Vertebral fragility and structural redundancy

Fields, Aaron J.; Nawathe, Shashank; Eswaran, Senthil Kumar; Jekir, Michael; Adams, Mark F.; Papadopoulos, Panayiotis; Keaveny, Tony M.

doi:10.1002/jbmr.1664

Cited by 40 publications

(31 citation statements)

References 59 publications

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“…Results of the FE analysis revealed that also the stresses and strains during compression were in the midrange of values found throughout the vertebra while the model did not predict fracture for this element in most cases. This is in agreement with results of micro-FE analyses recently presented by others which also suggest that failure does not accumulate at the vertebral center but rather near the endplates [35]. Taken together, these results indicate that the particular location at the center of vertebra may be a good predictor mainly because of the consistent correlation between BV/TV and bone strength, and not because it is the weakest link during loading.…”

Section: Discussionsupporting

confidence: 92%

Locally measured microstructural parameters are better associated with vertebral strength than whole bone density

et al. 2013

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Locally measured microstructural parameters are better associated with vertebral strength than whole bone densityHazrati Marangalou, J.; Eckstein, F.; Kuhn, V.; Ito, K.; Cataldi, M.; Taddei, F.; van Rietbergen, B. Published in: Osteoporosis International DOI:10.1007/s00198-013-2591-3Published: 01/01/2014 Document VersionAccepted manuscript including changes made at the peer-review stage Please check the document version of this publication:• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication Citation for published version (APA):Hazrati Marangalou, J., Eckstein, F., Kuhn, V., Ito, K., Cataldi, M., Taddei, F., & Rietbergen, van, B. (2014). Locally measured microstructural parameters are better associated with vertebral strength than whole bone density. Osteoporosis International, 25(4), 1285 -1296 . DOI: 10.1007 /s00198-013-2591 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Abstract Summary Whole vertebrae areal and volumetric bone mineral density (BMD) measurements are not ideal predictors of vertebral fractures. We introduce a technique which enables quantification of bone microstructural parameters at precisely defined anatomical locations. Results show that local assessment of bone volume fraction at the optimal location can substantially improve the prediction of vertebral strength. Introduction Whole vertebrae areal and volumetric BMD measurements are not ideal predictors of vertebral osteoporotic fractures. Recent studies have shown that sampling bone microstructural parameters in smaller regions may permit better predictions. In such studies, however, the sampling location is described only in general anatomical terms. Here, we introduce a technique that enables the quantification of bone volume fraction and microstructural paramet...

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Section: Discussionsupporting

confidence: 92%

Locally measured microstructural parameters are better associated with vertebral strength than whole bone density

et al. 2013

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“…The apparent elastic moduli in the longitudinal direction (Ef) and the transverse directions (E2, £), E2>Ei) were computed and three mechanical anisotropy ratios (EfiEx, E3/E2, E qJ E i ) were defined for each specimen. This material model has been used in various previous studies [27][28][29] and was directly validated against experiments for uniaxial strength behavior (R2 = 0.96, Y = X type of agreement, n = 22 specimens of human bone) [27], To describe the complete multiaxial failure behavior for each specimen, a series of nonlinear finite element simulations was per formed, spanning the 6D multiaxial yield surface. A trans versely isotropic material property set for each specimen was defined by assigning equal moduli in the two transverse direc tions.…”

Section: Methodsmentioning

confidence: 99%

“…A trans versely isotropic material property set for each specimen was defined by assigning equal moduli in the two transverse direc tions. All finite element analyses were per formed using a highly scalable parallel finite element framework, Olympus as described in the previous studies [27][28][29]. For all specimens, all elements in each finite element model were assigned the same isotropic material properties for the solid bone tissue.…”

Section: Methodsmentioning

confidence: 99%

The Quartic Piecewise-Linear Criterion for the Multiaxial Yield Behavior of Human Trabecular Bone

