Versatility of mesenchymal stem cell-derived extracellular vesicles in tissue repair and regenerative applications

Williams, Taylor; Salmanian, Ghazaleh; Burns, Morgan; Maldonado, Vitali; Smith, Emma; Porter, Ryan M.; Song, Young Hye; Samsonraj, Rebekah M.

doi:10.1016/j.biochi.2022.11.011

Cited by 21 publications

(11 citation statements)

References 163 publications

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“…The extracellular vesicles (EVs) from MSCs are released and contact with the target recipient cell. Afterward, the damaged lung tissue is protected from inflammatory injury and renewed ( 74 , 75 ). When MSCs were co-cultured with injured lung tissue in vitro , 44 kinds of proteins were secreted to accelerate airway epithelium repair by stimulating migration, proliferation, and differentiation.…”

Section: Discussionmentioning

confidence: 99%

Successful salvage of a severe COVID-19 patient previously with lung cancer and radiation pneumonitis by mesenchymal stem cells: a case report and literature review

Huang,

Tan,

Xie

et al. 2024

Front. Immunol.

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During the COVID-19 pandemic, elderly patients with underlying condition, such as tumors, had poor prognoses after progressing to severe pneumonia and often had poor response to standard treatment. Mesenchymal stem cells (MSCs) may be a promising treatment for patients with severe pneumonia, but MSCs are rarely used for patients with carcinoma. Here, we reported a 67-year-old female patient with lung adenocarcinoma who underwent osimertinib and radiotherapy and suffered from radiation pneumonitis. Unfortunately, she contracted COVID-19 and that rapidly progressed to severe pneumonia. She responded poorly to frontline treatment and was in danger. Subsequently, she received a salvage treatment with four doses of MSCs, and her symptoms surprisingly improved quickly. After a lung CT scan that presented with a significantly improved infection, she was discharged eventually. Her primary disease was stable after 6 months of follow-up, and no tumor recurrence or progression was observed. MSCs may be an effective treatment for hyperactive inflammation due to their ability related to immunomodulation and tissue repair. Our case suggests a potential value of MSCs for severe pneumonia that is unresponsive to conventional therapy after a COVID-19 infection. However, unless the situation is urgent, it needs to be considered with caution for patients with tumors. The safety in tumor patients still needs to be observed.

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Section: Discussionmentioning

confidence: 99%

Successful salvage of a severe COVID-19 patient previously with lung cancer and radiation pneumonitis by mesenchymal stem cells: a case report and literature review

Huang,

Tan,

Xie

et al. 2024

Front. Immunol.

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“…Although several subtypes of nano-vesicles are currently recognized, due to the recent bibliographic studies (2002-2021), two terms, “exosomes” and “extracellular vesicles”, are yet the most frequent keywords applied to describe the role of these cell-derived membranous nano-vesicles in autoimmune diseases ( 84 , 85 ). Despite the initial trend, it is now evidenced that the impact of EV subtypes and their versatility is so critical compared to what it inferred at first ( 86 , 87 ) and should not be underestimated during designing and performing future pre-clinical experiments and clinical trials. Here, following the International Society for Extracellular Vesicles (ISEV) consensus recommendation ( 88 ), we apply the term “extracellular vesicles” as the representative for the nano-sized natural and non-replicative particles focusing on membranous exosomes and ectosomes, which are produced by almost all cell types ( 68 , 76 , 89 – 92 ).…”

Section: Extracellular Vesicles a New Therapeutic Paradigm For Autoim...mentioning

confidence: 99%

“…One good reason favoring the local administration of EVs is the lower amount required, making their utilization much more cost-effective. Furthermore, their gradual and sustained release following the administration is a positive point ( 87 ). Moreover, the application of scaffolds/biomaterials increases the bioavailability, homing, and/or biocompatibility of EVs at the site of injection, while they are also effective in avoiding the side effects of the injection procedure ( 159 ).…”

Section: Extracellular Vesicles a New Therapeutic Paradigm For Autoim...mentioning

confidence: 99%

Extracellular vesicles and their cells of origin: Open issues in autoimmune diseases

et al. 2023

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The conventional therapeutic approaches to treat autoimmune diseases through suppressing the immune system, such as steroidal and non-steroidal anti-inflammatory drugs, are not adequately practical. Moreover, these regimens are associated with considerable complications. Designing tolerogenic therapeutic strategies based on stem cells, immune cells, and their extracellular vesicles (EVs) seems to open a promising path to managing autoimmune diseases’ vast burden. Mesenchymal stem/stromal cells (MSCs), dendritic cells, and regulatory T cells (Tregs) are the main cell types applied to restore a tolerogenic immune status; MSCs play a more beneficial role due to their amenable properties and extensive cross-talks with different immune cells. With existing concerns about the employment of cells, new cell-free therapeutic paradigms, such as EV-based therapies, are gaining attention in this field. Additionally, EVs’ unique properties have made them to be known as smart immunomodulators and are considered as a potential substitute for cell therapy. This review provides an overview of the advantages and disadvantages of cell-based and EV-based methods for treating autoimmune diseases. The study also presents an outlook on the future of EVs to be implemented in clinics for autoimmune patients.

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“…A recent basic study indicated that the tissue repair function of MSCs is mainly exerted by paracrine secretion of bioactive molecules ( Liang, et al, 2014 ; Najar, et al, 2021 ; Williams et al, 2022 ). As an important paracrine factor, extracellular vesicles (EVs) are lipid bilayer nanovesicles secreted by living cells and their classification and nomenclature were formulated by the International Society of Extracellular Vesicles (ISEV) ( Boere, et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Extracellular vesicles secreted by human gingival mesenchymal stem cells promote bone regeneration in rat femoral bone defects

Wang

Liu²,

Yang³

et al. 2023

Front. Bioeng. Biotechnol.

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Extracellular vesicles (EVs), important components of paracrine secretion, are involved in various pathological and physiological processes of the body. In this study, we researched the benefits of EVs secreted by human gingival mesenchymal stem cells (hGMSC-derived EVs) in promoting bone regeneration, thereby providing new ideas for EVs-based bone regeneration therapy. Here, we successfully demonstrated that hGMSC-derived EVs could enhance the osteogenic ability of rat bone marrow mesenchymal stem cells and the angiogenic capability of human umbilical vein endothelial cells. Then, femoral defect rat models were created and treated with phosphate-buffered saline, nanohydroxyapatite/collagen (nHAC), a grouping of nHAC/hGMSCs, and a grouping of nHAC/EVs. The results of our study indicated that the combination of hGMSC-derived EVs and nHAC materials could significantly promote new bone formation and neovascularization with a similar effect to that of the nHAC/hGMSCs group. Our outcomes provide new messages on the role of hGMSC-derived EVs in tissue engineering, which exhibit great potential in bone regeneration treatment.

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Versatility of mesenchymal stem cell-derived extracellular vesicles in tissue repair and regenerative applications

Cited by 21 publications

References 163 publications

Successful salvage of a severe COVID-19 patient previously with lung cancer and radiation pneumonitis by mesenchymal stem cells: a case report and literature review

Successful salvage of a severe COVID-19 patient previously with lung cancer and radiation pneumonitis by mesenchymal stem cells: a case report and literature review

Extracellular vesicles and their cells of origin: Open issues in autoimmune diseases

Extracellular vesicles secreted by human gingival mesenchymal stem cells promote bone regeneration in rat femoral bone defects

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