Vertebral Candidiasis, the State of the Art: A Systematic Literature Review

Candura, Dario; Perna, Andrea; Calori, Sara; Tamburrelli, Francesco Ciro; Proietti, Luca; Meluzio, Maria Concetta; Velluto, Calogero; Smakaj, Amarildo; Santagada, Domenico Alessandro

doi:10.1007/978-3-031-36084-8_36

Acta Neurochirurgica Supplement

2023

DOI: 10.1007/978-3-031-36084-8_36

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Vertebral Candidiasis, the State of the Art: A Systematic Literature Review

Dario Candura,

Andrea Perna,

Sara Calori

et al.

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2024

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The IFSD Score—A Practical Prognostic Model for Invasive Fungal Spondylodiscitis

Yang,

Lee,

Liu

et al. 2024

JoF

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Objectives: Invasive fungal spondylodiscitis (IFSD) is rare and could be lethal in certain circumstances. The previous literature revealed limited data concerning its outcomes. This study aimed to establish a risk-scoring system to predict the one-year mortality rate of this disease. Methods: A total of 53 patients from a multi-centered database in Taiwan were included in this study. All the clinicopathological and laboratory data were retrospectively analyzed. Variables strongly related to one-year mortality were identified using a multivariate Cox proportional hazards model. A receiver operating characteristic (ROC) curve was used to express the performance of our IFSD scoring model. Results: Five strong predictors were included in the IFSD score: predisposing immunocompromised state, the initial presentation of either radiculopathy or myelopathy, initial laboratory findings of WBC > 12.0 or <0.4 103/µL, hemoglobin < 8 g/dL, and evidence of candidemia. One-year mortality rates for patients with IFSD scores of 0, 1, 2, 3, and 4 were 0%, 16.7%, 56.3%, 72.7%, and 100%, respectively. The area under the curve of the ROC curve was 0.823. Conclusions: We developed a practical scoring model with easily obtained demographic, clinical, and laboratory parameters to predict the probability of one-year mortality in patients with IFSD. However, more large-scale and international validations would be necessary before this scoring model is commonly used.

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The IFSD Score—A Practical Prognostic Model for Invasive Fungal Spondylodiscitis

Yang,

Lee,

Liu

et al. 2024

JoF

View full text Add to dashboard Cite

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Vertebral Candidiasis, the State of the Art: A Systematic Literature Review

Cited by 1 publication

References 92 publications

The IFSD Score—A Practical Prognostic Model for Invasive Fungal Spondylodiscitis

The IFSD Score—A Practical Prognostic Model for Invasive Fungal Spondylodiscitis

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