2005
DOI: 10.1016/j.humpath.2004.10.010
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Versican in nonsmall cell lung cancer: relation to hyaluronan, clinicopathologic factors, and prognosis

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Cited by 88 publications
(80 citation statements)
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“…44 This suggests that versican might act as a molecular sink, trapping CCL5 and CCL21, and offers We also have associated the expression of versican with relevant clinical parameters such as lymph node metastasis, tumor size, infiltration depth and vascular space involvement. Although for breast, cervical, prostate and other tumor types, increased versican expression has been associated with relapse and poor clinical outcome, 12,16,17,19,20,36,39,45,46 we could not demonstrate this association in our cervical cancer cohort. To exclude that this was related to the scoring system, we have also scored our data according to the method described by Kodama et al 20 (data not shown), but in this case also no statistically significant association was found.…”
Section: Versican In Cervical Carcinomamentioning
confidence: 63%
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“…44 This suggests that versican might act as a molecular sink, trapping CCL5 and CCL21, and offers We also have associated the expression of versican with relevant clinical parameters such as lymph node metastasis, tumor size, infiltration depth and vascular space involvement. Although for breast, cervical, prostate and other tumor types, increased versican expression has been associated with relapse and poor clinical outcome, 12,16,17,19,20,36,39,45,46 we could not demonstrate this association in our cervical cancer cohort. To exclude that this was related to the scoring system, we have also scored our data according to the method described by Kodama et al 20 (data not shown), but in this case also no statistically significant association was found.…”
Section: Versican In Cervical Carcinomamentioning
confidence: 63%
“…Versican expression was normalized against a household gene (EEF1A1). 12,13,[16][17][18]20,23,34,[36][37][38][39] As the composition of the ECM influences the migration of inflammatory cells, 33 we have also measured the association between inflammatory cells and versican expression. Despite the reported production of versican isoforms V0 and V1 by human leukemic monocytes 40 and the reported …”
Section: Discussionmentioning
confidence: 99%
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“…Studies on chondroitin sulfate proteoglycans have shown that they play important roles in cancer biology, and may be useful prognostic factors in breast, lung, ovarian and skin cancers. 10,13,14,[29][30][31] Several immunohistochemical studies focusing on the sulfated chondroitin chain have shown that high stromal levels of this molecule is associated with a poor outcome in patients with early-stage prostate cancer. 19,20 Furthermore, increased expression of the core proteins of versican in the peritumoral stroma, and PTEN (two chondroitin sulfate proteoglycans) has also been reported to be predictive of poor prognosis in early-stage prostate cancer patients.…”
Section: Discussionmentioning
confidence: 99%
“…These have been found to regulate cancer cell behavior and affect disease outcome in a number of malignancies, including cancers of the lung, breast, ovary, mouth, pharynx and skin. [10][11][12][13][14][15] Previous studies have shown that expression of versican, a chondroitin sulfate proteoglycan, is increased in prostate cancer and inhibits cancer cell adhesion to fibronectin in the stromal matrix. 16,17 Furthermore, high performance liquid chromatography analysis of glycosaminoglycans extracted from prostate cancer samples revealed that chondroitin-6-sulfate and dermatan sulfate were the predominantly upregulated components.…”
mentioning
confidence: 99%