Versuche einer chemischen Charakterisierung und Reindarstellung des Trichophytins (des aktiven, antigenen Prinzips pathogener Hautpilze)

Bloch, Br.; Labouchère, A.; Schaaf, Fritz

doi:10.1007/bf01826383

Cited by 49 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, the slight residual activity of fraction G should undoubtedly be attributed to contamination with the highly potent fraction E, e. g. precipitation of E (house dust allergen) from saturated ammonium sulphate solution obviously is not complete. A similar phenomenon has been reported in the case of trichophytin (12). It may also explain the failure of V a n n ie r a n d C a m p b e l l (4) to remove all protein N from their preparation*.…”

Section: E Results and Discussionmentioning

confidence: 67%

Purification and Properties of House Dust Allergen

Berrens¹,

Young²

1961

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Section: E Results and Discussionmentioning

confidence: 67%

Purification and Properties of House Dust Allergen

Berrens¹,

Young²

1961

Int Arch Allergy Immunol

View full text Add to dashboard Cite

“…trichophytin [9], Likewise, animals experimentally infected with dermatophytes show similar trichophytin hypersensitivity. Various kinds of trichophytins cross-react whether they are produced from the same organism, different strains, different species, or dif ferent dermatophyte genera [4], The major antigenic struc ture in trichophytin consists of a specific glycoprotein [10].…”

Section: Trichophytinmentioning

confidence: 73%

Inflammation and Immunity in Dermatophytosis

Tagami¹,

Kudoh²,

Takematsu³

1989

Dermatology

View full text Add to dashboard Cite

Infections by dermatophytes (dermatophytosis) naturally stimulate the immune system as in those by other microorganisms to induce various immunological phenomena. However, differing from other infections, the infecting organisms cannot become a direct target of antibody response or phagocytosis because they reside only in the barrier membrane of the body surface, i.e. in the stratum corneum.Thus, the immunity against dermatophytes is relative as compared with the absolute one noted in other infections such as measles and mumps. In dermatophytosis, a unique behavior of the epidermis as noted in contact dermatitis plays an important role in the defense against infection. Dermatitic changes induced by fungal products, particularly those due to contact sensitivity to a fungal antigen, trichophytin, enhance epidermopoiesis, which leads to increased turnover of the epidermis with their resultant elimination from the skin surface. Furthermore, the dermatophytes in the stratum corneum provoke transepidermal leukocyte chemotaxis by generating chemotactic C5a anaphylatoxin in exudating serum via alternative complement pathway activation in addition to a release of low molecular weight chemotactic factors. Such neutrophilic migration with the formation of subcorneal pustules also enhances epidermal proliferation as in psoriasis.

show abstract

“…Interest in the separation and characterization of antigenic components from dermatophytes began with the work of Bloch et al (30).…”

Section: Antigenic Compositionmentioning

confidence: 99%