Very High Frequency of the Polymorphism for the Insulin Receptor Substrate 1 (IRS-1) at Codon 972 (Glycine972Arginine) in Southern Italian Women with Polycystic Ovary Syndrome

Pappalardo, Maria; Russo, Giuseppina T.; Pedone, Antonio; Pizzo, Alfonsa; Borrielli, Irene; Stabile, Gaspare; Artenisio, Alfredo Carducci; Amato, Angélica Amorim; Calvani, Menotti; Cucinotta, Domenico; Trimarchi, Francesco; Benvenga, Salvatore

doi:10.1055/s-0030-1249020

Cited by 28 publications

(29 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ioannidis et al published a meta-analysis on IRS-1 Gly972Arg polymorphism, and got conclusions that the Arg972 allele was associated with an increased risk for developing PCOS [16]. But recent four researches in the association between IRS-1 Gly972Arg polymorphism and PCOS still had different conclusions [19][20][21][22]. We excluded in Asia population were limited, subgroup analyses were not considered in our research.…”

Section: Gly972arg Polymorphismmentioning

confidence: 88%

“…After review, a total of 16 published articles reported on the relationship between these two IRS gene polymorphisms and PCOS met the inclusion criteria [12][13][14][15][19][20][21][22][23][24][25][26][27][28][29], 15/16 were about the Gly972Arg polymorphism, 5/16 were about the Gly1057Asp polymorphism. These articles were published between 2001 and 2011.…”

Section: Eligibility Of Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Association of IRS-1 and IRS-2 genes polymorphisms with polycystic ovary syndrome: a meta-analysis

Ruan

Xie

2012

Endocr J

View full text Add to dashboard Cite

POLYCYSTIC OvarY SYndrOme (PCOS)is one of the most common heterogeneous endocrine disorders, which affect 5%-10% of women in reproductive age and is a leading causes of female infertility [1]. It is characterized by menstrual irregularity, hyperandrogenism, insulin resistance, and increased risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) [2,3]. Candidate genes for etiology of PCOS involve in ovarian and adrenal steroidogenesis, steroid hormone actions, gonadotropin action and regulation, insulin action and secretion, energy homeostasis, chronic inflammation and others [4]. Yet the "PCOS genes" remain elusive. Insulin resistance is a key component in the pathogenesis of PCOS and the predisposition to type 2 diabetes [5,6], however, the mechanisms for defects in insulin signaling in the disorder are comAssociation of IRS-1 and IRS-2 genes polymorphisms with polycystic ovary syndrome: a meta-analysis Yuan Ruan, Jianhua Ma and Xiaojing Xie Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China abstract. Insulin resistance (IR) plays an important role in the pathogenesis of polycystic ovary syndrome (PCOS) which is a common disorder in premenopausal women. The association between the single nucleotide polymorphisms (SNPs) of insulin receptor substrate (IRS) gene and PCOS in several populations has been studied, but the results are conflicting. The aim of this study was undertaken to investigate association of IRS-1 and IRS-2 genes polymorphisms with PCOS by conducting a meta-analysis. Literature search was conducted through PubMed and EMBASE databases (up to July 31, 2011). Fifteen articles with 1,358 cases and 1,561 controls were enrolled in the meta-analysis of the association between Gly972Arg variant and PCOS, and five articles with 519 cases and 883 controls were enrolled in the meta-analysis of Gly1057Asp variant. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using fixed and random-effects models. The Q-statistic test was used to assess heterogeneity, and Begg's test and Egger's test were used to evaluate publication bias. Sensitivity analysis was also performed. Our results indicated that A allele of Gly972Arg conferred a significantly increased risk of PCOS compared with G allele (OR = 1.91, 95% CI: 1.36-2.68). However, in Gly1057Asp polymorphism the OR of allele A vs. G is 0.92 (95% CI: 0.72, 1.18). Our meta-analysis suggested that IRS-1 Gly972Arg polymorphism might be considered a significant risk for PCOS. Otherwise, no significant associations were observed in IRS-2 Gly1057Asp polymorphism which needs to be further confirmed by further studies.Key words: Insulin receptor substrate, Polymorphisms, Polycystic ovary syndrome, Meta-analysis plex and have not been fully elucidated [7,8].Insulin receptor substrates proteins (IRS) are critical for insulin mediated signal transduction in insulin target tissues. Several studies have shown that two common polymorphisms in IRS particularly Gly972Arg (rs1801278) in ...

