Vertical transmission in chikungunya infection

Senanayake, Manouri P; Senanayake, S. M. H. M. K.; Vidanage, Kaneeka; Gunasena, Sunethra; Lamabadusuriya, SP

doi:10.4038/cmj.v54i2.865

Cited by 38 publications

(38 citation statements)

References 9 publications

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“…Mother-to-child transmission of CHIKV was first reported during the 2005-2006 outbreak on La Réunion Island [36,37], with similar cases published afterwards in India and Sri Lanka [38,39]. This novel mode of transmission occurs during the peripartum maternal infection when there is insufficient time for the maternal production of protective antibodies.…”

Section: Chik and Pregnancymentioning

confidence: 87%

Emergence and clinical insights into the pathology of Chikungunya virus infection

Jaffar-Bandjee

Ramful

Gaüzère

et al. 2010

Expert Review of Anti-infective Therapy

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Major epidemics of Chikungunya have re-emerged with millions of cases worldwide. What was once largely a tropical disease in poorer countries is now recognized as a major global health issue. The disease is perpetuated by the alphavirus Chikungunya, and is transmitted by Aedes mosquitoes. The infection is highly symptomatic, with fever, skin rash and incapacitating arthralgia, which can evolve to chronic arthritis and rheumatism in elderly patients. Mother-to-child transmission, encephalitis, Guillain-Barré syndrome and deaths have been noted. In this article, we will highlight the epidemiological, clinical, virological and immunological aspects of the disease and mention the therapies that have been used during recent epidemics. Novel prevention measures to control the mosquito and a new vaccine are highly warranted.

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Section: Chik and Pregnancymentioning

confidence: 87%

Emergence and clinical insights into the pathology of Chikungunya virus infection

Jaffar-Bandjee

Ramful

Gaüzère

et al. 2010

Expert Review of Anti-infective Therapy

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“…Chikungunya virus (CHIKV) is an arthropod‐borne alphavirus that has caused several outbreaks throughout Africa and Asia (Jupp & McIntosh, ; McCrae, Henderson, Kirya, & Sempala, ; Mckintosh, Harwin, Paterson, & Westwater, ; Paupy, Kassa Kassa, Caron, Nkoghé, & Leroy, ; Peyrefitte et al, ; Sow et al, ). CHIKV is primarily transmitted to humans by mosquitoes within the Aedes genus, but vertical transmission of CHIKV from mother to child has also been documented (Ramful et al, ; Rao, Khan, & Chitnis, ; Senanayake, Senanayake, Vidanage, Gunasena, & Lamabadusuriya, ). Vector control strategies, such as insecticide distribution and public education programmes, have not demonstrated significant success in preventing CHIKV transmission thus far (Weaver & Lecuit, ).…”

Section: Introductionmentioning

confidence: 99%

Combining anti‐IgM and IgG immunoassays for comprehensive chikungunya virus diagnostic testing

Mendoza

Robinson

Dimitrova

et al. 2019

Zoonoses and Public Health

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Chikungunya virus (CHIKV) is a mosquito‐borne pathogen that causes CHIKV fever. Definitive diagnosis is crucial for patients experiencing symptoms similar to other arboviral diseases because they can vary in clinical consequences. An increasing number of patients experience long‐term rheumatic effects of CHIKV infection, but these cases may not be optimally detected by molecular assays and anti‐CHIKV IgM ELISAs (M‐ELISAs) used for confirmation and screening, respectively. The subsequent confirmatory serological test, the plaque reduction neutralization test (PRNT), is laborious and time‐consuming. In this study, we evaluated a new diagnostic algorithm in which the M‐ELISA is conducted in parallel with an anti‐CHIKV IgG ELISA (G‐ELISA) and observed that the Euroimmun M‐ELISA combined with the Euroimmun G‐ELISA or the Abcam G‐ELISA exhibited excellent sensitivity and specificity for CHIKV. The combinations demonstrated perfect and near perfect inter‐rater agreement with the PRNT, respectively, suggesting their potential to be used as alternatives to the confirmatory serological PRNT assay for CHIKV.

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“…Furthermore, concern has recently arisen because of severe forms of CHIKV infection that were previously unrecorded, including encephalopathy and numerous deaths. 12,13 Studies have also shown that CHIKV can be vertically transmitted from mother to fetus, leading to severe neonatal infection, 3,14 and likely fetal death in early gestation. 15 …”

Section: Introductionmentioning

confidence: 99%

Chikungunya Virus: A Novel and Potentially Serious Threat to New Zealand and the South Pacific Islands

Derraik¹,

Slaney²,

Nye³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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There has never been a locally transmitted outbreak of mosquito-borne disease in New Zealand, but the risk of an outbreak occurring is increasing with on-going interceptions of exotic mosquito vectors across its border, increasing traffic of goods and passengers, higher numbers of viremic travelers arriving, and local, regional, and global environmental change. The risk posed to New Zealand by chikungunya virus is potentially high because of the transmissibility of this virus in subtropical climates, compounded by a population that is predominantly immunologically naive to exotic arboviruses. However, risk reduction in New Zealand should not be considered in isolation but must be viewed within a wider South Pacific context. In this report, we discuss the potential threat posed by chikungunya to the region, focusing in particular on New Zealand, and re-emphasizing the need for a South Pacific–wide approach towards mosquito-borne disease prevention.

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Vertical transmission in chikungunya infection

Cited by 38 publications

References 9 publications

Emergence and clinical insights into the pathology of Chikungunya virus infection

Emergence and clinical insights into the pathology of Chikungunya virus infection

Combining anti‐IgM and IgG immunoassays for comprehensive chikungunya virus diagnostic testing

Chikungunya Virus: A Novel and Potentially Serious Threat to New Zealand and the South Pacific Islands

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