Vertex extradural hematoma in association with Paget′s disease of the skull

Ramesh, Vengalathur Ganesan; Kunjithapatham, Deiveegan; Soundappan, V

doi:10.4103/0028-3886.15077

Cited by 9 publications

(5 citation statements)

References 8 publications

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“…1,2 There have been a number of reports of extradural haematoma and it has been postulated that this may be partly due to the increased vascularity of bone affected by Paget's disease. 6,7 Treatment of Paget's disease is through disease control with reduction of pain and prevention of pathological fractures through the administration of bisphosphonates. Intravenous bisphosphonates are used in more severe cases and oral bisphosphonates for maintenance therapy as in this case.…”

Section: Discussionmentioning

confidence: 99%

An uncommon cause of headache and hearing loss

Gauden

Drummond

2011

Journal of Clinical Neuroscience

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Section: Discussionmentioning

confidence: 99%

An uncommon cause of headache and hearing loss

Gauden

Drummond

2011

Journal of Clinical Neuroscience

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“… A cartoon of the number of published case reports/series on Paget Disease of Bone from India from Pubmed and Google Scholar from 1963 to 2019. [ 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 ] The size of the dots is representative of the number of case reports from that state. Size expressed as a fraction (0.1cm X Number of cases) and for purpose of rep-resentation, the largest representation is shown as Square root of (0.1cm X Number of cases) …”

Section: Discussionmentioning

confidence: 99%

Is paget disease of bone more common in South India? Clinical characteristics, therapeutic outcome and follow-up of 66 patients from Tamil Nadu

Asirvatham

Kannan

Mahadevan

et al. 2020

Indian J Endocr Metab

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Introduction: Paget disease of bone (PDB) is a disorder of altered bone remodeling mainly characterized by increased osteoclastic activity. While the exact Indian prevalence remains unknown, a clustering of published cases suggests South Indian predominance. Objective: To study the clinico-biochemical profile and therapeutic response of patients with PDB and briefly review the epidemiology of PDB from an Indian perspective. Materials and Methods: Retrospective data was collected from the charts of patients who have been seen in endocrine out-patient clinics in Tamil Nadu over a 12-year period. Published literature on PDB from India was reviewed. Results: A total of 66 patients (71% males) predominantly from Tamil Nadu were studied. The mean age at presentation was 67 ± 8 years. Polyostotic involvement was seen in 89% and familial occurrence of PDB in 5 patients. Symptoms at presentation mainly included bone pain (51%) and skeletal deformities (18%). Scalp vein sign (21%) and sensorineural hearing loss (64%) were also noted. Incidental PDB detection by raised serum alkaline phosphatase (SAP) levels was observed in 17% and by abnormal fluorodeoxyglucose-positron emission tomography (FDG-PET) scan in 6% of cases. Mean SAP at presentation was 606 ± 438 IU/L (Normal, 76–140). Major skeletal site involvement includes pelvis (62.1%) and spine (34.8%). Mean (range) follow-up of the cohort was 3.4 yrs (1–12 yrs). In all, 64 subjects received zoledronate and two received alendronate, and mean (SD) SAP at 1-year was 73 ± 42 IU/L. All but two showed remission at the end of 1 year. Two had pathological fractures and two had sarcomas. A review of epidemiology of PDB in Indian literature clearly showed a South Indian predilection for unclear reasons. Conclusion: In our cohort of PDB, male gender, polyostotic involvement, and hearing impairment were noted in more than two-thirds of patients and single-dose intravenous zoledronate was effective in normalizing SAP in almost all patients. PDB is intriguingly more common in South India and this needs more exploration.

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“…Columella et al[ 11 ] mentioned oozing from fracture line and detachment of dura from bone as bleeding source. Ramesh[ 24 ] referred to a traumatic case with Paget’s disease in the absence of fracture or dural sinus injury. In a similar way of majority, we observed tear of sinus wall or arachnoid granulation as bleeding source.…”

Section: Discussionmentioning

confidence: 99%

A Series of Posttraumatik Midline Epidural Hematoma and Review of the Literature

Güçlü¹

2020

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Supratentorial midline epidural hematoma is rare but challenging in diagnosis and management. Indication for surgery can arise even following hospital admission. Being familiar to the presentation and watching out for direct and indirect signs on axial computed tomography (CT) such as suture diastasis or fracture traversing midline are essential to plan multi-planar CT enabling exact diagnosis including form and mass effect of hematoma. METHODS: Nine patients with midline epidural hematoma including two pediatric patients underwent surgery between 2013 and 2018. Pre-operative and post-operative patient status, radiological features, and surgical technique were analyzed. RESULTS: Four patients had deteriorating consciousness levels and two patients had paraparesis. All had fractures traversing midline and epidural hematomas with significant mass effect. They were operated through separated craniotomies around the midline and midline bone strip was used for dural tenting and as support for natural closure of bone flaps. No post-operative complications were developed. All patients were discharged with Glasgow Outcome Score of 5. CONCLUSION: Because of the rarity of the lesion and small number of patients, definitive conclusions may be misleading but we think that, in experienced hands, midline epidural hematomas can safely be operated on and, preservation of midline bone strip provides easier bleeding control.

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Vertex extradural hematoma in association with Paget′s disease of the skull

Cited by 9 publications

References 8 publications

An uncommon cause of headache and hearing loss

An uncommon cause of headache and hearing loss

Is paget disease of bone more common in South India? Clinical characteristics, therapeutic outcome and follow-up of 66 patients from Tamil Nadu

A Series of Posttraumatik Midline Epidural Hematoma and Review of the Literature

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