Very early discharge versus early discharge versus non-early discharge in children with cancer and febrile neutropenia

Loeffen, Erik A. H.; Poele, Esther M. te; Tissing, Wim J. E.; Boezen, H. Marike; Bont, Eveline S.J.M. de

doi:10.1002/14651858.cd008382.pub2

Cited by 19 publications

(18 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several study groups advise that patients should remain hospitalized between courses, especially during induction therapy. Although patients may often be too sick to leave the hospital, several previous studies did not show a benefit of mandatory hospitalization in reducing infections, or adverse effects of early discharge after febrile episodes (Sung et al , ; Loeffen et al , ). Moreover, the risk of nosocomial infections, e.g.…”

Section: Discussionmentioning

confidence: 99%

Differences in infection prophylaxis measures between paediatric acute myeloid leukaemia study groups within the international Berlin–Frankfürt–Münster (I‐BFM) study group

et al. 2018

View full text Add to dashboard Cite

Prevention of infections is of obvious relevance in paediatric patients with acute myeloid leukaemia (AML). However, recommendations are often non-specific and supported by low-quality evidence, resulting in divergent infection preventive regimens. Using a web-based survey, we investigated the infection prophylaxis guidelines of 22 paediatric AML study groups affiliated to the international Berlin-Frankfürt-Münster study group. In order to evaluate differences in daily practice among hospitals, representatives (n = 27) from the Nordic Society for Paediatric Haematology and Oncology-Dutch-Belgium-Hong Kong - AML study group participated in a slightly modified survey. Seven study groups (32%) advise gram-negative antibiotic prophylaxis, mainly with fluoroquinolones (n = 6). Gram-positive prophylaxis is prescribed by eight groups (36%). Over 60% of the study groups prescribe food and social restrictions, but the specific topics and strictness differ widely. According to the hospital-based survey, sites roughly comply with common study group guidelines. However, the use of any gram-negative antibiotic prophylaxis, the specific prophylactic antifungal agent and the strictness of the food and social restrictions differ substantially between the hospitals. Despite a long history of close collaboration, many differences are still present between the affiliated groups. The results of this survey provide an appropriate baseline measure to study the emergence and impact of future guidelines on infection prophylaxis in paediatric AML.

show abstract

Section: Discussionmentioning

confidence: 99%

Differences in infection prophylaxis measures between paediatric acute myeloid leukaemia study groups within the international Berlin–Frankfürt–Münster (I‐BFM) study group

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The 2012 guidelines advised using one of six different published clinical decision rules to stratify for this risk . But there are very limited data in children to enhance the safe use of risk‐adapted strategies . It has recently been shown that this absence of validity may be related to significant methodological biases during the derivation of these decision rules .…”

Section: Discussionmentioning

confidence: 99%

“…18 But there are very limited data in children to enhance the safe use of risk-adapted strategies. 25 It has recently been shown that this absence of validity may be related to significant methodological biases during the derivation of these decision rules. 26,27 Therefore, the development of new clinical decision rules, derived and validated according to rigorous methodological standards, is needed, 28,29 with consensual definitions between centers.…”

Section: Discussionmentioning

confidence: 99%

Risk‐stratification management of febrile neutropenia in pediatric hematology‐oncology patients: Results of a French nationwide survey

Delebarre

Tiphaine

Martinot

et al. 2016

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

“…11 Neutropenia occurs frequently in patients receiving cancer care and is caused by cytotoxic therapy or malignant neoplasms affecting the bone marrow. 11,12 Because the presence of neutrophils was found to be important for the skin manifestation of a brown recluse spider bite, 9,10 we reviewed the symptomatology of such bites among patients, including those with neutropenia, who were cared for at St. Jude Children’s Research Hospital (St. Jude). Here, we describe the characteristics and severity of local and systemic signs of loxoscelism and evaluate the severity of the disease in patients with and without neutropenia.…”

Section: Introductionmentioning

confidence: 99%

Brown Recluse Spider Bites in Patients With Neutropenia: A Single-institution Experience

Hijano¹,

Otterson²,

Homsi

et al. 2019

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

Brown recluse spider bites can cause local and systemic signs, including rash, dermonecrosis, edema, hemolysis, and acute kidney failure. These are mostly attributed to sphingomyelinase D, the main toxin. To evaluate the severity of the disease in pediatric patients with and without neutropenia, we retrospectively reviewed records of patients treated at St. Jude Children's Research Hospital between 1970 and 2015 and identified 19 patients who met the inclusion criteria. Variables of interest included the type of underlying illness, presence of neutropenia, number of days of hospitalization, disease signs and outcome of the bite, and treatments administered. We used descriptive statistics to summarize the manifestations and severity of spider bites in patients with and without neutropenia. Six patients experienced pain from the bite, 11 had erythema, 7 developed edema, and 5 had fever. The response to spider bites in neutropenic patients was no milder than that in non-neutropenic individuals. Six patients developed systemic complications. Compared with non-neutropenic patients, neutropenic patients had antibiotics prescribed more often and experienced longer hospital stays. Spider bites do not seem to have a different clinical course in neutropenic patients. Therefore, a conservative approach may be best for these patients, with close monitoring and local wound care.

show abstract

Very early discharge versus early discharge versus non-early discharge in children with cancer and febrile neutropenia

Abstract: (2016). Very early discharge versus early discharge versus non-early discharge in children with cancer and febrile neutropenia. Cochrane database of systematic reviews (Online), (2), [008382].

Cited by 19 publications

References 27 publications

Differences in infection prophylaxis measures between paediatric acute myeloid leukaemia study groups within the international Berlin–Frankfürt–Münster (I‐BFM) study group

Differences in infection prophylaxis measures between paediatric acute myeloid leukaemia study groups within the international Berlin–Frankfürt–Münster (I‐BFM) study group

Risk‐stratification management of febrile neutropenia in pediatric hematology‐oncology patients: Results of a French nationwide survey

Brown Recluse Spider Bites in Patients With Neutropenia: A Single-institution Experience

Contact Info

Product

Resources

About