Very low birth weight infants have only few adverse events after timely immunization

Furck, AK; Richter, Jost Wigand; Kattner, E.

doi:10.1038/jp.2009.112

Cited by 17 publications

(6 citation statements)

References 17 publications

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“…16 Several studies have found an increased risk of events leading to new requirements for respiratory support, especially in ELBW infants with significant lung disease, a history of sepsis during hospitalization, 17 and pre-immunization apnea, 18 though others showed no increased incidence in cardiorespiratory events after immunization among hospitalized infants in the NICU. 19,20 These studies used much smaller cohorts than the current study. One randomized controlled trial examining adverse events after DTaP reported no difference in the incidence of adverse cardiorespiratory events, only one immunization.…”

Section: Discussionmentioning

confidence: 87%

Adverse Events After Routine Immunization of Extremely Low-Birth-Weight Infants

et al. 2015

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Importance Immunization of extremely low-birth-weight (ELBW) infants in the neonatal intensive care unit (NICU) is associated with adverse events, including fever and apnea or bradycardia, in the immediate postimmunization period. These adverse events present a diagnostic dilemma for physicians, leading to the potential for immunization delay and sepsis evaluations.Objective To compare the incidence of sepsis evaluations, need for increased respiratory support, intubation, seizures, and death among immunized ELBW infants in the 3 days before and after immunization.

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Section: Discussionmentioning

confidence: 87%

Adverse Events After Routine Immunization of Extremely Low-Birth-Weight Infants

et al. 2015

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“…Several studies have reported increased cardiorespiratory events in preterm infants after immunizations, but others have not found this association, which may reflect different maturational stages at the time of administration, different vaccine combinations, or variations in methods for assessing apnea. ( 45 – 47 ) Nevertheless, it is quite possible that even a relatively minor stress such as immunizations may destabilize preterm infants causing them to revert to immature breathing patterns of apnea or PB.…”

Section: Discussionmentioning

confidence: 99%

Clinical associations with immature breathing in preterm infants: part 2—periodic breathing

et al. 2016

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Background Periodic breathing (PB) is a normal immature breathing pattern in neonates that, if extreme, may be associated with pathologic conditions. Methods We used our automated PB detection system to analyze all bedside monitor chest impedance data on all infants <35 weeks’ gestation in the University of Virginia Neonatal Intensive Care Unit from 2009-2014 (n=1211). Percent time spent in PB was calculated hourly (>50 infant-years’ data). Extreme PB was identified as a 12h period with PB >6 standard deviations above the mean for gestational age (GA) and post-menstrual age (PMA) and >10% time in PB. Results PB increased with GA, with the highest amount in infants 30-33 weeks’ GA at about 2 weeks’ chronologic age. Extreme PB was identified in 76 infants and in 45% was temporally associated with clinical events including infection or necrotizing enterocolitis (NEC), immunizations, or caffeine discontinuation. In 8/28 cases of septicemia and 10/21 cases of NEC there was a >2-fold increase in %PB over baseline in the day prior to diagnosis. Conclusion Infants <35 weeks GA spend, on average, <6% of the time in PB. An acute increase in PB may reflect illness or physiological stressors or may occur without any apparent clinical event.

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“…Also, studies have reported increased cardiorespiratory events in preterm infants after immunizations, which might be related to periodic breathing. Others, however, have not found this association, which may reflect different maturational stages and clinical entities [33][34][35].…”

Section: Immature Breathing Pattern/persistent Apnea Of Prematuritymentioning

confidence: 86%

Sleep related breathing disorders and indications for polysomnography in preterm infants

Joosten

Goederen

Pijpers

et al. 2017

Early Human Development

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There is a range of breathing problems which occur and may persist in preterm infants, such as central apneas, obstructive apneas and periodic breathing. Preterm infants may also suffer from respiratory distress syndrome and chronic lung disease necessitating prolonged use of oxygen therapy after discharge from the hospital. Due to these persistent breathing pattern abnormalities in preterm infants, there is a higher risk of altered sleep and apparent life threatening events. Polysomnography can be a helpful tool to identify those infants who have abnormalities in their breathing pattern, to identify those infants who have an increased risk to get a sleep related breathing event at home and to decide about the discontinuation of oxygen therapy.

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Very low birth weight infants have only few adverse events after timely immunization

Cited by 17 publications

References 17 publications

Adverse Events After Routine Immunization of Extremely Low-Birth-Weight Infants

Adverse Events After Routine Immunization of Extremely Low-Birth-Weight Infants

Clinical associations with immature breathing in preterm infants: part 2—periodic breathing

Sleep related breathing disorders and indications for polysomnography in preterm infants

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