Very low birth weight is associated with brain structure abnormalities and cognitive function impairments: A systematic review

Farajdokht, Fereshteh; Sadigh-Eteghad, Saeed; Dehghani, Reza; Mohaddes, Gisou; Abedi, Leili; Bughchechi, Ramin; Majdi, Alireza; Mahmoudi, Javad

doi:10.1016/j.bandc.2017.07.006

Cited by 34 publications

(28 citation statements)

References 83 publications

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“…It has been proposed that left-handedness has a pathological (46,47) origin in some individuals, resulting from left hemisphere damage during the prenatal or perinatal period. Indeed, lower birthweight increases the risk of perinatal brain injury (48) and is known to have extensive effects on brain development (49), including smaller brain size even in the absence of neonatal focal brain injury (38). The prevalence of left-handedness is elevated in some neurodevelopmental disorders with notable brain alterations, such as autism (50), Down's syndrome (51), and schizophrenia (43).…”

Section: Discussionmentioning

confidence: 99%

Triplets, birthweight, and handedness

Heikkilä

Beijsterveldt

Haukka

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

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The mechanisms behind handedness formation in humans are still poorly understood. Very low birthweight is associated with higher odds of left-handedness, but whether this is due to low birthweight itself or premature birth is unknown. Handedness has also been linked to development, but the role of birthweight behind this association is unclear. Knowing that birthweight is lower in multiple births, triplets being about 1.5 kg lighter in comparison with singletons, and that multiples have a higher prevalence of left-handedness than singletons, we studied the association between birthweight and handedness in two large samples consisting exclusively of triplets from Japan ( = 1,305) and the Netherlands ( = 947). In both samples, left-handers had significantly lower birthweight (Japanese mean = 1,599 g [95% confidence interval (CI): 1,526-1,672 g]; Dutch mean = 1,794 g [95% CI: 1,709-1,879 g]) compared with right-handers (Japanese mean = 1,727 g [95% CI: 1,699-1,755 g]; Dutch mean = 1,903 g [95% CI: 1,867-1,938 g]). Within-family and between-family analyses both suggested that left-handedness is associated with lower birthweight, also when fully controlling for gestational age. Left-handers also had significantly delayed motor development and smaller infant head circumference compared with right-handers, but these associations diluted and became nonsignificant when controlling for birthweight. Our study in triplets provides evidence for the link between low birthweight and left-handedness. Our results also suggest that developmental differences between left- and right-handers are due to a shared etiology associated with low birthweight.

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Section: Discussionmentioning

confidence: 99%

Triplets, birthweight, and handedness

Heikkilä

Beijsterveldt

Haukka

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

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“…Table 1 summarizes common ante-, intra-and postnatal risk factors for the CP development. [25] Cold or flu during the pregnancy (OR равняется 3.464 (CI = 2.144-5.596)) [8,38] Umbilical cord initiation with intrauterine hypoxia development (OR 1.223 (CI = 0.869-1.669)) [11] Multiple pregnancy OR 3.464 (CI = 2.144-5.596), [37,38] Intrauterine infections (TORCH infections), genital tract infections OR 1.381 ( CI = 0.944-2.028) [5] Polyhydramnios and aridity OR 1.586 (CI = 1.011-2.488), [8] Intrauterine hypoxia-ischaemia of the brain, intraventricular and intracerebral hemorrhages, cysts of the brain (OR 2.801 (CI -1.714-4.576) [26,27,30] Inadequate fetal position in uterus (OR 2.629 (CI -0.932-7.411),) […”

Section: Common Risk Factors For Cp Development For High and Low-incomentioning

confidence: 99%

“…In particular, brain hypoxia (oxygen deficiency) and ischemia (insufficient blood supply) can lead to severe neuropathology in preterm and born at term infants, especially with the damage of the white matter of the cerebral dominating in the infants born pretermed, and injury in neouranal in the stage of infants [26]. Injury caused to the developing brain believed to be associated with long-term residuals such as CP, problems with hearing, sight, speech, and behavioral disorders, seizures as well as intellectual disabilities [27].…”

Section: Hypoxia-ischaemiamentioning

confidence: 99%

“…Preterm birth is accepted as a main risk factor for CP, reflected in the fact that over 40% of individuals with CP are born preterm; nonetheless, up to 60% of individuals with CP were born at term [8]. New evidence suggests that around 70% to 80% of the cases of CP depends on antenatal factors, with birth asphyxia playing aapproximately lower role [27]. Moreover, a recent population-based study showed that there is an increased risk of CP associated with racial and socio-economic disadvantages; therefore, the risk of spastic CP was more than 50% higher for Black versus Caucasian race representatives (OR 1.52, 95% CI 1.33-1.73), whereas there was a lower risk of mothers in high education (OR 1.35, 95% CI 1.18-1.55) [29].…”

