Vertebroplasty in Multiple Myeloma: Outcomes in a Large Patient Series

Abstract

BACKGROUND AND PURPOSE:Despite the literature supporting the efficacy of vertebroplasty for treatment of osteoporotic vertebral compression fractures, few reports exist documenting its use in the treatment of compression fractures in multiple myeloma patients. Accordingly, we sought to characterize the imaging characteristics, clinical course, and outcomes in myeloma patients treated with vertebroplasty.

Percutaneous Vertebroplasty in Multiple Myeloma: Prospective Long-Term Follow-Up in 106 Consecutive Patients

“…In conclusion, this study, in line with other reported retrospective series [16,20], confirmed that PV is a safe ad effective treatment for of painful VCFs resulting from the progression of MM disease. PV produced pain relief and recovery from moderate to total disability, both of which were maintained during long-term follow-up.…”

“…Kyphoplasty (KP) [19] uses an inflatable bone tamp generally introduced bilaterally through a larger cannula before PMMA injection to restore vertebral height and to decrease PMMA leakage. Preliminary retrospective studies have demonstrated the effectiveness of PV [16,20] and KP [21,22] in controlling pain and improving the quality of life of patients with painful MM of the spine. Few studies have prospectively analyzed the clinical outcomes achieved by PV [23] and KP [17] in relatively small series of patients.…”

Limiting early mortality: Do's and don'ts in the management of patients with newly diagnosed multiple myeloma

“…Radiation, typically in low doses administered in few fractions, can lead to rapid improvement in pain but should be avoided in newly diagnosed patients in nonurgent circumstances, particularly when multiple lesions are presents and large fields are required. Vertebroplasty and kyphoplasty are often employed in the treatment of vertebral fracture and are associated with short term pain improvement [95][96][97].…”

CT fluoroscopy-guided percutaneous vertebroplasty in patients with multiple myeloma: analysis of technical results in 44 sessions with 67 vertebrae treated

“…Several reports have focused on the use of vertebroplasty, particularly in the treatment of osteolyses and compression fractures in myeloma patients (22)(23)(24)(25)(26)(27)(28)(29)(30). Conservative pain management with bed rest, bracing, bisphosphonates and analgesic drugs is often not sufficient to control the acute and chronic spinal pain accompanying pathologic fractures in myeloma patients.…”

“…McDonald et al (22) presented clinical outcome data from 67 MM patients undergoing vertebroplasty over a 7-year period. They reported a statistically significant improvement on the Roland-Morris Disability Questionnaire, as well as in the VAS values that their patients documented immediately after the procedure and during the follow-up period of up to 1 year.…”