The foramen magnum is an important landmark of the skull base and is of particular interest for anthropology, anatomy, forensic medicine, and other medical fields. Despite its importance, few osteometric studies of the foramen magnum have been published so far. A total of 110 transverse and 111 sagittal diameters from Central European male and female dry specimens dating from the Pleistocene to modern times were measured, and related to sex, age, stature, ethnicity, and a possible secular trend. Only a moderate positive correlation between the transverse and the sagittal diameter of the foramen magnum was found. Surprisingly, neither sexual dimorphism, individual age-dependency, nor a secular trend was found for either diameter. Furthermore, the relationship between the individual stature and foramen magnum diameters was weak: thus foramen magnum size cannot be used as reliable indicator for stature estimation. Further consideration of possible factors influencing the variability of human foramen magnum size shall be explored in larger and geographically more diverse samples, thus serving forensic, clinical, anatomical, and anthropological interests in this body part. Anat Rec, 292:1713Rec, 292: -1719Rec, 292: , 2009. V V C 2009 Wiley-Liss, Inc.Key words: anthropology; forensic medicine; osteometry; Pleistocene; secular trend; skull baseSpinal osteometry is a versatile and important method in many research fields including anthropology and basic medical sciences (Saillant, 1976;Krag et al., 1988;Schaeffer, 1999;Mitra et al., 2002;Ahern, 2005;Muthukumar et al., 2005). The foramen magnum, as a transition zone between spine and skull, plays an important role as a landmark because of its close relationship to key structures such as the brain and the spinal cord. There is a small heterogeneous group of anthropological and medical papers focusing on the foramen magnum: simple morphometric analysis of foramen magnum dimensions (Sendemir et al., 1994), foramen magnum size as a part of human occipital bone biometry (Olivier, 1975), its size relative to sex (Catalina-Herrera, 1987;Uysal et al., 2005), its relationship to the intra-cranial volume (Acer et al., 2006), its relationship to stature (Röthig, 1971), the use of the foramen magnum as an identification mark for fire victims (Holland, 1989), the inter-and intra-variability of the foramen magnum position in different species (Ahern, 2005), foramen magnum-carotid foramina relationship as a probable species diagnostic mark (Schaeffer, 1999), and the foramen magnum region in relation to surgical approaches (Muthukumar et al., 2005).Despite its anatomical and clinical relevance, there is still a lack of basic osteometric studies. Furthermore, to the best of our knowledge, no study has ever