Section: Pre-term Birthmentioning

confidence: 99%

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Cerebral palsy risk factors: international experience

et al. 2020

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This review article aims to outline several risk factors for the Cerebral Palsy (CP) development worldwide. CP is the most prevalent disabling condition in children that imposes a significant socio-economical responsibility on the system of the health care. Despite a solid body of extant research, the exact etiology of CP remains unknown. There are several risk factors that may be triggering CP development at pre-, intra- and postnatal periods, particularly, gestational age, birth weight, mother's health, placental abnormalities, thrombophillia, asphyxia, brain ischemia and multiple pregnancies. According to extant literature, the majority of CP cases develop within antenatal period in high-income countries. Contrastingly, in developing countries, there is a slightly higher proportion of a postnatally acquired CP cases linked to post-infectious brain damage following meningitis, septicaemia, as well as other conditions, such as malaria. However, these studies were of a small size and not case-controlled or population-based, which significantly curtails the results and underestimating the real picture. With very small number of survivors of early preterm, common risk factors identified to be the maternal rhesus allergenic immunization and birth asphyxia, or hereditary diseases, such as dehydrogenase of glucose-6-phosphate (G6PD) deficiency and encephalopathy of subsequent bilirubin. According to standardized data from international surveillance programs, important risk factors are strongly associated with CP development in most countries.

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“…Kognitive Fähigkeiten stellen eine wichtige Determinante für die Gesundheit in verschiedenen Lebensphasen dar ( [1][2][3]). Sie sind zu 40-80 % [4] genetisch festgelegt, verschiedene Übersichtsarbeiten zeigen jedoch auch frühkindliche Einflussfaktoren auf, die die Variabilität kognitiver Fähigkeiten erklären können, darunter Exposition gegenüber Rauchen während der Schwangerschaft [5], Geburtsgewicht [6,7] und Stillen [8]. Darüber hinaus konnte belegt werden, dass sozioökonomische Faktoren wie die elterliche Bildung [9] und die Ethnizität [10] mit den kognitiven Fähigkeiten der Kinder assoziiert sind.…”

Section: Introductionunclassified

Determinanten der kognitiven Entwicklung bei Kindern – Ergebnisse des Mann-Zeichen-Tests aus der Vorschuluntersuchung

et al. 2020

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Zusammenfassung Ziel der Studie Bestimmung von Determinanten und Einflussfaktoren der Wahrnehmungsentwicklung bzw. der kognitiven Entwicklung anhand des Mann-Zeichen-Tests bei Vorschulkindern. Methodik Datengrundlage bildeten Elternfragebögen, die im Rahmen einer Geburtskohortenstudie (Ersterhebung 2000/2001 in Ulm) eingesetzt wurden mit Folgeerhebungen im zweiten, dritten, vierten und sechsten Lebensjahr. Die kognitive Entwicklung wurde anhand von Zeichnungen von n=298 Kindern anlässlich der Schuleingangsuntersuchung (mittleres Alter=5,8 Jahre, SD=0,4) mithilfe des Mann-Zeichen-Tests gemessen. Bi- und multivariable lineare Regressionsanalysen dienten zur Analyse von möglichen Einflussfaktoren. Ergebnisse Bei Jungen fand sich eine positive Assoziation zwischen der einer hohen Schulbildung des Vaters und der kindlichen kognitiven Entwicklung (Regressionskoeffizient b, p-Wert: 6,65, p=0,018). Tendenziell konnte darüber hinaus ein negativer Zusammenhang des Besuchs eines Kinderhorts (b=− 0,18/Monat, p=0,074) sowie von allergischen Erkrankungen (b=− 6,02, p=0,075) und der kognitiven Entwicklung gezeigt werden. Ein Fernseh-/Videokonsum von mehr als 30 Min./Tag im Alter von 4 Jahren (b=− 9,37, p=0,005) war deutlich negativ mit den kindlichen kognitiven Fähigkeiten assoziiert. Bei Mädchen zeigten sich Hinweise auf eine negative Assoziation zwischen einer hohen mütterlichen Schulbildung (b=− 4,43, p=0,091) sowie eine positive Assoziation zwischen allergischen Erkrankung und der kognitiven Entwicklung (b=6,42, p=0,075). Eine gleichzeitige Adjustierung für alle relevanten Kovariablen führte sowohl bei Jungen als auch bei Mädchen zur Abschwächung der Assoziationen, jedoch blieb bei Jungen der Zusammenhang der väterlichen Bildung und des Fernseh-/Videokonsums mit den kindlichen kognitiven Fähigkeiten bestehen. Schlussfolgerung Die Studie zeigt modifizierbare Faktoren auf, die mit der kognitiven Fähigkeit von Jungen und Mädchen im Alter von 6 Jahren in Zusammenhang stehen, insbesondere der frühkindliche Medienkonsum bei Jungen.

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Very low birth weight is associated with brain structure abnormalities and cognitive function impairments: A systematic review

Cited by 34 publications

References 83 publications

Triplets, birthweight, and handedness

Triplets, birthweight, and handedness

Cerebral palsy risk factors: international experience

Determinanten der kognitiven Entwicklung bei Kindern – Ergebnisse des Mann-Zeichen-Tests aus der Vorschuluntersuchung

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