Versatile Gas/Liquid Microreactors for Industry

Abstract

The design, fabrication, use and scale-out of versatile, multi-channel gas/liquid microreactors, which are suitable for both laboratory and industrial syntheses, are described. Direct fluorination reactions of diethyl malonate and Meldrum's acid using the new microreactor technology were studied to demonstrate the viability of the device for carrying out gas/liquid processes, particularly when using potentially hazardous materials.

Elemental fluorine in organic chemistry (1997–2006)

“…Direct fluorination of malonate esters using microreactor techniques gave a mixture of products arising from substitution of hydrogen atoms attached to carbon adjacent to the ester oxygen as well as the desired methylene site [69]. However, Fig.…”

Elemental fluorine

“…In this paper, we extend the use of our microreactor techniques [7,9,10,17,18] to the synthesis of various fluoroaromatic systems derived from the fluorination of 1,4-and 1,3-disubstituted aromatic substrates. Whilst the fluorination of 1,4-disubstituted systems using batch-wise procedures has been reported earlier [6], effective direct fluorination of highly deactivated 1,3-disubstituted systems bearing two electron withdrawing groups, has not been described previously.…”

Footsteps of a fluorine chemist

“…We have engaged in close collaboration with the F2 Company, to develop the use of selective direct fluorination in industry and, in the course of this work we developed an interest in micro-reactors for synthesis, especially for the control of fluorine. We have summarized our efforts in both of these areas [45][46][47].…”