Verteilung der karotidalen Intima-Media-Dicke bei Männern und Frauen mit und ohne koronare Herzerkrankung

The MRI study within the German National Cohort, a large-scale, population-based, longitudinal study in Germany, comprises comprehensive characterization and phenotyping of?a?total of 30?000 participants using 3-Tesla?whole-body MR imaging. A multi-centric study design was established together with dedicated core facilities for e.?g. managing incidental findings or providing quality assurance. As such, the study represents a unique opportunity to substantially impact imaging-based risk stratification leading to personalized and precision medicine. Supported by the developments in the field of computational science, the newly developing scientific field of radiomics has large potential for the future. In the present article we provide an overview on population-based imaging and Radiomics and conceptualize the rationale and design of the MRI study within the German National Cohort. Key Points: ??Population-based imaging and Radiomics constitute two emerging fields with great oppertunities and challenges for Radiology. ??As part of the MRI-study of the NAKO approximately 30 000 subjects will undergo 3 Tesla whole-body MRI. ??MR Imaging data is publicly accessable and will provide important insights into the natural history of disease processes and personalized risk profiles of the general population. Citation Format: ??Schlett CL, Hendel T, Weckbach S et?al. Population-Based Imaging and Radiomics: Rationale and Perspective of the German National Cohort MRI Study. Fortschr R?ntgenstr 2016; 188: 652???661

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Population-Based Imaging and Radiomics: Rationale and Perspective of the German National Cohort MRI Study

Schlett

Hendel

Weckbach

et al. 2016

Fortschr Röntgenstr

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Verteilung der karotidalen Intima-Media-Dicke bei Männern und Frauen mit und ohne koronare Herzerkrankung

Abstract: Compared to international studies similar CIMT distributions were found in this study using both continuous and percentile distributions. However, lower CIMT values were observed in older participants, which can be explained by exclusion of carotid plaque formation in CIMT measurements.

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Population-Based Imaging and Radiomics: Rationale and Perspective of the German National Cohort MRI Study

Population-Based Imaging and Radiomics: Rationale and Perspective of the German National Cohort MRI Study

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