Vertebroplasty comparing injectable calcium phosphate cement compared with polymethylmethacrylate in a unique canine vertebral body large defect model

Turner, Thomas M.; Urban, Robert M.; Singh, Kern; Hall, Deborah A.; Renner, Susan M.; Lim, Tae-Hong; Tomlinson, Michael J.; An, Howard S.

doi:10.1016/j.spinee.2006.12.007

Cited by 59 publications

(46 citation statements)

References 17 publications

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“…Cellular viability was measured using a Methyl Tetrazolium Salt (MTS) assay as previously described [36,37]. Briefly, SW1353 were allowed to attach in 24-well plates at a final density of 10,000 cells/cm 2 . After 24 h, culture medium was removed and 500 ml of rinsed ruthenium labelled hydrogel (case 2) were added in each well.…”

Section: Viability Of Chondrocytes Cultured In Presence Of Labelled Hmentioning

confidence: 99%

“…Nowadays, the needs for bone repair surgery focus more and more on sophisticated regenerative scaffolds, such as injectable calcium phosphate based material for minimally invasive surgical techniques [1][2][3][4][5][6][7][8][9][10]. In that context, two original devices made of biphasic calcium phosphate (BCP) granules suspended into polysaccharide-based media were designed in our laboratory about ten years ago [11][12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering

et al. 2009

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a b s t r a c tIn this paper we report a new method that permitted for the first time to selectively track a polysaccharide-based hydrogel on bone tissue explants, several weeks after its implantation. The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium complex and implanted into rabbit bone defects in order to investigate its in vivo degradation. 1, 2, 3 and 8 weeks after surgery, the bone explants were analyzed by synchrotron X-ray microfluorescence, infrared mapping spectroscopy, scanning electron microscopy, and optical microscopy after histological coloration. The results showed that the labelled polysaccharide-based hydrogel was likely to undergo phagocytosis that seemed to occur from the edge to the center of the implantation site up to at least the 8th week.

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Section: Viability Of Chondrocytes Cultured In Presence Of Labelled Hmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering

et al. 2009

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“…As the incidence of vertebral compression fractures continues to rise as our population ages (12), cement augmentation will no doubt be performed more extensively, and more information is needed about this relatively new procedure. Biomechanical studies of vertebroplasty have largely focused on the effects of cement augmentation on the strength and stiffness of single vertebrae, where the overall trend shows increased or maintained vertebral strength (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26), and decreased or maintained stiffness (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) except when a large volume of cement was injected (13). In contrast, multi-level spine models that more closely approximate physiological conditions are limited and more heterogeneous.…”

Section: Introductionmentioning

confidence: 99%

Effects of cement augmentation on the mechanical stability of multilevel spine after vertebral compression fracture

Tan¹,

Wang²,

Pelletier³

et al. 2016

J. Spine Surg.

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Background: Studies on the effects of cement augmentation or vertebroplasty on multi-level spine after vertebral compression fractures are lacking. This paper seeks to establish a 3-vertebrae ovine model to determine the impact of compression fracture on spine biomechanics, and to discover if cement augmentation can restore mechanical stability to fractured spine.Methods: Five lumbar spine segments (L1-L3) were obtained from 5-year-old female Merino sheep.Standardized wedge-compression fractures were generated in each L2 vertebra, and then augmented with polymethyl methacrylate (PMMA) cement mixed with 30% barium sulphate powder. Biomechanical pure moment testing in axial rotation (AR), flexion/extension (FE) and lateral bending (LB) was carried out in the intact, fractured and repaired states. Range of motion (ROM) and neutral zone (NZ) parameters were compared, and plain radiographs taken at every stage.Results: Except for a significant increase in ROM between the intact and fractured states in AR between L1 and L2 (P<0.05), there were no other significant differences in ROM or NZ between the other groups.There was a trend towards an increase in ROM and NZ in all directions after fracture, but this did not reach significance. Normal biomechanics was only minimally restored after augmentation. Conclusions:Results suggest that cement augmentation could not restore mechanical stability of fractured spine. Model-specific factors may have had a role in these findings. Caution should be exercised when applying these results to humans.

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“…Some authors suggest the use of this material even for the treatment of fractures in younger patients. Such a choice may be controversial: in spite of its excellent biomechanical capacity, it has no osteointegrative characteristics [2]. The use of a crystal, calcium phosphate cement (CPC), seems to be more interesting given its good biocompatibility and theoretical osteointegration: it should be reabsorbed slowly with time and ''substituted'' with bony tissue.…”

Section: Introductionmentioning

confidence: 99%

Treatment of typical amyelic somatic fractures with kyphoplasty and calcium phosphate cement: a critical analysis

Gioia¹,

Gogue²

2012

Eur Spine J

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Vertebroplasty comparing injectable calcium phosphate cement compared with polymethylmethacrylate in a unique canine vertebral body large defect model

Cited by 59 publications

References 17 publications

The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering

The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering

Effects of cement augmentation on the mechanical stability of multilevel spine after vertebral compression fracture

Treatment of typical amyelic somatic fractures with kyphoplasty and calcium phosphate cement: a critical analysis

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