the corresponding Schiff bases. As a result, challenges of neurodegenerative toxicity and poor bioavailability of manganese ion were overcome, and the chelation therapy was fulfilled. Results from single crystal X-ray crystallography confirmed the successful synthesis of manganese(II) and manganese(III) Schiff bases coordination compounds and revealed the mechanism of reaction, while the molecular docking buttressed the biological activities of the Schiff base ligand and manganese Schiff base coordination compounds by portraying the structure activity relationship (SAR) between either Schiff base or the manganese Schiff base coordination compounds and the virtual cancer cell line (receptor protein), where hits were obtained for lead optimizations.

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Section: Manganesementioning

confidence: 99%

Section: Transition Metal Complexes (Coordination Compounds) As Antic...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Manganese Schiff Base Complexes, Crystallographic Studies, Anticancer Activities, and Molecular Docking

Odularu

2022

Journal of Chemistry

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“…They operate as catalysts in several organic reactions, including transformations, hydroxylation, and oxidation reactions. [27][28][29] They also have significant applications in the field of biochemistry. [30][31][32] Mn is a biocompatible element where a limited amount of it plays a vital role in the biochemical reactions that occur on a regular basis in the human body.…”

mentioning

confidence: 99%

Self‐assembly of unexpected [Mn(2‐(1‐hydrazonoethyl)pyridine)Cl₂]_n 1D coordination polymer: Synthesis, structural elucidation, and biological studies

Khalil

Soliman

Khalil

et al. 2022

Applied Organom Chemis

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Self-assembly of (((1-(pyridin-2-yl)ethylidene)hydrazono)methyl)phenol ligand (L 1 ) and MnCl 2 proceeded with the hydrolysis of the ligand affording the new [Mn(L 2 )Cl 2 ] n 1D coordination polymer where L 2 is 2-(1-hydrazonoethyl)pyridine. The structure of [Mn(L 2 )Cl 2 ] n was confirmed using FTIR, CHN, and Xray diffraction of single crystal. It crystallized in the triclinic P-1 crystal system with a = 7.0697(9) Å, b = 8.878(1) Å, c = 9.402(2) Å, α = 113.99(2) , β = 95.48(1) , γ = 111.77(1) , and V = 479.13(15) Å 3 . The Mn(II) is octahedrally coordinated with two nitrogen atoms from L 2 and four chloride ions. The chloride anions act as bridging ligand that connect the Mn(II) centers leading to the formation of the 1D polymer. Based on continuous shape (CShM) measure tool, the coordination configuration is closer to the octahedron rather than a trigonal prism. Using Hirshfeld analysis, the Cl … H (29.2%), H … C (13.6%), and C … C (3.7%) contacts are the most important in the molecular packing of [Mn(L 2 )Cl 2 ] n complex. The ligand L 2 has better antibacterial, antifungal, and antioxidant activities than the Mn(II) complex. The [Mn(L 2 )Cl 2 ] n complex has higher cytotoxic effect than L 2 against both lung carcinoma A-549 and lung fibroblast MRC-5 cell lines. The IC 50 and CC 50 values of the Mn(II) complex are 26.09 ± 1.76 and 60.40 ± 3.74 μg ml À1 , respectively, while 121.23 ± 5.91 and 241.13 ± 13.29 μg ml À1 , respectively, for L 2 . K E Y W O R D Santi-cancer agent, hydrazone, Mn(II) complex, Schiff bases, self-assembly | INTRODUCTIONSchiff bases are compounds generated from the reaction of aldehydes or ketones with compounds carrying amino group. These compounds are being significantly consumed as ligands for the production of numerous types of metal complexes. [1][2][3] Schiff bases and their complexes are known to have interesting catalytic and biological activities. The activity is influenced by complexation of the Schiff base ligand with metals, which can result in the synthesis of new different compounds with several applications in the chemical industry, for both organic synthesis and the pharmaceutical industry. [4][5][6][7][8] Recently, significant attention has been given to arylhydrazone Schiff base ligands since they contain a range of donor atoms that give them a unique potential to bind

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Visible Light‐Driven Photocatalytic Transformation of Thiols to Disulfides in Water Catalyzed by Bi₂S₃

Yang

Wang

et al. 2023

Adv Energy and Sustain Res

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Selective coupling of thiols to produce disulfides is one very important and classic type of coupling reactions. Herein, an environmentally friendly and practical photocatalytic system for oxidative coupling of thiols to disulfides is developed. With no sacrificial agent, no additional additive, just sole water as solvent, performed in air at room temperature, excellent conversions of thiols and excellent selectivities of disulfides are obtained using a cheap and simple semiconductor material of bismuth sulfide (Bi2S3) under blue LED illumination. Excellent conversions and selectivities for coupling of thiols to produce disulfides are obtained, and the system is reusable. The as‐prepared photocatalyst is adequately characterized and the mechanism of photocatalytic reaction is discussed deeply.

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Versatile Catalytic Applications of Manganese(II,III) Schiff Base Complexes (Review)

Cited by 10 publications

References 92 publications

Manganese Schiff Base Complexes, Crystallographic Studies, Anticancer Activities, and Molecular Docking

Manganese Schiff Base Complexes, Crystallographic Studies, Anticancer Activities, and Molecular Docking

Self‐assembly of unexpected [Mn(2‐(1‐hydrazonoethyl)pyridine)Cl₂]_n 1D coordination polymer: Synthesis, structural elucidation, and biological studies

Visible Light‐Driven Photocatalytic Transformation of Thiols to Disulfides in Water Catalyzed by Bi₂S₃

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Versatile Catalytic Applications of Manganese(II,III) Schiff Base Complexes (Review)

Cited by 10 publications

References 92 publications

Manganese Schiff Base Complexes, Crystallographic Studies, Anticancer Activities, and Molecular Docking

Manganese Schiff Base Complexes, Crystallographic Studies, Anticancer Activities, and Molecular Docking

Self‐assembly of unexpected [Mn(2‐(1‐hydrazonoethyl)pyridine)Cl2]n 1D coordination polymer: Synthesis, structural elucidation, and biological studies

Visible Light‐Driven Photocatalytic Transformation of Thiols to Disulfides in Water Catalyzed by Bi2S3

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Product

Resources

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Self‐assembly of unexpected [Mn(2‐(1‐hydrazonoethyl)pyridine)Cl₂]_n 1D coordination polymer: Synthesis, structural elucidation, and biological studies

Visible Light‐Driven Photocatalytic Transformation of Thiols to Disulfides in Water Catalyzed by Bi₂S₃