Verstrecktes Polyethylen (UHMWPE) - eine neue Werkstoffmodifikation zur Abriebsminimierung beim künstlichen Kniegelenksersatz - Stretched Polyethylene (UHMWPE) - a New Material Modification that Reduces Wear in Total Knee Arthroplasty

Wirtz, D. C.; Schopphoff, E.; Weichert, Dieter; Niethard, F. U.

doi:10.1515/bmte.2001.46.12.338

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…The ultrahigh-molecular weight polyethylene (UHMWPE) used in the ABG I system has been extensively enhanced as a result of reports about wear and accelerated aging [31, 32]. The modified processing and radiation sterilization in nitrogen with postannealing led to amplification of the PE cross-linking and reduction of potential degradation in the ABG II system.…”

Section: Introductionmentioning

confidence: 99%

Early Polyethylene Wear and Excessive Acetabular Granuloma in an Uncemented HA-Coated Total Hip Arthroplasty—Midterm Results of a Prospective Study

Ohnsorge

Davis

Maus

et al. 2006

HSS Journal®: The Musculoskeletal Journal of Hospital for Speci

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This is a prospective review of 135 HAcoated ABG I total hip arthroplasty (THA) systems with a mean clinical and radiographic follow-up of 8.5 years. The 5-year survival rate was 85%, but 22% of the patients were dissatisfied. Revision THA was already indicated in 28% of the patients, with 26% indicated for cup loosening. PE wear was detected by x-ray in 42%. Disproportionate substantial wear with an average linear loss of 2.6 mm at the inner rim of the insert was observed in 23% of the cases. The mean annual wear rate was calculated 0.1-0.25 mm/year. Laboratory examination of the retrieved PE revealed polishing, cracks, and subsurface delamination. Radiographic evidence of acetabular cysts were found to be excessive granuloma during surgery. Polarization microscopy revealed debris particles phagocytized by reticuloendothelial cells. Results confirm the general opinion that aseptic osteolysis is a cell-mediated process driven by the presence of particles generated from wear debris. The findings also suggest that the main reasons for the failure of the first-generation ABG hip system were an insufficient locking mechanism and poor PE congruency, and not solely poor PE quality.

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Section: Introductionmentioning

confidence: 99%

Early Polyethylene Wear and Excessive Acetabular Granuloma in an Uncemented HA-Coated Total Hip Arthroplasty—Midterm Results of a Prospective Study

Ohnsorge

Davis

Maus

et al. 2006

HSS Journal®: The Musculoskeletal Journal of Hospital for Speci

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“…13 Introducing molecular chain orientation in UHMWPE by uniaxial compression or stretching can enhance the wear resistance as compared to the unoriented UHMWPE in water 14 and in the dry state. 15 With bovine serum albumin as lubricant, however, the improvement of wear resistance diminishes. 16 This indicates the crucial role of the boundary layer between the UHMWPE surface and the wear counterpart mediated by the lubricating synovial liquid and the adsorbed protein layer.…”

mentioning

confidence: 99%

How the Surface Nanostructure of Polyethylene Affects Protein Assembly and Orientation

et al. 2011

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Protein adsorption plays a key role in the biological response to implants. We report how nanoscale topography, chemistry, crystallinity, and molecular chain anisotropy of ultrahigh molecular weight polyethylene (UHMWPE) surfaces affect the protein assembly and induce lateral orientational order. We applied ultraflat, melt drawn UHMWPE films to show that highly oriented nanocrystalline lamellae influence the conformation and aggregation into network structures of human plasma fibrinogen by atomic force microscopy with unprecedented clarity and molecular resolution. We observed a transition from random protein orientation at low concentrations to an assembly guided by the UHMWPE surface nanotopography at a close to full surface coverage on hydrophobic melt drawn UHMWPE. This assembly differs from the arrangement at a hydrophobic, on the nanoscale smooth UHMWPE reference. On plasma-modified, hydrophilic melt drawn UHMWPE surfaces that retained their original nanotopography, the influence of the nanoscale surface pattern on the protein adsorption is lost. A model based on protein-surface and protein-protein interactions is proposed. We suggest these nanostructured polymer films to be versatile model surfaces to provide unique information on protein interactions with nanoscale building blocks of implants, such as nanocrystalline UHMWPE lamellae. The current study contributes to the understanding of molecular processes at polymer biointerfaces and may support their future design and molecular scale tailoring.

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Single‐Molecule Tracking of Fibrinogen Dynamics on Nanostructured Poly(ethylene) Films

Kastantin

Keller

Schwartz

2012

Adv Funct Materials

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Using fibrinogen (Fg) protein as a probe molecule, mapping using accumulated probe trajectories (MAPT) is performed on nanostructured melt‐drawn high‐density poly(ethylene) (HDPE) films composed of well‐oriented crystalline patches separated by amorphous regions. The spatially grouped molecular trajectories allow for identification of regions with distinct surface properties (i.e., crystalline vs. amorphous) while simultaneously determining the characteristic dynamic protein behavior within those regions. In the presence of solution with a sufficiently high Fg concentration, discrete patches of a dense, ordered protein layer form (presumably on crystalline HDPE regions), leading to a dramatic rise in the surface residence time (by more than two orders of magnitude) of molecules incorporated into the film. Within this ordered Fg layer, individual molecules exhibit slow anisotropic lateral diffusion; the mobility is restricted by the nanostructure boundaries of the underlying HDPE. On HDPE films at low Fg surface coverage, or on films that have been rendered hydrophilic with Ar plasma, short surface residence times and fast, isotropic diffusion are observed. These results demonstrate the ability of spatially resolved single‐molecule tracking to provide mechanistic information about biomolecule‐surface interactions in a highly heterogeneous environment.

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Verstrecktes Polyethylen (UHMWPE) - eine neue Werkstoffmodifikation zur Abriebsminimierung beim künstlichen Kniegelenksersatz - Stretched Polyethylene (UHMWPE) - a New Material Modification that Reduces Wear in Total Knee Arthroplasty

Cited by 3 publications

References 4 publications

Early Polyethylene Wear and Excessive Acetabular Granuloma in an Uncemented HA-Coated Total Hip Arthroplasty—Midterm Results of a Prospective Study

Early Polyethylene Wear and Excessive Acetabular Granuloma in an Uncemented HA-Coated Total Hip Arthroplasty—Midterm Results of a Prospective Study

How the Surface Nanostructure of Polyethylene Affects Protein Assembly and Orientation

Single‐Molecule Tracking of Fibrinogen Dynamics on Nanostructured Poly(ethylene) Films

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