Versatile Pt NCs-based chemotherapeutic agents significantly induce the apoptosis of cisplatin-resistant non-small cell lung cancer

Yi, Xin; Huang, Xin; Li, Zengbei; Zhao, Wenda; Wang, Chunlin; Wang, Shaobo; Yue, Xianyang; Hui, Ming; Liu, Hongyun

doi:10.1016/j.bbrc.2019.03.060

Cited by 11 publications

(13 citation statements)

References 27 publications

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“…Especially with the rising enthusiasm for exploring nanomaterial-bound small-molecule chemotherapeutics, these novel nanomedicines may reduce side effects and drug resistance and improve the fight against cancer in oncology patients. Based on the nature of the activation of PEI-Pt NCs in various tumor cells, including non-small cell lung cancer and malignant hematologic diseases, it would be interesting to investigate whether this novel bomb is also effective against ovarian cancer (25,26). We designed a novel platinum anticancer drug, Polyethyleneimine caged platinum nanoclusters (PEI-Pt NCs), a zero-valent platinum based on nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

Biomarking and Induction of Apoptosis in Ovarian Cancer Using Bifunctional Polyethyleneimine-Caged Platinum Nanoclusters

et al. 2022

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According to the 2020 GLOBOCAN Global Cancer Women’s Cancer Data, ovarian cancer is the eighth most common tumor in humans. Still, its mortality rate ranks first among all gynecological tumors, with a 5-year survival rate of 30% to 50%. Widespread clinical use of platinum-based drugs has improved survival outcomes in patients with ovarian cancer, but organ toxicity and drug resistance hinder their anticancer effects. In particular, the resistance to platinum drugs is an important reason for ovarian cancer’s high recurrence rate and mortality. With the development of chemotherapeutic drugs synthesized by nanomaterials in the biomedical field, we developed bifunctional ultrafine polyethyleneimine caged platinum nanoclusters (PEI-Pt NCs) to improve the dilemma of platinum drugs. This study aimed to elucidate the antitumor effect of PEI-Pt NCs in OC. First, as observed by confocal microscopy, Pt NCs entered OC cells in a dose-dependent manner and accumulated on the surface of the nuclear membrane and in the nucleus. Subsequently, through cck8, ki-67 immunofluorescence, wound healing assay, transwell assay, clone formation assay, flow cytometry, tunel staining, and western blotting assay, it was confirmed that PEI-Pt NCs could inhibit the proliferation and migration and induce the apoptosis of ovarian cancer cells. PEI-Pt NCs can be used as fluorescent markers for systemic bioimaging of ovarian cancer, showing great potential in diagnosing and treating ovarian cancer, and making a specific contribution to solving the dilemma of platinum-based drug therapy for OC.

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Section: Discussionmentioning

confidence: 99%

Biomarking and Induction of Apoptosis in Ovarian Cancer Using Bifunctional Polyethyleneimine-Caged Platinum Nanoclusters

et al. 2022

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“…As illustrated in Figure S4, treatment with HA-Pt NCs-NH 2 resulted in the downregulation of c-myc (p < 0.001), which may be partially responsible for the cell cycle arrest and apoptotic tendency of the H1299 cells. Recent studies [18] have shown that Pt NCs, a novel Pt-based chemotherapeutic agent, have the superior inhibitory effects on tumor cell proliferation and induction of apoptosis, possibly via the activation of p53 protein and related signaling pathways. The mechanism of apoptosis is due to the rapid breakdown of Pt nitrogen compounds into corrosive Pt ions, which tends to bind with DNA and proteins, leading to the destruction of DNA.…”

Section: Induced Apoptosis Mechanism Of Ha-pt Ncs-nh 2 For Nsclc Cellsmentioning

confidence: 99%

“…Compared to cisplatin, Pt NCs-based chemotherapeutic agents significantly inhibited the proliferation of NSCLC cells and showed superior inhibitory and apoptotic effects on cisplatin-resistant A549/DDP cells. [18] Therefore, Pt NCs apply an inspiring probability to achieve targeted identification and therapy for NSCLC via forming HA-functioned Pt NCs bioconjugates.…”

