Versuche zur quantitativen Erfassung der bei der Resorption von Neutralfett eintretenden Spaltung

Bernhard, Karl; Wagner, H.; Ritzel, G

doi:10.1002/hlca.19520350442

Cited by 39 publications

(9 citation statements)

References 9 publications

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“…The origin of the fecal fat and the relative concentrations from dietary and endogenous sources were not studied here, although it has been suggested that endogenous fat excretion may be increased in animals with biliary diversion (50,51).…”

Section: Resultsmentioning

confidence: 99%

Effects of controlled interruption of the enterohepatic circulation of bile salts by biliary diversion and by ileal resection on bile salt secretion, synthesis, and pool size in the rhesus monkey

Dowling¹,

Mack²,

Small³

1970

J. Clin. Invest.

239

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ABSTRA CT The effects of controlled interruption of the enterohepatic circulation (EHC) of bile salts by biliary diversion on bile volume, bile salt secretion and synthesis rates, bile salt pool size, and the relationship to fecal fat excretion were studied in 16 rhesus monkeys.Bile from a chronic bile fistula was returned to the intestine through an electronic stream-splitter which, by diverting different percentages of bile to a collecting system, provided graded and controlled interruption of the EHC.The increase in hepatic bile salt synthesis in response to interruption of the EHC was limited and reached a maximum rate at 20% interruption of the EHC. Up to this level of biliary diversion, the increased hepatic synthesis compensated for bile salt loss so that bile salt secretion and pool size were maintained at normal levels. With diversion of 33% or more, there was no further increase in hepatic bile salt synthesis to compensate for external loss, and as a result there was diminished bile salt secretion, a reduction in bile salt pool size, and steatorrhea was observed.

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Section: Resultsmentioning

confidence: 99%

Effects of controlled interruption of the enterohepatic circulation of bile salts by biliary diversion and by ileal resection on bile salt secretion, synthesis, and pool size in the rhesus monkey

Dowling¹,

Mack²,

Small³

1970

J. Clin. Invest.

239

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“…This step is irreversible in that glycerol from ingested triglyceride is not reacylated in the lumen (49,50). Incubation of triglyceride with high concentrations of pancreatic lipase in vitro results in complete digestion of triglyceride to fatty acid and glycerol (51,52).…”

Section: Fat Digestion In Manmentioning

confidence: 99%

The Intraluminal Phase of Fat Digestion in Man: The Lipid Content of the Micellar and Oil Phases of Intestinal Content Obtained during Fat Digestion and Absorption*

Hofmann¹,

Borgström²

1964

J. Clin. Invest.

413

135

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“…Reiser, Bryson, Carr & Kuiken (1952) claimed that 25-45% of triglyceride is completely hydrolysed to glycerol, the remaining 55-75 % being hydrolysed to monoglyceride: this is equivalent to 75-80 % of the fatty acid being liberated. Bernhard, Wagner & Ritzel (1952) also found that 24-53 % of the glycerol of triglyceride eaten must have been liberated during digestion. Borgstr6m (1954 a) has shown that di-and triglycerides can be synthesized from monoglyceride during digestion, a finding which throws some doubt on the validity of deductions from this type of experiment.…”

Section: University Ofmentioning

confidence: 93%

The composition of lipid from jejunal contents of the dog after a fatty meal

Dowse¹,

Saunders²,

Schofield³

1956

The Journal of Physiology

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It is generally accepted that lipase splits fat to some extent in the intestine, but the degree of lipolysis is still uncertain. It has been suggested (Frazer, 1946) that not more than 30 % of the total fatty acid is liberated in the intestine and that no glycerol is formed: and it was also maintained that more than 60 % of ingested fat is absorbed as unsplit triglyceride in the form of particles of less than 05,u in diameter, stabilized as an emulsion by monoglyceride, fatty acid and bile salts. The evidence adduced in support of these contentions was largely indirect, being based on in vitro studies of lipolysis, on the composition of fat from the intestinal contents of rats after fat administration, on in vitro studies of emulsification and on changes in chylomicron counts in blood during fat absorption.In vitro studies on lipolysis have been carried out by Desnuelle who summarized (1951) the results obtained by his group. They found that at pH 8 the extent of fat hydrolysis by pancreatic extracts was low, except in the presence of calcium salts and of large amounts of bile, when hydrolysis proceeded to completion. Borgstr6m (1952) used as a source of lipase a physiological mixture of bile and pancreatic juice obtained by cannulating the duodenal papilla of the rat and subsequently adjusted to pH 6-5. Added corn oil was rapidly hydrolysed, 50 % of the fatty acid being liberated in 3 hr and 70 % in 6 hr.Many workers on fat digestion have analysed the fat obtained from intestinal contents of animals killed after having been fed with olive oil by stomach tube. Desnuelle & Constantin (1952) found 16-24% fatty acid, Borgstrom (1952) found 37 and 43 % and Mattson, Benedict, Martin & Beck (1952) 15-25% in fat from rats killed 3 hr after feeding on olive oil. In similar experiments with dogs Desnuelle & Constantin (1952) found 17 % fatty acid 3 hr after feeding and 49 % after 5 hr. These analyses are all of the unabsorbed 33-2 C. M. DOWSE AND OTHERS residue of fat in the intestine and can provide little evidence as to the degree of lipolysis of absorbed material.Blankenhorn & Ahrens (1955) used a continuous aspiration technique to obtain jejunal contents throughout the whole period offat digestion in humans.They found that 58 and 60 % of the fat isolated was fatty acid. This method of collection provides more valuable evidence as to events in the intestine than the collection of intestinal contents at a fixed time interval after fat feeding.Several workers have fed rats on fats labelled in the fatty acid and/or glycerol part of the molecule, collected lymph and deduced the amount of lipolysis which had taken place in the intestine from distribution of labelled material in the fat isolated from lymph. Favarger, Collet & Cherbuliez (1951) deduced that the maximum hydrolysis varied between 12 and 45 %. Reiser, Bryson, Carr & Kuiken (1952) claimed that 25-45% of triglyceride is completely hydrolysed to glycerol, the remaining 55-75 % being hydrolysed to monoglyceride: this is equivalent to 75-80 % of the fatt...

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Versuche zur quantitativen Erfassung der bei der Resorption von Neutralfett eintretenden Spaltung

Abstract: An investigation was carried out on the absorption of neutral fats, with the purpose of studying the hydrolysis taking place during this process.

Cited by 39 publications

References 9 publications

Effects of controlled interruption of the enterohepatic circulation of bile salts by biliary diversion and by ileal resection on bile salt secretion, synthesis, and pool size in the rhesus monkey

Effects of controlled interruption of the enterohepatic circulation of bile salts by biliary diversion and by ileal resection on bile salt secretion, synthesis, and pool size in the rhesus monkey

The Intraluminal Phase of Fat Digestion in Man: The Lipid Content of the Micellar and Oil Phases of Intestinal Content Obtained during Fat Digestion and Absorption*

The composition of lipid from jejunal contents of the dog after a fatty meal

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