“…Since the first clinically applied spinal navigation technique in 1995, 1-3 navigation technology, especially spinal navigation, has been constantly evolving, providing innovative ways to accurately diagnose, plan, simulate, and perform surgical procedures. [4][5][6][7] Although the two general methods of preoperatively acquired CT imaging-based navigation 2,3 and intraoperatively acquired (2D/3D fluoroscopy) imaging navigation 2,3,[8][9][10][11] are still in use today, the integration of augmented reality (AR), virtual reality, and mixed reality 12 into navigation systems is the subject of new innovative developments, which also improve the spatial awareness of surgeons and create an immersive, interactive experience. 13 Mixed reality is attractive in that it is an extension of AR and allows real and virtual elements to interact in an environment.…”