Versatile Polydopamine Platforms: Synthesis and Promising Applications for Surface Modification and Advanced Nanomedicine

Cheng, Wei; Zeng, Xiaowei; Chen, Hongzhong; Li, Zimu; Zeng, Wenfeng; Mei, Lin; Zhao, Yanli

doi:10.1021/acsnano.9b04436

Cited by 797 publications

(475 citation statements)

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“…In general, the synthesis of polymer capsules is rather complex, work-intensive, and therefore expensive [104]. PDA capsules, on the other hand, are comparatively easy to produce [105]. Moreover, the unique properties of PDA combined with drug loading and the simultaneous possibility of ligand grafting add to the benefit of creating capsules of the material.…”

Section: Pda Capsulesmentioning

confidence: 99%

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From Bioinspired Glue to Medicine: Polydopamine as a Biomedical Material

et al. 2020

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Biological structures have emerged through millennia of evolution, and nature has fine-tuned the material properties in order to optimise the structure-function relationship. Following this paradigm, polydopamine (PDA), which was found to be crucial for the adhesion of mussels to wet surfaces, was hence initially introduced as a coating substance to increase the chemical reactivity and surface adhesion properties. Structurally, polydopamine is very similar to melanin, which is a pigment of human skin responsible for the protection of underlying skin layers by efficiently absorbing light with potentially harmful wavelengths. Recent findings have shown the subsequent release of the energy (in the form of heat) upon light excitation, presenting it as an ideal candidate for photothermal applications. Thus, polydopamine can both be used to (i) coat nanoparticle surfaces and to (ii) form capsules and ultra-small (nano)particles/nanocomposites while retaining bulk characteristics (i.e., biocompatibility, stability under UV irradiation, heat conversion, and activity during photoacoustic imaging). Due to the aforementioned properties, polydopamine-based materials have since been tested in adhesive and in energy-related as well as in a range of medical applications such as for tumour ablation, imaging, and drug delivery. In this review, we focus upon how different forms of the material can be synthesised and the use of polydopamine in biological and biomedical applications. platform is highlighted ( Figure 1A). Then, theoretical and experimental proof of the chemical formation of polydopamine-based structures is summarised ( Figure 1B,C). This is then followed by descriptions of the unique (physicochemical) properties of polydopamine. Their applications as adhesive and in energy-related applications are also highlighted ( Figure 1D). Throughout, their wide range of applications in the biomedical field (thanks to their biocompatibility) is thoroughly explained. This includes examples of theranostic and drug delivery applications derived from different types of polydopamine-based configurations: adhesive, particle coating agent, capsule, and NPs/composites, respectively ( Figure 1C,E). Lastly, some challenges to make PDA into functional tools for future clinical applications are envisaged. Materials 2019, 12, x FOR PEER REVIEW 2 of 22polydopamine-based structures is summarised ( Figure 1B,C). This is then followed by descriptions of the unique (physicochemical) properties of polydopamine. Their applications as adhesive and in energy-related applications are also highlighted ( Figure 1D). Throughout, their wide range of applications in the biomedical field (thanks to their biocompatibility) is thoroughly explained. This includes examples of theranostic and drug delivery applications derived from different types of polydopamine-based configurations: adhesive, particle coating agent, capsule, and NPs/composites, respectively ( Figure 1C,E). Lastly, some challenges to make PDA into functional tools for future clinical applicatio...

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Section: Pda Capsulesmentioning

confidence: 99%

“…Various modifications of this approach have been reported to date. For instance, CaCO 3 microparticles, silica NPs, MnCO 3 particles, and polystyrene spheres have recently been used as templates to produce PDA capsules of different shapes and sizes [105].…”

Section: Pda Capsulesmentioning

confidence: 99%

From Bioinspired Glue to Medicine: Polydopamine as a Biomedical Material

et al. 2020

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“…MPDA showed excellent biocompatible and signal enhancement as NPs‐based contrast agents, not only use as single imaging agent but also as a multimodel imaging platform. [ 29,61 ] MPDA that further loaded with active therapeutic ingredients has also been developed for imaging‐guided therapy. This section will give an overview of recent investigations that involve the design, synthesis, and performance of using MPDA for medical imaging and imaging‐guided therapies.…”

Section: Application Of Mpda In Theranosticsmentioning

confidence: 99%

Metal‐Containing Polydopamine Nanomaterials: Catalysis, Energy, and Theranostics

Wang

Zou

et al. 2020

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Polydopamine (PDA) is a major type of artificial melanin material with many interesting properties such as antioxidant activity, free‐radical scavenging, high photothermal conversion efficiency, and strong metal‐ion chelation. The high affinity of PDA to a wide range of metals/metal ions has offered a new class of functional metal‐containing polydopamine (MPDA) nanomaterials with promising functions and extensive applications. Understanding and controlling the metal coordination environment is vital to achieve desirable functions for which such materials can be exploited. MPDA nanomaterials with metal/metal ions as the active functions are reviewed, including their synthesis and metal coordination environment and their applications in catalysis, batteries, solar cells, capacitors, medical imaging, cancer therapy, antifouling, and antibacterial coating. The current trends, limitations, and future directions of this area are also explored.

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“…[22][23][24] With these attractive properties, PDA and its derivatives have shown great potential in a wide range of applications across the biomedical, and materials sciences, as well as in the applied engineering and technology elds. [25][26][27][28][29][30][31] For example, Cai et al recently reported a new kind of PDA-based porous nanoparticles as a drug carrier for synergistic thermo-chemotherapy, therein a signicant promotion effect of near-infrared irradiation on the drug release was observed. 29 In the present work, we chose Sandalore as the model compound and designed a photothermo-responsive nanocarrier for the encapsulation and controlled release of low volatile fragrances.…”

Section: Introductionmentioning

confidence: 99%