Versatile hybrid nanoplatforms for treating periodontitis with chemical/photothermal therapy and reactive oxygen species scavenging

A comprehensive exploration of the latest innovations for advancements in enhancing selectivity of nanozymes for theranostic nanoplatforms

“…[4][5][6][7] This characteristic arises from their diverse structures, multiple reactive sites on the surface, abundant redox potential, and non-specific binding to various substrates. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] While their multifunctional enzyme-like properties enable various applications, such as detections, disease therapy, and environmental remediation, [24][25][26][27][28][29][30][31][32][33][34][35][36][37] their non-selective nature poses challenges in certain contexts, particularly for theragnostic nanoplatforms where precise control is crucial. Therefore, the development of more selective nanozymes has become essential to address these limitations and optimize their applications.…”

Scalable Fabrication of Polymeric Composite Microspheres to Inhibit Oral Pathogens and Promote Osteogenic Differentiation of Periodontal Membrane Stem Cells

“…Local therapy using drug carriers is gaining immense attention for treating periodontitis. ,− In particular, drug carriers in the form of biodegradable polymeric microspheres have the capability of filling in the deep periodontal pocket and anatomical complexities of the alveolar bone, thereby reducing the total drug dose, enabling controllable drug release, and exhibiting tailored bioactive property and minimal systemic adverse effects. − Xie et al reported a prolonged local antibacterial strategy based on Ag/TiO 2 /alginate (ATA) hydrogel microspheres, which promoted the generation of reactive oxygen species and O 2 under low-level H 2 O 2 to inhibit Porphyromonas gingivalis . In another study, a drug-loading nanocarrier was made by a hydrophobic lipid core (1, 2-distearoyl- sn -glycero-3-phosphoethanolamine-poly­(ethylene glycol) loaded with alpha-lipoic acid and a hydrophilic shell (poly­(amidoamine) dendrimer encapsulating minocycline hydrochloride) .…”

Three-Pronged Flower-like Nanoplatforms for the Photothermal/Photodynamic/Quaternary Ammonium Salt Synergistic Antibacterial Method and Bioimaging

“…Bacterial infection has been a severe worldwide threat to public safety and health because of emerging antibiotic resistance. − Multidrug resistance is easily sparked by conventional treatment methods. , Thus, creating a unique treatment for damaged skin, organ tissues, and mucous membranes is a great challenge for medical researchers. One of the most efficient sterilization techniques is antibacterial photocatalytic treatment (APCT), a substitute sterilizing technology that has garnered considerable interest.…”