Vertical Transmission of Hepatitis C Virus: Systematic Review and Meta-analysis

Beňová, Lenka; Mohamoud, Yousra A.; Calvert, Clara; Abu‐Raddad, Laith J.

doi:10.1093/cid/ciu447

Cited by 420 publications

(423 citation statements)

References 41 publications

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“…Simple distribution Naïve Bayes and decision tree created by Rapid I version 4.6 emphasized the level of maternal HCV-related vertical transmission; > 3× 10 6 IU should be considered as the high level of vertical prediction, reported in our previous work [13] , and CS should be likely an important route of global HCV transmission especially in developing countries [ Figures 1 and 2]. However, the level of maternal viremia is still a matter of scientific debate in such vertical transmission.…”

Section: Discussionmentioning

confidence: 99%

“…The risk of transmission (one in every 20 children) delivered by chronic HCV-infected women highlights that vertical transmission likely constitutes the primary transmission route among children. These updated estimates are considered as a basis for decision making in prioritization of the research into risk-reducing measures [6][7][8] . Recently, data mining (DM) programming allows clinicians to extract hidden factors that lead to such disease progression or regression in an artificial intelligence manner [9] .…”

Section: Introductionmentioning

confidence: 99%

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Ongoing transmission of HCV: Should cesarean section be justified? Data mining discovery

Elrazek

Saab

Foad

et al. 2017

Journal of Translational Internal Medicine

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Background and Objectives:Over the past few decades, cesarean section (CS) rates are steadily increasing in most of the middle-and high-income countries. However, most of the pregnant women (particularly undergoing CS) are not screened for hepatitis C virus (HCV); hence, neonates born to HCV-positive mother could be a source of future HCV infection. In this study, the role of the CS and other surgical interventions in HCV transmission in Egypt, the highest endemic country of HCV-4, was investigated. Methods: From January to June 2016, a prospective cohort study was conducted among 3,836 pregnant women in both urban and rural areas across Egypt for HCV screening in both mothers and neonates born to HCV-positive mother. All pregnant women were screened during third trimester or just before delivery, neonates born to HCV-positive mothers were evaluated within 24-h postdelivery to record vertical transmission cases. Data mining (DM)-driven computational analysis was used to quantify the findings. Results: Among 3,836 randomized pregnant women, HCV genotype 4 was identified in 80 women (2.08%). Out of 80 HCV-infected women, 18 have experienced surgical intervention (22.5%) and 62 CS (77.5%). HCV vertical transmission was identified in 10 neonates, 10/80 (12.5%). Conclusion: Screening women who had experienced surgical intervention or CS during child bearing period and before pregnancy might prevent HCV mother-to-child transmission (MTCT). CS should be ethically justified to decrease global HCV transmission.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ongoing transmission of HCV: Should cesarean section be justified? Data mining discovery

Elrazek

Saab

Foad

et al. 2017

Journal of Translational Internal Medicine

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“…Mechanisms leading to perinatal HCV transmission are currently not well understood. Likely risk factors include perinatal practices (fetal scalp monitoring and caesarean‐section delivery), extended exposure to maternal blood, high levels of HCV viremia during pregnancy, and co‐infection with human immunodeficiency virus (HIV) 15, 16, 17, 18, 19. Although some studies have challenged several of these assumptions,20, 21 a recent meta‐analysis concluded that maternal HIV co‐infection is the most important determinant of the risk of perinatal transmission 15…”

Section: Epidemiologymentioning

confidence: 99%

Hepatitis C virus infection in children and adolescents

Squires

Balistreri

2017

Hepatology Communications

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“…Results from a recent meta-analysis suggest that the risk of vertical transmission from anti-HCV positive and RNA-positive women is about 5.8% (95% CI, 4.2%-7.8%), and the risk to children born to an anti-HCV positive mother with spontaneous clearance of infection (RNA negative) was insignificant (37,38).…”

Section: Vertical Transmissionmentioning

confidence: 99%

Hepatitis C in Canada and the importance of risk-based screening

Ha¹,

Totten²,

Pogany³

et al. 2016

Can Commun Dis Rep

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Chronic hepatitis C (CHC) remains a public health issue affecting an estimated 220,000 individuals in Canada. In 2011, approximately 44% of those with CHC were unaware of their infection. Hepatitis C is infectious in origin, and if left untreated, can lead to significant morbidity and mortality in its chronic form, including liver cirrhosis, hepatocellular carcinoma and liver failure. These health outcomes are associated with comorbidities, adding a burden to the Canadian health care system. Recent advancements in the treatment of hepatitis C have changed the clinical landscape.In Canada, the prevalence of incident cases is higher in specific population groups. Injection drug use (IDU) currently accounts for the highest proportion of new hepatitis C virus (HCV) infection. It is unclear to what extent HCV infection through health care or personal services use contributed to current prevalent cases of CHC. The Canadian Task Force on Preventive Health Care (CTFPHC) is currently reviewing the evidence for different approaches to HCV screening and the benefits and harms of screening. Risk-based screening remains critical to detecting hepatitis C as knowing one's status has been linked to the cascade of care and improved population health outcomes. This article intends to highlight risk factors associated with the acquisition of HCV so that health care providers can screen, where appropriate, and detect CHC.

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Vertical Transmission of Hepatitis C Virus: Systematic Review and Meta-analysis

Abstract: Updated pooled estimates of vertical hepatitis C (HCV) infection risk to children of HCV RNA–positive mothers ranges between 5.8% and 10.8%, depending on maternal HIV coinfection. Additional risk factors need to be captured and reported by future studies.

Cited by 420 publications

References 41 publications

Ongoing transmission of HCV: Should cesarean section be justified? Data mining discovery

Ongoing transmission of HCV: Should cesarean section be justified? Data mining discovery

Hepatitis C virus infection in children and adolescents

Hepatitis C in Canada and the importance of risk-based screening

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