Vertebral Damage to Bluegills Exposed to Acutely Toxic Levels of Pesticides

McCann, John A.; Jasper, R. L.

doi:10.1577/1548-8659(1972)101<317:vdtbet>2.0.co;2

Cited by 35 publications

(15 citation statements)

References 2 publications

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“…Vertebral anomalies such as kyphosis, lordosis or scoliosis of unknown etiologies have been reported in natural populations of fresh water and marine fish (Bengtsson 1975a;Moore & Hixson 1977). Other investigators have reported vertebral abnormalities, especially scoliosis, occurring in several species of fish as a result of parasitic infections (Hoffman 1962), dietary deficiencies (Halver 1972;Horak 1975), heavy metal exposure (Bengtsson 1975b;Holcombe, Benoit, Leonard & McKim 1976), organochlorine (Meyer 1966;McCann & Jasper The present report describes heretofore undescribed vertebral tissue response of sheepshead minnows during early life and adult exposure to trifluralin. To our knowledge, no pathological response identical to the subsequently described effects has been reported for any animal experimentally exposed to chemicals.…”

Section: Introductionmentioning

confidence: 56%

Vertebral dysplasia in young fish exposed to the herbicide trifluralin

Couch

Winstead

Hansen

et al. 1979

Journal of Fish Diseases

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Sheepshead minnows, Cyprinodon variegatus Laeepede, exposed to 5 5 to 31 /xg/1 of the herbicide trifluralin, throughout their first 28 days of life, developed a heretofore undescribed vertebral dysplasia. This dysplasia consisted of semisymmetrical hypertrophy of vertebrae (three to 20 times normal), characterized by foci of osteoblast and fibroblasts actively laying down bone and bone precursors. Effects of the abnormal vertebral development were dorsal vertebral growth into the neural canal, ventral compression of renal ducts, and longitudinal fusion of vertebrae. Fish, exposed for 51 days to 16-6 /ng/1 trifluralin and thereafter depurated for 41 days, showed no increase in vertebral dysplasia during depuration; however, residual spinal column damage was evident. Serum calcium concentrations were elevated in adult fish exposed for 4 days to 16-6 /xg/1 trifluralin. Fluorosis or mimicry of hypervitaminosis A are considered possible mechanisms for the osseous effect, but are not considered to be the only possible causes. The highly predictable nature of this disorder in experimental exposures strengthens the probability that young flsh may serve as experimental models for determining effects of chemicals on early vertebrate ontogeny, particularly in regard to skeletal development.

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Section: Introductionmentioning

confidence: 56%

Vertebral dysplasia in young fish exposed to the herbicide trifluralin

Couch

Winstead

Hansen

et al. 1979

Journal of Fish Diseases

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“…The strong localization of vertebral damage in the posterior backbone area is indicative of the second category of vertebral damage: acute muscular contraction (Spencer, 1967;McCann & Jasper, 1972). Although such contractions may result from electrical shock, we rule out electrofishing as the cause of the deformities in crappies from Lake Decatur.…”

Section: Discussionmentioning

confidence: 97%

Vertebral abnormalities in white crappies, Pomoxis annularis Rafinesque, from Lake Decatur, Illinois, and an investigation of possible causes

Baumann

Hamilton

1984

Journal of Fish Biology

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Crappie, Pornoxis unnnuluris, from Lake Decatur, Illinois, were reported to have a high incidence of backbone deformities, an investigation was initiated to determine both the mechanism of vertebral injury and the causative agent. Three groups of fish were collected normally shaped and abnormally shaped crappies from Lake Decatur and control fish from abnormally shaped crappies from Lake Decatur and control fish from nearby Lake Sangchris. Analysis of organic and inorganic residue levels in fish tissue revealed no significant levels of contaminants in any of the three groups. Evaluation of the mechanical properties, biochemical composition, and density characteristic of vertebral bone showed no significant difference between the three groups. A myxosporidean parasite, found in both normal and abnormally shaped crappies from Lake Decatur, may have been a contributing factor leading to the spinal deformities. We believe that a short-term exposure to organophosphate insecticides, may have occurred causing muscular contractions and resulting in vertebral damage and abnormally shaped fish.

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“…Although the mechanism for expression is unknown, the abnormalities were attributed to toxicant interference with normal developmental processes, rather than tetany or severe neuromuscular contractions. Sporadic or chronic rigor in skeletal musculature has been proposed as the apparent mechanism for vertebral fractures in studies with older fish exposed to kepone (Couch et al 1977) or organophosphate pesticides (McCann & Jasper 1972, Kumar & Ansari 1984.…”

Section: Discussionmentioning

confidence: 99%

Vertebral abnormalities in juvenile inland silversides Menidia beryllina exposed to terbufos during embryogenesis

Middaugh¹,

Fournie²,

Hemmer³

1990

Dis. Aquat. Org.

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Embryos of the inland silverside Menidia beryllina were exposed to a nominal concentration of 50 pg terbufos I-' during the first 5 d of embryogenesis. Silversides were maintained in clean dilute seawater until 37 d after hatching. Radiographs revealed compressed and fused vertebrae and dorsal-ventral misalignment of pre-and post-zygapophyseal processes. Histopathological examination of representative individuals exposed to terbufos during embryogenesis revealed various vertebral lesions ranging from small hyperostoses to almost complete fusion of some vertebrae.

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Vertebral Damage to Bluegills Exposed to Acutely Toxic Levels of Pesticides

Cited by 35 publications

References 2 publications

Vertebral dysplasia in young fish exposed to the herbicide trifluralin

Vertebral dysplasia in young fish exposed to the herbicide trifluralin

Vertebral abnormalities in white crappies, Pomoxis annularis Rafinesque, from Lake Decatur, Illinois, and an investigation of possible causes

Vertebral abnormalities in juvenile inland silversides Menidia beryllina exposed to terbufos during embryogenesis

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