Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2: Current Evidence and Perspectives

Abstract

Evidence of SARS-CoV-2 intrauterine vertical transmissionSince the onset of the pandemic, worldwide efforts were made to explore the possibility of vertical transmission of SARS-CoV-2. The first study from China reported a retrospective cohort of nine pregnant women with SARS-CoV-2 infection, by RT-PCR analyses of the virus, on babies born to mothers with SARS-CoV-2 infection and their paired amniotic fluid and cord blood. The study indicated no evidence of intrauterine vertical transmission in late pregnancy. 14 Subsequently, more studies have reported similar results and failed to

SARS-CoV-2 infection and pregnancy: clinical update and perspective

“…[16] Evidence indicated that in utero transmission of SARS-CoV-2 is possible based on the detection of SARS-CoV-2 in intrauterine tissue samples, such as amniotic fluid, placenta, and umbilical cord plasma. [17] Besides, placental expression of ACE2 and transmembrane protease serine 2 (TMPRSS2) required for SARS-CoV-2 entering the cells makes the transplacental transmission of SARS-CoV-2 theoretically feasible. [17] However, the rates of intrauterine vertical transmission of SARS-CoV-2 seem to be uncommon.…”

“…[17] However, the rates of intrauterine vertical transmission of SARS-CoV-2 seem to be uncommon. [17] Additionally, the data on the safety of breastfeeding among mothers infected with SARS-CoV-2 are reassuring. [17] To date, the long-term health consequences of maternal SARS-CoV-2 infection for both the mother and offspring remain largely unclear.…”

“…[17] Additionally, the data on the safety of breastfeeding among mothers infected with SARS-CoV-2 are reassuring. [17] To date, the long-term health consequences of maternal SARS-CoV-2 infection for both the mother and offspring remain largely unclear. A 1-year follow-up of 7772 live births of whom 222 births with SARS-CoV-2 exposure in utero suggested that prenatal SARS-CoV-2 infection was associated with an 86% increased risk for offspring neurodevelopmental disorder, even after adjustment for confounders including PTB.…”

“…[ 17 ] Besides, placental expression of ACE2 and transmembrane protease serine 2 (TMPRSS2) required for SARS-CoV-2 entering the cells makes the transplacental transmission of SARS-CoV-2 theoretically feasible. [ 17 ] However, the rates of intrauterine vertical transmission of SARS-CoV-2 seem to be uncommon. [ 17 ] Additionally, the data on the safety of breastfeeding among mothers infected with SARS-CoV-2 are reassuring.…”

“…[ 17 ] However, the rates of intrauterine vertical transmission of SARS-CoV-2 seem to be uncommon. [ 17 ] Additionally, the data on the safety of breastfeeding among mothers infected with SARS-CoV-2 are reassuring. [ 17 ]…”