Verteporfin attenuates trauma‐induced heterotopic ossification of Achilles tendon by inhibiting osteogenesis and angiogenesis involving<scp>YAP</scp>/β‐catenin signaling

Luo, Gang; Sun, Ziyang; Liu, Huan; Yuan, Zhengqiang; Wang, Wei; Tu, Bing; Li, Juehong; Fan, Cunyi

doi:10.1096/fj.202300568r

The FASEB Journal

2023

DOI: 10.1096/fj.202300568r

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Verteporfin attenuates trauma‐induced heterotopic ossification of Achilles tendon by inhibiting osteogenesis and angiogenesis involvingYAP/β‐catenin signaling

Gang Luo

Ziyang Sun

Huan Liu

et al.

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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2024

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Cited by 8 publications

References 51 publications

(94 reference statements)

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Disturbed glycolipid metabolism activates CXCL13-CXCR5 axis in senescent TSCs to promote heterotopic ossification

Chen,

Wu,

Wong

et al. 2024

Cell. Mol. Life Sci.

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Heterotopic ossification (HO) occurs as a common complication after injury, while its risk factor and mechanism remain unclear, which restricts the development of pharmacological treatment. Clinical research suggests that diabetes mellitus (DM) patients are prone to developing HO in the tendon, but solid evidence and mechanical research are still needed. Here, we combined the clinical samples and the DM mice model to identify that disordered glycolipid metabolism aggravates the senescence of tendon-derived stem cells (TSCs) and promotes osteogenic differentiation. Then, combining the RNA-seq results of the aging tendon, we detected the abnormally activated autocrine CXCL13-CXCR5 axis in TSCs cultured in a high fat, high glucose (HFHG) environment and also in the aged tendon. Genetic inhibition of CXCL13 successfully alleviated HO formation in DM mice, providing a potential therapeutic target for suppressing HO formation in DM patients after trauma or surgery.

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Disturbed glycolipid metabolism activates CXCL13-CXCR5 axis in senescent TSCs to promote heterotopic ossification

Chen,

Wu,

Wong

et al. 2024

Cell. Mol. Life Sci.

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show abstract

Cutaneous burn injury represents a major risk factor for the development of traumatic ectopic bone formation following blast-related extremity injury

Rowe,

Nwaolu,

Salinas

et al. 2024

Bone

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Angiogenesis in heterotopic ossification: From mechanisms to clinical significance

Li,

Ran,

Chen

et al. 2024

Life Sciences

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Verteporfin attenuates trauma‐induced heterotopic ossification of Achilles tendon by inhibiting osteogenesis and angiogenesis involvingYAP/β‐catenin signaling

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 8 publications

References 51 publications

Disturbed glycolipid metabolism activates CXCL13-CXCR5 axis in senescent TSCs to promote heterotopic ossification

Disturbed glycolipid metabolism activates CXCL13-CXCR5 axis in senescent TSCs to promote heterotopic ossification

Cutaneous burn injury represents a major risk factor for the development of traumatic ectopic bone formation following blast-related extremity injury

Angiogenesis in heterotopic ossification: From mechanisms to clinical significance

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