Very early aortic responses during atherosclerosis induction in rabbits: Measurement by duplex ultrasound

Chin, Hyunsook; Liu, C.R.; Liu, C.H.; Blankenhorn, David H.

doi:10.1016/0021-9150(90)90123-z

Cited by 7 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Abnormalities in vasocontractile responses have been report ed in animals with at heroscle rosis i n d uc e d b y h y p e r c h ol e s t e ro l e mi a . 5 -Hydroxytryptamine-induced contraction is known to be increased in arteries of Watanabe heritable hyperlipidemic (WHHL) rabbits (Yokoyama et al, 1983) as well as in those of rabbits with diet-induced hyperlipidemia (Henry and Yokoyama, 1980;Merkel et al, 1990;Chin et al, 1990). However, the reported change in angiotensin II contraction in atherosclerotic vessels is not consistent (Merkel et al, 1990;Dam et al, 1997;Yang et al, 1998).…”

Section: Introductionmentioning

confidence: 58%

“…The present study is the first to demonstrate that angiotensin II-induced contraction was also specifically attenuated in the abdominal aorta of WHHL rabbits, while their 5-hydroxytryptamine-induced contraction was not significantly different from the aorta of control rabbits. However, both the abdominal aorta and the thoracic aorta of diet-induced atherosclerotic rabbits showed augmented contractile responses to 5-hydroxytryptamine (Henry and Yokoyama, 1980;Merkel et al, 1990;Chin et al, 1990). The WHHL rabbit aorta has also been reported to show increased contractility in response to 5-hydroxytryptamine (Yokoyama et al, 1983).…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Diminution of angiotensin II-induced contraction of the abdominal aorta isolated from Watanabe heritable hyperlipidemic rabbits

Tasaki

Wakabayashi

Shishido

et al. 2005

J. Smooth Muscle Res.

View full text Add to dashboard Cite

The purpose of this study was to investigate the changes in vasocontractile responses in atherosclerosis, using abdominal aortic strips isolated from Watanabe heritable hyperlipidemic (WHHL) rabbits and Japanese White (control) rabbits. The aortic strips from WHHL rabbits showed a significantly lower contractile response to angiotensin II than that in strips from control rabbits. The contractile responses to phenylephrine and 5-hydroxytryptamine were not different in WHHL and control groups. The contractile response to angiotensin II was higher in endothelium-denuded aortic strips than in endothelium-intact strips, but to a greater extent in the control group than in the WHHL group. The contractile response to angiotensin II in the absence of the endothelium was also lower in the WHHL group than in the control group. Pretreatment with N G -nitro-Larginine significantly increased the contractile response to angiotensin II in the endothelium-intact aortic strips in both the WHHL and control groups, while pretreatment with diclofenac did not affects the aortic contractile response to angiotensin II. The contractile responses to angiotensin II in the presence of N G -nitro-L-arginine and diclofenac were lower in the WHHL group than in the control group. The contractile response to angiotensin II in the presence of PD123319 was also lower in the WHHL group than in the control group. Endothelium-dependent relaxation by acetylcholine occurred to the some extent in the WHHL and control groups. These results suggest that the WHHL rabbit abdominal aorta displays attenuated angiotensin II-induced contraction, mainly due to an abnormality in the angiotensin II-specific contractile pathway of the medial smooth muscle.

show abstract

Section: Introductionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 97%

Diminution of angiotensin II-induced contraction of the abdominal aorta isolated from Watanabe heritable hyperlipidemic rabbits

Tasaki

Wakabayashi

Shishido

et al. 2005

J. Smooth Muscle Res.

View full text Add to dashboard Cite

show abstract

“…Ultrasound evaluation of the aorta in rabbits has been performed in the past mostly to evaluate the extent of atherosclerotic plaques in response to a hypercholesterolemic diet. Intravascular ultrasound has been used to document endothelial dysfunction but has never been compared to ex vivo evaluation of endothelial function on aortic rings [1-5]. Our method is much less invasive for the animals than intravascular ultrasound.…”

Section: Discussionmentioning

confidence: 99%

“…Historically, evaluation of endothelial function in small animals has been performed on isolated vessel segments, or vessels exposed by surgical procedures. Very few attempts were made to develop a method of analysis of endothelium-dependent relaxation in vivo [1-5]. In those studies, an invasive intravascular ultrasound approach was used.…”

Section: Introductionmentioning

confidence: 99%