Sanyal

Scheffelin

Keaveny

2015

Journal of Biomechanical Engineering

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Prior multiaxial strength studies on trabecular bone have either not addressed large variations in bone volume fraction and microarchitecture, or have not addressed the full range of multiaxial stress states. Addressing these limitations, we utilized micro-computed tomography (lCT) based nonlinear finite element analysis to investigate the complete 3D multiaxial failure behavior of ten specimens (5mm cube) of human trabecular bone, taken from three anatomic sites and spanning a wide range of bone volume fraction (0.09–0.36),mechanical anisotropy (range of E3/E1¼3.0–12.0), and microarchitecture. We found that most of the observed variation in multiaxial strength behavior could be accounted for by normalizing the multiaxial strength by specimen-specific values of uniaxial strength (tension,compression in the longitudinal and transverse directions). Scatter between specimens was reduced further when the normalized multiaxial strength was described in strain space.The resulting multiaxial failure envelope in this normalized-strain space had a rectangular boxlike shape for normal–normal loading and either a rhomboidal box like shape or a triangular shape for normal-shear loading, depending on the loading direction. The finite element data were well described by a single quartic yield criterion in the 6D normalized strain space combined with a piecewise linear yield criterion in two planes for normalshear loading (mean error SD: 4.660.8% for the finite element data versus the criterion).This multiaxial yield criterion in normalized-strain space can be used to describe the complete 3D multiaxial failure behavior of human trabecular bone across a wide range of bone volume fraction, mechanical anisotropy, and microarchitecture.

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“…Recently, a 3D approach was introduced to segment a trabecular network into vertical and horizontal trabeculae of the vertebral body [37][38][39] . Fields et al [37,38] found that vertical trabeculae played a particular important role for the compressive bone strength of vertebrae with low BMD and presumed that vertebral bone strength is better explained by the vertical trabecular bone volume fraction alone, than by the total trabecular bone volume fraction. The scanning electron microscopic images confirmed that the horizontal trabeculae were thinner, whereas the vertical ones were relatively thicker ( Figure 3B).…”

Section: Vertebramentioning

confidence: 99%

Bone three-dimensional microstructural features of the common osteoporotic fracture sites

Chen

Kubo

2014

WJO

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Osteoporosis is a common metabolic skeletal disorder characterized by decreased bone mass and deteriorated bone structure, leading to increased susceptibility to fractures. With aging population, osteoporotic fractures are of global health and socioeconomic importance. The three-dimensional microstructural information of the common osteoporosis-related fracture sites, including vertebra, femoral neck and distal radius, is a key for fully understanding osteoporosis pathogenesis and predicting the fracture risk. Low vertebral bone mineral density (BMD) is correlated with increased fracture of the spine. Vertebral BMD decreases from cervical to lumbar spine, with the lowest BMD at the third lumbar vertebra. Trabecular bone mass of the vertebrae is much lower than that of the peripheral bone. Cancellous bone of the vertebral body has a complex heterogeneous three-dimensional microstructure, with lower bone volume in the central and anterior superior regions. Trabecular bone quality is a key element to maintain the vertebral strength. The increased fragility of osteoporotic femoral neck is attributed to low cancellous bone volume and high compact porosity. Compared with age-matched controls, increased cortical porosity is observed at the femoral neck in osteoporotic fracture patients. Distal radius demonstrates spatial inhomogeneous characteristic in cortical microstructure. The medial region of the distal radius displays the highest cortical porosity compared with the lateral, anterior and posterior regions. Bone strength of the distal radius is mainly determined by cortical porosity, which deteriorates with advancing age. Key words: Osteoporosis; Fracture; Microstructure; Trabecular bone; Cortical bone; Vertebra; Femoral neck; Distal radius Core tip: The most common sites of the osteoporotic fractures include the vertebra, femoral neck and distal radius, where the microstructural information is a key for fully understanding osteoporosis pathogenesis and improving the prediction of fracture risk. Vertebral strength is mostly preserved by trabecular bone, which is microstructurally inhomogeneous, with lower bone volume in the central and anterior superior regions. Increased fragility of osteoporotic femoral neck is attributed to low cancellous bone volume and high compact porosity. Distal radius shows significant variations in cortical porosity, which is the major element attributed to bone strength of the distal radius.

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Vertebral fragility and structural redundancy

Cited by 40 publications

References 59 publications

Locally measured microstructural parameters are better associated with vertebral strength than whole bone density

Locally measured microstructural parameters are better associated with vertebral strength than whole bone density

The Quartic Piecewise-Linear Criterion for the Multiaxial Yield Behavior of Human Trabecular Bone

Bone three-dimensional microstructural features of the common osteoporotic fracture sites

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