Considering on-going global deforestation and the increased demand for raw materials in all wood-processing sectors it is necessary to seek and employ alternative resources. Particularly for the wood-based panel industry (partial) substitution of conventional wood material by agricultural residues, for example, cereal straws or suitable lignocellulose-based raw materials may proof to be a resource of increasing importance. If some economic conditions (transport, storage, pre-treatment costs) are favourable, the use of these residues will satisfy the different aspects of sustainable management. The material utilization of renewable raw materials for high quality products generates high added value for both producers and rural suppliers. Furthermore, negative impacts on the environment (air pollution, high water consumption) due to conventional waste disposal and overexploitation of forests are reduced. An overview of potentials, development and challenges in the field of panel production made from agro-based lignocelluloses is provided