show abstract

Section: Gly972arg Polymorphismmentioning

confidence: 88%

Section: Eligibility Of Studiesmentioning

confidence: 99%

Association of IRS-1 and IRS-2 genes polymorphisms with polycystic ovary syndrome: a meta-analysis

Ruan

Xie

2012

Endocr J

View full text Add to dashboard Cite

show abstract

“…In addition, polymorphism studies are mostly dependent on ethnicity and variability within different geographic regions which could affect study results. Recently a study was done to find out the prevalence of different codons of IRS-1 in PCOS patients in different European ethnicities with different results [15,16]. The present study was therefore undertaken to investigate the frequency of IRS1Gly972Arg and IRS2 Gly1057Asp polymorphisms and to compare the prevalence of these two polymorphisms in PCOS patients and non-diabetic healthy women in Iranian subjects.…”

Section: Introductionmentioning

confidence: 95%

Prevalence of the insulin receptor substrate-1(IRS-1) Gly972Arg and the insulin receptor substrate-2(IRS-2) Gly1057Asp polymorphisms in PCOS patients and non-diabetic healthy women

Rashidi

Azizy

Najmeddin

et al. 2011

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…However, some articles reported associations of Gly972Arg and Gly1057Asp polymorphisms with PCOS, but the results of these studies were conflicting. Recent four researches in the association between IRS-1 Gly972Arg polymorphism and PCOS still had different conclusions [38][39][40][41]. Very recent meta-analysis by Ruan Y in 2012 concluded that IRS-1 Gly972Arg polymorphism is associated with PCOS, and this variation might be considered as a risk factor for PCOS further this study also concluded that no significant association was detected between IRS-2 Gly1057Asp polymorphism and PCOS [12].…”

Section: Irs1 -Gly972arg Polymorphismmentioning

confidence: 81%

Past, Present and Future of Insulin Gene and Its Related Genes In Relation To Polycystic Ovary Syndrome

Kumar¹

2014

J Mol Genet Med

View full text Add to dashboard Cite

Polycystic ovary syndrome is the most common endocrinal disorder and is associated with infertility. Insulin resistance is a key component in the pathogenesis of PCOS and the predisposition to Type 2 diabetes mellitus. The existing literature supports a strong basis of PCOS clusters in families. However, due to the genetic and phenotypic heterogeneity of PCOS and the lack of large cohort studies and identification of specific contributing genes to date have yielded only few conclusive results. Although several loci have been proposed as PCOS genes including CYP11A, the insulin gene, and a region near the insulin receptor, the strongest case can be made for the region near the insulin receptor gene. Insulin receptor substrates proteins (IRS) are critical for insulin mediated signal transduction in insulin target tissues. Several studies have shown that IRS-1 Gly972Arg polymorphism might be the factor causing susceptibility to Type 2 diabetes mellitus (T2DM) and are associated with phenotypic features of PCOS. In this article we reviewed the current status of the genetic analysis of insulin (INS), insulin receptor (INSR), insulin receptor substrate (IRS) in relation to polycystic ovary syndrome, an infertility disorder in females.

show abstract

Very High Frequency of the Polymorphism for the Insulin Receptor Substrate 1 (IRS-1) at Codon 972 (Glycine972Arginine) in Southern Italian Women with Polycystic Ovary Syndrome

Cited by 28 publications

References 18 publications

Association of IRS-1 and IRS-2 genes polymorphisms with polycystic ovary syndrome: a meta-analysis

Association of IRS-1 and IRS-2 genes polymorphisms with polycystic ovary syndrome: a meta-analysis

Prevalence of the insulin receptor substrate-1(IRS-1) Gly972Arg and the insulin receptor substrate-2(IRS-2) Gly1057Asp polymorphisms in PCOS patients and non-diabetic healthy women

Past, Present and Future of Insulin Gene and Its Related Genes In Relation To Polycystic Ovary Syndrome

Contact Info

Product

Resources

About