Vertebral Brown Tumor in Childhood (Case Report)

Szeverényi, Csenge; Dezső, Balázs; Deményi, Tamás; Csernátony, Z.

doi:10.4236/ss.2011.26074

Cited by 7 publications

(4 citation statements)

References 12 publications

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“…Brown tumours (also known as osteitis fibrosa cystica) are associated with increased osteoclast activity that result from primary or secondary hyperparathyroidism. [1][2][3][4][5][6][7] There is a loss of the bone's trabeculae occurs as a consequence of increased osteoclast activity as well as a reactive proliferation of fibroblasts. The net result is bone of a predisposition to micro fractures and secondary haemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Brown tumour in the cervical spine : Case report and review of literature

Carta¹,

Chungh²,

Gowda

et al. 2019

CRCP

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Background: Brown tumour of the cervical spine is very rare and is formed due to focal altered bone remodelling secondary to persistent and uncontrolled primary or secondary hyperparathyroidism. It is considered an extreme form of osteitis fibrosa cystica that occurs in the settings of persistently elevated parathyroid hormone.Case Report: This a unique lesion presented in a 48 year old male with recurrent bone pain and known End Stage Renal Disease (ESRD) on maintenance haemodialysis. The main clinical complaints were weak and painful legs and the initial presentation was after the patient collapsed at home and fractured spinal level C2. The initial assessment included blood tests and radiological imaging. CT scanning of the spine revealed a destructive lytic lesion with loss of height and architectural changes of the C2 vertebral body and cord compression. The differentials included an acute fracture, a metastatic lesion and Brown’s tumour. Further imaging with an MRI of the spine and PET-CT were performed which confirmed the above lesion and excluded metastatic disease and bone marrow infiltration. A CT guided bone biopsy followed. The patient continued to receive medical treatment for secondary hyperparathyroidism and the C2 fracture was managed with orthosis through a protective hard collar.Discussion: An up to date literature review revealed very few cases of Brown tumour of the cervical spine and there was only one previous case with C2 involvement due to primary hyperparathyroidism and one due to secondary hyperparathyroidism. Clinicians must be aware of the varied presentations of Brown’s tumour to identify and provide the appropriate management.

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Section: Discussionmentioning

confidence: 99%

Brown tumour in the cervical spine : Case report and review of literature

Carta¹,

Chungh²,

Gowda

et al. 2019

CRCP

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“…(10) En pacientes con hiperparatiroidismo, el exceso de PTH resulta en una actividad osteoclástica incrementada y resorción ósea con fibrosis reactiva subsecuente. Los tumores pardos se producen a partir de la fusión de los quistes que se desarrollan durante la progresión de la resorción focal de la médula ósea y fibrosis (7,12) . En la tinción con hematoxilina eosina (H&E) estos tumores están compuestos de focos de hemosiderina y células gigantes tipo osteoclastos, dentro de un estroma fibrovascular consistente en fibroblastos densos en una matriz ricamente vascularizada (7) .…”

Section: Dra Natalí Leiva (Medicina Interna)unclassified

Caso clínico 01-2023. Varón de con debilidad en miembros inferiores, hipercalcemia y lesiones óseas

Zelaya,

Villena,

De la Cruz

et al. 2023

Rev Med Hered

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“… 1 6 7 The spinal involvement is rare, and occurrence in the cervical spine is exceedingly rare 4 6 with only a handful of cases previously reported in the literature. 6 7 8 9 10 11 12 13 14 Brown tumors involving the axis, the second cervical vertebra, are extremely unusual, and only two cases have been reported so far and both are in patients with primary HPT. 6 7 We report the third case of axis brown tumor as an initial manifestation of primary HPT.…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Primary Hyperparathyroidism Presenting as a C2 Brown Tumor-Plain Radiography Has yet again Proved Indispensable in Clinching the Diagnosis

Panwar

Bhat

Ballabh

et al. 2022

Indian J Radiol Imaging

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A brown tumor is one of the manifestations of hyperparathyroidism. It is a rare type of bone lesion that most often occurs in mandible, ribs, and large bones. Spinal involvement is extremely rare. We report an unusual case of a brown tumor of the axis vertebra in a 33-year-old male who presented to the orthopaedic clinic with posttraumatic C2 vertebra fracture and myelopathy. To plan further fixation and stabilization of C2 fracture, the patient underwent a plain radiograph and magnetic resonance imaging (MRI) of the cervical spine. The available routine chest radiograph at the time of MRI reporting clinched the diagnosis of primary hyperparathyroidism with a brown tumor of the axis vertebra. Thus, familiarity with subtle radiographic findings of this condition not only led to early diagnosis and appropriate treatment but also avoided unnecessary C2 biopsy and hardware fixation.

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Vertebral Brown Tumor in Childhood (Case Report)

Cited by 7 publications

References 12 publications

Brown tumour in the cervical spine : Case report and review of literature

Brown tumour in the cervical spine : Case report and review of literature

Caso clínico 01-2023. Varón de con debilidad en miembros inferiores, hipercalcemia y lesiones óseas

A Rare Case of Primary Hyperparathyroidism Presenting as a C2 Brown Tumor-Plain Radiography Has yet again Proved Indispensable in Clinching the Diagnosis

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