Vertebral fractures in patients with chronic obstructive pulmonary disease: the EOLO Study

Nuti, Ranuccio; Siviero, Paola; Maggi, Stefania; Guglielmi, Giuseppe; Caffarelli, Carla; Crepaldi, Gaetano; Gonnelli, Stefano

doi:10.1007/s00198-008-0770-4

Cited by 101 publications

(92 citation statements)

References 41 publications

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“….One plausible explanation for the relatively young menopausal age of some of the study subjects is the effect of smoking itself in reducing sex steroids. (55) In additional to more years since menopause, the group with COPD who fractured had lower BMIs, a finding reported previously, (10) and lower levels of 25(OH)D when compared with the group that did not fracture. These findings suggest that besides the pulmonary disease, COPD patients experience other risk factors for fracture, and probably each of these contributes to a decrease in bone strength.…”

Section: Discussionsupporting

confidence: 49%

“…Fifty-four subjects were excluded because of the following: oral glucocorticoid use > 3 months (20), other secondary causes of osteoporosis (12), declined to participate (8), nonsmoking COPD (3), age > 75 years (10), and allergy to tetracycline (1). The remaining 39 COPD patients were selected to have BMD and blood tests.…”

Section: Resultsmentioning

confidence: 99%

“…(5,34,35) Not unexpectedly, therefore, there is a high prevalence of vertebral fracture in COPD, as shown by lateral vertebral X-rays in those without a history of glucocorticoid exposure. (10) This study supplies new information that provides insight into the microstructural bases for these observations. In agreement with two independent analytical techniques (histomorphometry and mCT), we demonstrated that in postmenopausal women with COPD, bone volume is low, and microarchitectural deterioration is evident by low trabecular connectivity, trabecular number, and thickness and an increase in trabecular spacing.…”

Section: Discussionmentioning

confidence: 99%

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Skeletal microstructural abnormalities in postmenopausal women with chronic obstructive pulmonary disease

Kulak

Borba

Jorgetti

et al. 2010

Journal of Bone and Mineral Research

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Chronic obstructive pulmonary disease (COPD) is associated with osteoporosis and fragility fractures. The objectives of this study were to assess static and dynamic indices of cancellous and cortical bone structure in postmenopausal women with COPD. Twenty women with COPD who had not received chronic oral glucocorticoids underwent bone biopsies after double tetracycline labeling. Biopsies were analyzed by histomorphometry and mCT and compared with age-matched controls. Distribution of the patients according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) was: Type I (15%), Type II (40%), Type III (30%), and Type IV (15% . This is the first evaluation of bone microstructure and remodeling in COPD. The skeletal abnormalities seen in cancellous and cortical bone provide an explanation for the high prevalence of vertebral fractures in this disease. ß

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Section: Discussionsupporting

confidence: 49%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Skeletal microstructural abnormalities in postmenopausal women with chronic obstructive pulmonary disease

Kulak

Borba

Jorgetti

et al. 2010

Journal of Bone and Mineral Research

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“…Nuti et al 21 reported that COPD duration was 1 year in 13.1%, 1-5 years in 31.2% and above 5 years in 55.8% of patients.…”

Section: Discussionmentioning

confidence: 99%

“…All the collected data were compiled and analyzed using the SPSS (Statistical package for social science) 21 In this study bone mineral density was normal in 6 (10.0%), osteopenia in 24 (40.0%) and osteoporosis in 30 (50%) patients as regards BMD in femoral neck; while normal bone mineral density was in 4 (6.7%), osteopenia in 17 (28.3%) and osteoporosis in 39 (65.0%) patients as regards BMD in lumbar spine. Also it was demonstrated that 90% of patients with COPD varying from moderate to very severe had abnormal BMD in femoral neck and about 93% of patients with COPD varying from moderate to very severe had abnormal BMD in lumbar spine.…”

Section: Methodsmentioning

confidence: 99%

Prevalence of Osteoporosis in Male Patients with Chronic Obstructive Pulmonary Disease

Bari

Patwary²,

Hossain

et al. 2018

Med. Today

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Bone stiffness and failure load are related with clinical parameters in men with chronic obstructive pulmonary disease

Romme

Rutten

Geusens

et al. 2013

Journal of Bone and Mineral Research

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Osteoporosis is frequently seen in patients with chronic obstructive pulmonary disease (COPD). Because research on bone structure and bone strength in COPD patients is limited, the objectives of this pilot study were as follows: (1) to compare bone structure, stiffness, and failure load, measured at the peripheral skeleton, between men with and without COPD after stratification for areal bone mineral density (aBMD); and (2) to relate clinical parameters with bone stiffness and failure load in men with COPD. We included 30 men with COPD (normal aBMD, n ¼ 18; osteoporosis, n ¼ 12) and 17 men without COPD (normal aBMD, n ¼ 9; osteoporosis, n ¼ 8). We assessed packyears of smoking, body mass index (BMI), fat free mass index (FFMI), pulmonary function (forced expiratory volume in 1 second [FEV 1 ], FEV 1 /forced vital capacity [FVC], diffusion capacity for carbon monoxide [DLCO], and transfer coefficient for carbon monoxide [KCO]), and extent of emphysema. Bone structure of the distal radius and tibia was assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT), and bone stiffness and failure load of the distal radius and tibia were estimated from micro finite element analysis (mFEA). After stratification for aBMD and COPD, men with osteoporosis showed abnormal bone structure (p < 0.01), lower bone stiffness (p < 0.01), and lower failure load (p < 0.01) compared with men with normal aBMD, and men with COPD had comparable bone structure, stiffness, and failure load compared with men without COPD. In men with COPD, lower FFMI was related with lower bone stiffness, and failure load of the radius and tibia and lower DLCO and KCO were related with lower bone stiffness and failure load of the tibia after normalization with respect to femoral neck aBMD. Thus, this pilot study could not detect differences in bone structure, stiffness, and failure load between men with and without COPD after stratification for aBMD. FFMI and gas transfer capacity of the lung were significantly related with bone stiffness and failure load in men with COPD after normalization with respect to femoral neck aBMD.

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Vertebral fractures in patients with chronic obstructive pulmonary disease: the EOLO Study

Abstract: In COPD patients the risk of vertebral fractures is strictly related to the severity of the disease. The use of glucocorticoids and reduced QUS at calcaneous may represent additional risk factors.

Cited by 101 publications

References 41 publications

Skeletal microstructural abnormalities in postmenopausal women with chronic obstructive pulmonary disease

Skeletal microstructural abnormalities in postmenopausal women with chronic obstructive pulmonary disease

Prevalence of Osteoporosis in Male Patients with Chronic Obstructive Pulmonary Disease

Bone stiffness and failure load are related with clinical parameters in men with chronic obstructive pulmonary disease

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