Vertebral Compression Fracture Treatment with Vertebroplasty and Kyphoplasty: Experience in 407 Patients with 1,156 Fractures in a Tertiary Cancer Center

Burton, Allen W.; Mendoza, Tito R.; Gebhardt, Rodolfo; Hamid, Basem; Nouri, Kent H.; Perez-Toro, Marco R.; Ting, Joseph; Koyyalagunta, Dhanalakshmi

doi:10.1111/j.1526-4637.2011.01278.x

Cited by 51 publications

(29 citation statements)

References 36 publications

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“…New fractures occurring after vertebroplasty may partly be due to the underlying disease, but some studies have reported a larger amount of new fractures next to the vertebrae treated with PMMA. [19][20][21] The maximum filling approach, in which as much cement as possible is injected into the vertebra, has been suggested to have a particularly detrimental effect. 22,23 .…”

Section: Introductionmentioning

confidence: 99%

The effect of unsaturated fatty acid and triglyceride oil addition on the mechanical and antibacterial properties of acrylic bone cements

et al. 2015

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Acrylic bone cements have an elastic modulus several times higher than the surrounding trabecular bone. This has been hypothesized to contribute to certain clinical complications. There are indications that the addition of specific fatty acids and triglyceride oils may reduce the elastic modulus of these types of cements. Some of these additives also appear to have inherent antibiotic properties, although this has never been evaluated in bone cements. In this study, several types of fatty acids and triglyceride oils were evaluated for use in acrylic bone cements. Their mechanical properties were evaluated under uniaxial compression testing and selected cements were then further characterized in terms of microstructure, handling and antibacterial properties using scanning electron microscopy, polymerization temperature measurements, agar diffusion tests and bactericidal activity assays of cement extracts.It was found that any of the evaluated fatty acids or triglyceride oils could be used to tailor the stiffness of acrylic bone cements, although at varying concentrations, which also depended on the type of commercial base cement used. In particular, the addition 2 of very small amounts of linoleic acid (<2.0 wt%) resulted in Young's moduli and compressive strengths in the range of human trabecular bone, while maintaining a similar setting time. Further, the addition of 12.6 wt% ricinoleic acid to Osteopal V cement was found to have a significant antibacterial effect, inhibiting growth of Staphylococcus aureus in an agar diffusion test as well as demonstrating 100% bactericidal activity against the same strain.

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Section: Introductionmentioning

confidence: 99%

The effect of unsaturated fatty acid and triglyceride oil addition on the mechanical and antibacterial properties of acrylic bone cements

et al. 2015

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“…There is further evidence to support the safety and efficacy of percutaneous cement augmentation even in the setting of pathologic compression fractures [7][8][9][10][11]. In one large series of over 1150 treated fractures, these procedures provided significant relief from pain and related symptoms [8]. Serious complications occurred in less than 0.01% of cases.…”

Section: Management Of Vcfmentioning

confidence: 98%

“…There is a substantial body of evidence that supports the use of percutaneous cement augmentation, including vertebroplasty and balloon kyphoplasty, in the setting of osteoporotic compression fractures [6]. There is further evidence to support the safety and efficacy of percutaneous cement augmentation even in the setting of pathologic compression fractures [7][8][9][10][11]. In one large series of over 1150 treated fractures, these procedures provided significant relief from pain and related symptoms [8].…”

Section: Management Of Vcfmentioning

confidence: 99%

Other complications associated with spinal stereotactic body radiation therapy

Sahgal

Teh

et al. 2014

Stereotactic Body Radiation Therapy: Spinal Metastasis

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“…It must be taken into consideration here that the increase in vertebral body height by the Osseofix ® system is minor compared to that of kyphoplasty. Lin et al [30] found a significantly higher risk for vertebral refractures after vertebroplasty as a function of the increase in vertebral body height. The average Cobb angle (γ-angle) improved significantly from a preoperative angle of 12.3°to 10.8°after 12 months.…”

Section: Special Complicationsmentioning

confidence: 99%

“…The literature provides only sparse information about a secondary loss of height resulting in a certain recurrence of kyphosis [29]. Rates of 0 % to 63 % [30,31] for vertebroplasty and 14 -50 % for kyphoplasty are described [32,33] (follow-up period of 6 -27 months). Our rate of a secondary loss of height of 3.1 % is low.…”

Section: Special Complicationsmentioning

confidence: 99%

Osseofix® System for Percutaneous Stabilization of Osteoporotic and Tumorous Vertebral Compression Fractures – Clinical and Radiological Results After 12 Months

Ender

Gradl²,

Ender

et al. 2013

Fortschr Röntgenstr

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Purpose: Determining whether implantation of an expandable titanium mesh cage (Osseofix? system) is a successful and safe minimally invasive therapy for osteoporotic and tumorous vertebral compression fractures (VCFs). Materials and Methods: 32 patients (25 women, 7 men, mean age 71) with 46 osteoporotic or tumorous VCFs (T6 to L4) from June 2010 to January 2012 were included. All of them were stabilized with the Osseofix? system. Preinterventionally we performed X-ray, MRI, and bone density measurements (DXA). The clinical and radiological results were evaluated preop, postop and 12 months postop based on the visual analog scale (VAS) and the Oswestry Disability Index (ODI), X-ray (Beck Index, Cobb angle) and CT. Results: There was a significant improvement in pain intensity (VAS) (7.8 to 1.6) as well as a?significant reduction in the mean ODI (71.36?% to 30.4?%) after 12 months. The mean kyphotic angle according to Cobb showed significant improvements (12.3? to 10.8?) after 12 months. Postinterventional imaging showed one case of loss of height in a stabilized lumbar vertebral body (2.2?%) in osteoporosis and one case with adjacent fracture (2.2?%) in osteoporosis. We saw no changes in the posterior vertebral wall. Except for one pronounced postoperative hematoma, we saw no surgical complications including no cement leakage. Conclusion: The clinical mid-term results are good at a low complication rate. The stabilization of symptomatic osteoporotic and tumorous VCFs with the Osseofix? system is a safe and effective procedure, even in fractures with posterior wall involvement. The Osseofix? system is an interesting alternative to the established procedures of cement augmentation. Key Points: ??The Osseofix? system is well suited for stabilizing osteoporotic and tumorous VCFs. ??It is a safe and effective procedure without cement leakage and with a low complication rate. ??The procedure is an interesting alternative to established cement augmentation procedures. Citation Format: ??Ender SA, Gradl G, Ender M et?al. Osseofix? System for Percutaneous Stabilization of Osteoporotic and Tumorous Vertebral Compression Fractures ? Clinical and Radiological Results After 12 Months. Fortschr R?ntgenstr 2014; 186: 380???387

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Vertebral Compression Fracture Treatment with Vertebroplasty and Kyphoplasty: Experience in 407 Patients with 1,156 Fractures in a Tertiary Cancer Center

Abstract: Our single-center experience revealed that a large number of cancer patients suffer from painful VCFs. The use of VP or KP in treating painful VCFs in cancer patients has good efficacy and an acceptably low complication rate.

Cited by 51 publications

References 36 publications

The effect of unsaturated fatty acid and triglyceride oil addition on the mechanical and antibacterial properties of acrylic bone cements

The effect of unsaturated fatty acid and triglyceride oil addition on the mechanical and antibacterial properties of acrylic bone cements

Other complications associated with spinal stereotactic body radiation therapy

Osseofix® System for Percutaneous Stabilization of Osteoporotic and Tumorous Vertebral Compression Fractures – Clinical and Radiological Results After 12 Months

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