Vertebral artery hypoplasia influences age-related differences in blood flow of the large intracranial arteries

Miller, Kathleen B.; Gallo, Samuel J.; Rivera‐Rivera, Leonardo A.; Corkery, Adam T.; Howery, Anna J.; Johnson, Sterling C.; Rowley, Howard A.; Wieben, Oliver; Barnes, Jill N.

doi:10.1016/j.nbas.2021.100019

Cited by 4 publications

(3 citation statements)

References 52 publications

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“…However, it may be observed asymptomatically in healthy individuals as well. 11 This study also described that there were no differences in the age of onset of symptomatic clinical manifestations in cerebral artery hypoplasia and general stroke population. Therefore, it was thought that cerebral artery hypoplasia acted more as a predisposing factor for other cardiovascular risk factors rather than a single independent risk factor, for symptomatic clinical manifestations.…”

Section: Discussionmentioning

confidence: 58%

“…A study regarding the cerebral blood flow changes in VAH described that VAH was associated with lower internal carotid artery (anterior circulation) blood flow in older subjects whereas non-VAH was associated with lower basilar artery (posterior circulation) blood flow in older subjects. 11 The study of cerebral blood flow in cerebral artery hypoplasia was beyond the scope of this study.…”

Section: Discussionmentioning

confidence: 99%

“…13 In respect to cardiovascular risk factors, decreased vessel lumen may potentiate slow flow and high sheer stress locally, which increases the susceptibility of atherosclerosis, stenosis, or occlusion, and the risk of ischemic stroke due to atherosclerosis at the respective region, as well as disturbance in general cerebral blood flow at anterior or posterior circulation. 11,14 The role of cerebral artery hypoplasia in symptomatic clinical manifestations had largely been observed in VAH, which is a common congenital anatomical variation. However, it may be observed asymptomatically in healthy individuals as well.…”

Section: Discussionmentioning

confidence: 99%

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The prevalence, clinical characteristics, and brain MRI changes in intracranial artery hypoplasia: a retrospective single-center cross-sectional study

Usman,

Pariama,

Aiko

et al. 2023

Int J Res Med Sci

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reduced cerebral blood flow, increased atherosclerosis, and aneurysm formation. This study aimed to describe the profile of vertebral artery hypoplasia (VAH), anterior CAH (ACAH), and posterior CAH (PCAH) in symptomatic subjects. Methods: This was a retrospective cross-sectional study using medical record in a secondary private hospital in Jakarta, Indonesia, in January-December 2022. The inclusion criteria were age ≥18 years with neurological symptoms, underwent brain MRI, and being diagnosed with CAH using DSA. The exclusion criteria were findings of other vascular pathologies including dissection and >50% intracranial vessel stenosis. Demographics of age, sex, body mass index (BMI), hypertension, diabetes, cardiac disorder, and previous stroke were analyzed among VAH, PCAH, and ACAH groups. Results: Of 769 subjects with clinical symptoms undergoing DSA, there were 66 (8.6%) cases of intracranial artery hypoplasia, including VAH (4.6%), PCAH (1.2%), and ACAH (2.9%). Subjects were predominantly old (53.2±10.1 years), male (53.0%), with BMI of 24.9±3.9 kg/m2 and hypertension (69.7%). Previous stroke (69.7%) was more prevalent than in previous study (28.1%). Stroke and brain ischemic lesion were detected in 89.4% and 84.8% cases. No differences were found in all parameters among all groups, but posterior circulation symptoms tended to be found in VAH (28.1%) than general stroke (20.3%). Conclusions: The high percentage of recurrent stroke and corresponding clinical symptoms associated with CAH supported that CAH may be a risk factor for clinical symptoms, including stroke, regardless of the involved artery.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%