Vertebral strength prediction from Bi-Planar dual energy x-ray absorptiometry under anterior compressive force using a finite element model: An in vitro study

Abstract

Finite element models (FEM) derived from qCT-scans were developed as a clinical tool to evaluate vertebral strength. However, the high dose, time and cost of qCT-scanner are limitations for routine osteoporotic diagnosis. A new approach considers using bi-planar dual energy (BP2E) X-rays absorptiometry to build vertebral FEM using synchronized sagittal and frontal plane radiographs. The purpose of this study was to compare the performance of the areal bone mineral density (aBMD) measured from DXA, qCT-based FEM and BP2E-based FEM in predicting experimental vertebral strength. Twenty eight vertebrae from eleven lumbar spine segments were imaged with qCT, DXA and BP2E X-rays before destructively tested in anterior compression. FEM were built based on qCT and BP2E images for each vertebra. Subject-specific FEM were built based on 1) the BP2E images using 3D reconstruction and volumetric BMD distribution estimation and 2) the qCT scans using slice by slice segmentation and voxel based calibration. Linear regression analysis was performed to find the best predictor for experimental vertebral strength (F); aBMD, modeled vertebral strength and vertebral stiffness. Areal BMD was moderately correlated with F (R = 0.74). FEM calculations of vertebral strength were highly to strongly correlated with F (R = 0.84, p < 0.001 for BP2E model and R = 0.95, p < 0.001 for qCT model). The results of this study suggest that aBMD accounted for only 74% of F variability while FE models accounted for at least 84%. For anterior compressive loading on isolated vertebral bodies, simplistic loading condition aimed to replicate anterior wedge fractures, both FEM were good predictors of F. Therefore FEM based on BP2E X-rays absorptiometry could be a good alternative to replace qCT-based models in the prediction of vertebral strength. However future work should investigate the performance of the BP2E-based model in vivo in discriminating patients with and without vertebral fracture in a prospective study.

Bone strain index reproducibility and soft tissue thickness influence: a dual x-ray photon absorptiometry phantom study

“…This software applies a mathematical model called finite element method (FEM) to DXA lumbar spine scans. FEM derived from quantitative computed tomography scans demonstrated to be predictive of experimental vertebra strength [11]. The BSI parameter uses the format of digital imaging and communications in medicine (DICOM) files to obtain an average strain field from FEM analysis, calculated within each lumbar vertebra.…”

Fracture Risk Evaluation of Bone Metastases: A Burning Issue

“…To overcome SINS limitations, FE models are also in development to evaluate the strength of vertebrae [105][106][107]. Only a few studies have presented experimentallyvalidated FE models for strength assessment of vertebrae with defects [104,108], and several issues remain to be addressed.…”

“…This is an important challenge for the coming years to guide patients in their rehabilitation once cancer stabilization is obtained. The EOS system, in comparison to standard radiographs, presents the advantages of low radiation, high-quality image [125], and potentiality to build a patient-specific FE model to predict bone strength [105,126]. In the case of a vertebra without metastasis, a sensitivity study has previously shown that a 1-cm anterior displacement of the loading on a vertebra would approximately decrease the vertebral strength by 50%.…”

Beyond bone mineral density: new developments in dual X-ray absorptiometry assessment of bone quality

“…Furthermore, it is important to apply this method to both the femoral and the lumbar anatomical sites usually scanned using DXA. Nevertheless, recent studies have demonstrated that FEMs are better experimental vertebral strength predictors than areal BMD measured with DXA [24] .…”