"Versatile Mechanisms of Substituted Quinazolines in Targeted Cancer Therapy"

Abstract

Background:The aim of this review is to provide a minireview on diverse anticancer activities of substituted quinazoline derivatives.Main Body: This minireview provides a correlation between the various mechanisms of action of quinazolines as anticancer and the substitution pattern around the nucleus. Conclusion:The linker group and substitution at N-1, C-2, C-5, and C-6 positions have been found to be the most contributory factors for anticancer activity. This will help in the further design to afford more selective, potent, and multi-target anticancer of 2-substituted benzimidazole-based compounds.