Vertebral Tortuosity Index in Patients with Non-Connective Tissue Disorder-Related Aneurysm Disease

Virgilio, Francesca; Maurel, Blandine; Davis, Meryl; Hamilton, George; Mastracci, Tara M.

doi:10.1016/j.ejvs.2016.11.026

Cited by 14 publications

(9 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was shown before for aortic [10] and splenic artery [11] aneurysms. In terms of other cerebral vessels, a similar association was found for ICA [14,23], MCA [12], ACoA [13] and VA [24]. Additionally, increased tortuosity was associated with lower risk of intracranial aneurysm rupture [25] and inversely correlated with its size [13].…”

Section: Discussionsupporting

confidence: 60%

Increased tortuosity of basilar artery might be associated with higher risk of aneurysm development

et al. 2020

View full text Add to dashboard Cite

Objectives We analysed tortuosity of basilar artery (BA) to determine its relationship with the presence of aneurysm. Methods We retrospectively analysed 71 patients with BA aneurysms along with 71 age- and risk factors-matched control patients without BA aneurysm. From patients’ medical records, we obtained their history including previous and current diseases and medications. For each patient, we calculated relative length (RL), sum of angle metrics (SOAM), triangular index (TI), product of angle distance (PAD) and inflexion count metrics (ICM). We used t-test and Mann-Whitney U test for continuous variables and χ2 test for dichotomised variables. To find independent predictors of BA aneurysm, we employed logistic regression analysis. Results We found significant positive correlation between age and SOAM (R = 0.195, p = 0.02) and PAD (R = 0.199, p = 0.018). Our study also showed that patients with BA aneurysm had significantly higher SOAM (0.21 ± 0.16 vs. 0.11 ± 0.08; p < 0.01), PAD (0.30 ± 0.19 vs. 0.18 ± 0.11; p < 0.01), TI (0.23 ± 0.23 vs. 0.10 ± 0.16; p < 0.01) and ICM (0.20 ± 0.16 vs. 0.15 ± 0.11; p = 0.045). In multivariate logistic regression analysis, after adjustment for all possible confounders, SOAM (OR = 1.086; 95% CI 1.046–1.136; p < 0.01) and TI (OR = 1.004; 95%C: 1.002–1.006; p < 0.01) remained independently associated with higher risk of BA aneurysm. Conclusions Increased tortuosity of BA is associated with higher risk of its aneurysm development. Key Points • Basilar artery sum of angle metrics and product of angle distance are correlated with age. • Basilar artery tortuosity is independently associated with higher risk of its aneurysm development. • Basilar artery tortuosity is positively correlated with its diameter and bifurcation angle.

show abstract

Section: Discussionsupporting

confidence: 60%

Increased tortuosity of basilar artery might be associated with higher risk of aneurysm development

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Therefore, to the best of our knowledge, this is the first report on the correlation between VA tortuosity and IA formation. 24 Compared with the control group, the IA group had a higher TI in the posterior circulation, such as in the BA and both VAs. The posterior circulation is more vulnerable to hemodynamic stress and pathologic changes such as blood pressure and dolichoectasia respectively.…”

Section: Discussionmentioning

confidence: 88%

How Cerebral Vessel Tortuosity Affects Development and Recurrence of Aneurysm: Outer Curvature versus Bifurcation Type

