Very Low-Calorie Ketogenic Diet (VLCKD) as Pre-Operative First-Line Dietary Therapy in Patients with Obesity Who Are Candidates for Bariatric Surgery

Barrea, Luigi; Verde, Ludovica; Schiavo, Luigi; Sarno, Gerardo; Camajani, Elisabetta; Iannelli, Antonio; Caprio, Massimiliano; Pilone, Vincenzo; Colao, Annamaria; Muscogiuri, Giovanna

doi:10.3390/nu15081907

Cited by 8 publications

(2 citation statements)

References 122 publications

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“…Bariatric surgery (BS) as a way of reducing weight for severely obese patients is often conducted when other methods are failed to reduce weight such as diet, exercise, and drugs (Barrea et al., 2023 ; Zebari et al., 2022 ). However, KD can be used as a useful tool for preoperative weight reduction in bariatric surgery especially in short‐time conditions.…”

Section: Resultsmentioning

confidence: 99%

The impact of ketogenic diet on some metabolic and non‐metabolic diseases: Evidence from human and animal model experiments

Galali,

Zebari,

Aj. Jabbar

et al. 2024

Food Science & Nutrition

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The ketogenic diet (KD) is recognized as minimum carbohydrate and maximum fat intakes, which leads to ketosis stimulation, a state that is thought to metabolize fat more than carbohydrates for energy supply. KD has gained more interest in recent years and is for many purposes, including weight loss and managing serious diseases like type 2 diabetes. On the other hand, many believe that KD has safety issues and are uncertain about the health drawbacks. Thus, the outcomes of the effect of KD on metabolic and non‐metabolic disease remain disputable. The current narrative review aims to evaluate the effect of KD on several diseases concerning the human health. To our best knowledge, the first report aims to investigate the efficacy of KD on multiple human health issues including type 2 diabetes and weight loss, cardiovascular disease, kidney failure and hypertension, non‐alcoholic fatty liver, mental problem, oral health, libido, and osteoporosis. The literature searches were performed in Databases, PubMed, Scopus, and web of Science looking for both animal and human model designs. The results heterogeneity seems to be explained by differences in diet composition and duration. Also, the available findings may show that proper control of carbohydrates, a significant reduction in glycemic control and glycated hemoglobin, and weight loss by KD can be an approach to improve diabetes and obesity, hypertension, non‐alcoholic fatty liver, PCOS, libido, oral health, and mental problem if isocaloric is considered. However, for some other diseases like cardiovascular disease and osteoporosis, more robust data are needed. Therefore, there is robust data to support the notion that KD can be effective for some metabolic and non‐metabolic diseases but not for all of them. So they have to be followed cautiously and under the supervision of health professionals.

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Section: Resultsmentioning

confidence: 99%

The impact of ketogenic diet on some metabolic and non‐metabolic diseases: Evidence from human and animal model experiments

Galali,

Zebari,

Aj. Jabbar

et al. 2024

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

“…The daily energy intake is 400–800 kcal, with 30–50 grams of carbohydrates, 20–40 grams of fat, and 1.2–1.4 grams of protein per kilogram of body weight. This type of diet reduces the volume of a fatty liver, visceral fat mass, and perioperative complications in obese individuals [ 45 ].…”

Section: Treatment Options For Metabolic Dysregulation In Patients Wi...mentioning

confidence: 99%

Metabolic dysregulation in obese women and the carcinogenesis of gynecological tumors: A review

Tomić Naglić,

Mandić,

Milankov

et al. 2024

Biomol Biomed

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Obesity is a significant health issue associated with increased cancer risks, including gynecological malignancies. The worldwide rise in obesity rates is significantly impacting both cancer development and treatment outcomes. Adipose tissue plays a crucial role in metabolism, secreting various substances that can influence cancer formation. In obese individuals, dysfunctional adipose tissue can contribute to cancer development through inflammation, insulin resistance, hormonal changes, and abnormal cholesterol metabolism. Studies have shown a strong correlation between obesity and gynecological cancers, particularly endometrial and breast cancers. Obesity not only increases the risk of developing these cancers but is also associated with poorer outcomes. Additionally, obesity affects the perioperative management of gynecological cancers, requiring specialized care due to increased complications and resistance to therapy. Treatment strategies for managing metabolic dysregulation in patients with gynecological cancers include weight management, statin therapy, and insulin-sensitizing medications. Emerging studies suggest that interventions like intermittent fasting and caloric restriction may enhance the effectiveness of cancer treatments. Furthermore, targeting cholesterol metabolism, such as with statins or proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, shows potential in cancer therapy. In conclusion, addressing metabolic issues, particularly obesity, is crucial in preventing and treating gynecological malignancies. Personalized approaches focusing on weight management and metabolic reprogramming may improve outcomes in these patients.

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Very Low Calorie Ketogenic Diet: What Effects on Lipid Metabolism?

Suarez,

Chapela,

Llobera

et al. 2024

Curr Nutr Rep

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Purpose of Review This review aims to critically examine how VLCKD affects plasma lipoprotein, lipid and cholesterol metabolism. Cardiovascular disease is a worldwide health problem affecting millions of people and leading to high rates of mortality and morbidity. There is a well-established association between cardiovascular disease and circulating cholesterol. Various dietary recommendations are currently available for the management of dyslipidemia. Recent Findings The very low-calorie ketogenic diet (VLCKD) is becoming increasingly popular as a treatment option for several pathological conditions, including dyslipidemia. In addition to being low in calories, the VLCKD's main feature is its unique calorie distribution, emphasizing a reduction in carbohydrate consumption in favor of fat as the primary calorie source. Lowering calorie intake through a VLCKD can reduce the endogenous production of cholesterol. However, if the foods consumed are from animal sources, dietary cholesterol intake may increase due to the higher fat content of animal products. When combined, these dietary practices may have opposing effects on plasma cholesterol levels. Summary Studies investigating the impact of VLCKD on plasma cholesterol and low-density lipoprotein cholesterol levels report contradictory findings. While some studies found an increase in low-density lipoprotein cholesterol levels, others showed a decrease in total cholesterol and low-density lipoprotein cholesterol, along with an increase in high-density lipoprotein cholesterol.

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Very Low-Calorie Ketogenic Diet (VLCKD) as Pre-Operative First-Line Dietary Therapy in Patients with Obesity Who Are Candidates for Bariatric Surgery

Cited by 8 publications

References 122 publications

The impact of ketogenic diet on some metabolic and non‐metabolic diseases: Evidence from human and animal model experiments

The impact of ketogenic diet on some metabolic and non‐metabolic diseases: Evidence from human and animal model experiments

Metabolic dysregulation in obese women and the carcinogenesis of gynecological tumors: A review

Very Low Calorie Ketogenic Diet: What Effects on Lipid Metabolism?

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