Section: Introductionmentioning

confidence: 99%

Distinguishable Targeting of Non‐Small Cell Lung Cancer Using Hyaluronan Functionalized Platinum Nanoclusters and Their Inhibition Behaviors of Proliferation, Invasion, Migration

et al. 2021

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Lung cancer is the leading cause of cancer deaths worldwide and most cancer patients receiving conventional chemotherapy suffer from severe side effects due to the non‐selective effects of chemotherapeutic drugs on normal cells. Targeted nanomaterials can obtain excellent accumulation at the tumor site through their active or passive targeting mechanisms, thereby reducing the toxicity of the drugs in various ways. In this study, hyaluronic acid (HA) which could specifically bind to CD44 on the surface of tumor cells, was used to modify amine‐caged platinum nanoclusters (Pt NCs‐NH2) to obtain targeting HA‐Pt NCs‐NH2. Based on the differential expression of CD44 on the surface of three lung cells (non‐small cell lung cancer cell H1299, small cell lung cancer cell H446, and embryonic lung fibroblast HFL1), HA‐Pt NCs‐NH2 can differentially enter the three cells and achieve their targeting of non‐small cell lung cancer cell (NSCLC) cells. Pt NCs significantly inhibited the proliferation, migration and invasion of NSCLC cells and induced their apoptosis in comparison of classical cisplatin and carboplatin, showing a bright future in early diagnosis and treatment of NSCLC.

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“…This distinction gives an opportunity to achieve the specific labelling of hematopoietic cells during the disease diagnosis. Recently, we extended this fluorescent probe to label the lung cancer [187]. The classical human lung adenocarcinoma cells were chosen to examine their biological imaging ability (Figure 8).…”

Section: Biological Applications Of Platinum Nanoclustersmentioning

confidence: 99%

“…The problem of drug resistance seriously affects the chemotherapy efficiency and survival rate of patients during the treatment with chemotherapy drugs due to multiple mechanism, such as the lack of effective drug concentration in tumour cells, reduction of drug activity, cell apoptosis changes, and DNA repair pathways. The experimental results illustrated that Pt NCs-based anticancer drug could achieve the excellent induced apoptosis in both cisplatin-resistant A549/DDP and non-cisplatin-resistant A549 cells [187]. More interesting is that cisplatin-resistant A549/DDP showed the superior inhibitory and apoptotic effects than non-cisplatin-resistant A549 cells by the way of activating p53 protein and the related signalling pathway, which could be proved through the apparent endocytosis behaviour by the nucleus of cisplatin-resistant A549/DDP cells.…”

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confidence: 96%

Recent Advances in the Synthesis, Properties, and Biological Applications of Platinum Nanoclusters

Huang

et al. 2019

Journal of Nanomaterials

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Noble metal nanoclusters (M NCs), defined as an aggregation of a few to tens of atoms, are considered a borderline between atoms and metal nanoparticles (M NPs), which tends to exhibit molecule-like behaviours such as discrete electronic state and size-dependent fluorescence. In the past decades, gold and silver nanoclusters (Au NCs and Ag NCs) have been massively explored and utilized in the field of industrial catalysis, optoelectronic devices, biological imaging, environmental detection, clinical diagnoses, and treatment. The analogue of Au and Ag NCs and platinum nanoclusters (Pt NCs), especially their biological applications, is relatively and rarely discussed. This review firstly investigates the synthetic methodology of Pt NCs including template-assisted and template-free approaches and then introduces their unique optical, catalytic, and thermal properties. Particular importance here is the biological applications of Pt NCs such as the bioimaging of various cells as a preferred fluorophore in contrast to traditional fluorescent markers (e.g., organic dye, semiconductor quantum dots, and fluorescent proteins), the usage of Pt NCs-based antitumour drugs as a new class chemotherapeutics for malignant tumour therapy, and the utilization of antibacteria as an alternative of Ag-based antibacterial agent. On the whole, the development of Pt NCs has already gained delectable progress; however, the study of ultrafine Pt NCs is at the beginning stage and there are still plenty of challenges like synthesis of near-infrared (NIR) fluorescent Pt NCs, the explicit signal pathway of cell apoptosis, and attempt in diverse biological applications that need to be urgently tackled in future.

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Versatile Pt NCs-based chemotherapeutic agents significantly induce the apoptosis of cisplatin-resistant non-small cell lung cancer

Cited by 11 publications

References 27 publications

Biomarking and Induction of Apoptosis in Ovarian Cancer Using Bifunctional Polyethyleneimine-Caged Platinum Nanoclusters

Biomarking and Induction of Apoptosis in Ovarian Cancer Using Bifunctional Polyethyleneimine-Caged Platinum Nanoclusters

Distinguishable Targeting of Non‐Small Cell Lung Cancer Using Hyaluronan Functionalized Platinum Nanoclusters and Their Inhibition Behaviors of Proliferation, Invasion, Migration

Recent Advances in the Synthesis, Properties, and Biological Applications of Platinum Nanoclusters

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