et al. 2021

View full text Add to dashboard Cite

Background and Purpose Previous studies have assessed the relationship between cerebral vessel tortuosity and intracranial aneurysm (IA) based on two-dimensional brain image analysis. We evaluated the relationship between cerebral vessel tortuosity and IA according to the hemodynamic location using three-dimensional (3D) analysis and studied the effect of tortuosity on the recurrence of treated IA.Methods We collected clinical and imaging data from patients with IA and disease-free controls. IAs were categorized into outer curvature and bifurcation types. Computerized analysis of the images provided information on the length of the arterial segment and tortuosity of the cerebral arteries in 3D space.Results Data from 95 patients with IA and 95 controls were analyzed. Regarding parent vessel tortuosity index (TI; P<0.01), average TI (P<0.01), basilar artery (BA; P=0.02), left posterior cerebral artery (P=0.03), both vertebral arteries (VAs; P<0.01), and right internal carotid artery (P<0.01), there was a significant difference only in the outer curvature type compared with the control group. The outer curvature type was analyzed, and the occurrence of an IA was associated with increased TI of the parent vessel, average, BA, right middle cerebral artery, and both VAs in the logistic regression analysis. However, in all aneurysm cases, recanalization of the treated aneurysm was inversely associated with increased TI of the parent vessels.Conclusions TIs of intracranial arteries are associated with the occurrence of IA, especially in the outer curvature type. IAs with a high TI in the parent vessel showed good outcomes with endovascular treatment.

show abstract

“…It can also be defined as two markedly tortuous turns, kinking, or acute angulation of the artery with an angle between the two segments of more than 60°, or coil elongation of the artery resulting in 360° degrees of rotation. 23 An association between tortuosity and aneurysms was also shown in terms of vertebral arteries in the Virgilio et al study; 45 however, the association was not further confirmed by the Nasr et al study. 29 Tortuosity also plays a role in aortic aneurysm analysis.…”

Section: Discussionmentioning

confidence: 89%

Computer-aided analysis of middle cerebral artery tortuosity: association with aneurysm development

Kliś

Krzyżewski

Kwinta

et al. 2019

Journal of Neurosurgery

View full text Add to dashboard Cite

OBJECTIVE Blood vessel tortuosity may play an important role in the development of vessel abnormalities such as aneurysms. Currently, however, there are no studies analyzing the impact of brain blood vessel tortuosity on the risk of aneurysm formation. Therefore, the authors performed a computer-aided analysis of middle cerebral artery (MCA) tortuosity, especially among patients diagnosed with MCA aneurysms. METHODS Anatomy of the MCAs of 54 patients with unruptured MCA aneurysms was retrospectively analyzed, as was that of 54 sex-, age-, and vessel side-matched control patients without MCA aneurysms. From medical records, the authors obtained each patient's medical history including previous and current diseases and medications. For each patient, they calculated the following tortuosity descriptors: relative length (RL), sum of angle metrics (SOAM), triangular index (TI), product of angle distance (PAD), and inflection count metric (ICM). RESULTS Patients with an MCA aneurysm had significantly lower RLs (0.75 ± 0.09 vs 0.83 ± 0.08, p < 0.01), SOAMs (0.45 ± 0.10 vs 0.60 ± 0.17, p < 0.01), and PADs (0.34 ± 0.09 vs 0.50 ± 0.17, p < 0.01). They also had significantly higher TIs (0.87 ± 0.04 vs 0.81 ± 0.07, p < 0.01) and ICMs (3.07 ± 1.58 vs 2.26 ± 1.12, p < 0.01). Female patients had significantly higher RLs (0.76 ± 0.11 vs 0.80 ± 0.09, p = 0.03) than male patients. CONCLUSIONS Middle cerebral artery aneurysm formation is strongly associated with blood vessel tortuosity parameters, which can potentially be used to screen for patients at risk for MCA aneurysm formation.

show abstract

Vertebral Tortuosity Index in Patients with Non-Connective Tissue Disorder-Related Aneurysm Disease

Cited by 14 publications

References 18 publications

Increased tortuosity of basilar artery might be associated with higher risk of aneurysm development

Increased tortuosity of basilar artery might be associated with higher risk of aneurysm development

How Cerebral Vessel Tortuosity Affects Development and Recurrence of Aneurysm: Outer Curvature versus Bifurcation Type

Computer-aided analysis of middle cerebral artery tortuosity: association with aneurysm development

Contact Info

Product

Resources

About