Very Large Metastases to the Brain: Retrospective Study on Outcomes of Surgical Management

Gattozzi, Domenico A.; Alvarado, Anthony M.; Kitzerow, Collin; Funkhouser, Alexander; Bimali, Milan; Moqbel, Murad; Chamoun, Roukoz

doi:10.1016/j.wneu.2018.05.120

Cited by 5 publications

(1 citation statement)

References 33 publications

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“…Since previous prospective studies using single-fraction SRS for the treatment of BMs have not included lesions larger than 4 cm, we recommend multi-fraction SRT for these lesions if technically feasible. Nevertheless, SRT is currently discouraged for tumors larger than 6 cm due to lack of evidence ( 52 ).…”

Section: Resultsmentioning

confidence: 99%

CSCO expert consensus on the diagnosis and treatment of breast cancer brain metastasis

Wang¹,

Chen²,

Yang³

et al. 2022

Transl Breast Cancer Res

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Breast cancer is one of the most common malignancies among women worldwide. According to the International Agency for Research on Cancer, breast cancer affected more Chinese women than any other cancer in 2020. The brain is an increasingly common metastatic sites of breast cancer. Although the risk of developing brain metastases (BMs) is lower in breast cancer than in lung cancer and melanoma, due to its high prevalence, it is the second most common cause of BM among solid tumors, being second only to lung cancer. The incidence of breast cancer brain metastasis (BCBM) differs by molecular subtype. Half of patients with advanced human epidermal growth factor receptor-2 (HER2)-positive and one-third of patients with triple-negative breast cancer (TNBC) develop BM. The clinical manifestations of leptomeningeal metastasis (LM) are often non-specific and may manifest as a variety of signs and symptoms, mainly including brain parenchyma involvement and meningeal irritation syndromes cranial nerve involvement, increased

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Section: Resultsmentioning

confidence: 99%