Very low level environmental exposure to lead and prolactin levels during pregnancy

Takser, Larissa; Mergler, Donna; Lafond, Julie

doi:10.1016/j.ntt.2005.03.009

Cited by 24 publications

(25 citation statements)

References 21 publications

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“…When compared with the previously reported concentrations in cord whole blood in other countries (Table 4) [16][17][18][19][20][21][22][23][24][25][26][27][28][29], higher Se concentration and lower Pb concentration was noted in this study. No clear-cut threshold for Se deficiency has been established, 100 ng/g might be a candidate level because above this level correlation with glutathione peroxidase activity diminishes [30].…”

Section: Se CD and Pb Concentrations In Cord Bloodsupporting

confidence: 62%

Cadmium, Lead, and Selenium in Cord Blood and Thyroid Hormone Status of Newborns

Iijima

Otake

Yoshinaga

et al. 2007

Biol Trace Elem Res

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Cadmium (Cd), lead (Pb), and selenium (Se) concentrations in cord whole blood, sampled from 24 women at the time of delivery in a hospital in Tokyo in 2005, were determined by inductively coupled plasma mass spectrometry with a reaction cell. Signal enhancement caused by nonspectroscopic interference for Se was evident and the standard addition technique was essential for correcting the interference. Median concentration in cord bloods was 0.20 ng/g, 6.7 ng/g (0.67 microg/dL), and 191 ng/g for Cd, Pb and Se, respectively. Lead concentration was lower, whereas Se concentration was higher, than those reported in other countries. The trace element concentration was related to the levels of thyroid stimulating hormone (TSH) and free thyroxin (fT4) in the neonatal blood sampled at 4-6 days postpartum. A significantly negative correlation was observed between Cd concentrations in cord blood and TSH concentration in neonatal blood. The result indicated the possible effect of in utero Cd exposure on thyroid hormone status of newborns and that Cd exposure level should be assessed as a covariate in the survey on the relationship between in utero chemicals (e.g., PCBs) exposure and thyroid hormone status.

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Section: Se CD and Pb Concentrations In Cord Bloodsupporting

confidence: 62%

Cadmium, Lead, and Selenium in Cord Blood and Thyroid Hormone Status of Newborns

Iijima

Otake

Yoshinaga

et al. 2007

Biol Trace Elem Res

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“…While in the US there is a large-scale surveillance effort to track levels of mercury, lead, selenium and copper among older children and adults, the United States Center for Disease Control and Prevention (CDC)’s National Health and Nutrition Examination Survey, there is no routine evaluation of fetal exposures. Recent epidemiology studies among non-Arctic European and North American populations have reported average umbilical cord blood or serum concentrations between 0.5–4.4 μg/L for mercury, 1–15.7 μg/dL for lead, 35–86 μg/L for selenium, and 22–52 μg/dL for copper (Bjornberg et al, 2003; Devereux et al, 2007; Jedrychowski et al, 2007; Jones et al, 2010; Koppen et al, 2009; Lorenzo Alonso et al, 2005; Morrissette et al, 2004; Osman et al, 2000; Palkovicova et al, 2008; Perveen et al, 2002; Rhainds et al, 1999; Schell et al, 2003; Schulpis et al, 2004; Takser et al, 2005; Vahter et al, 2000). …”

Section: Introductionmentioning

confidence: 99%

Body burdens of mercury, lead, selenium and copper among Baltimore newborns

Wells

Jarrett

Lin

et al. 2011

Environmental Research

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Umbilical cord blood or serum concentrations of mercury, lead, selenium and copper were measured with inductively coupled plasma mass spectrometry in a population of 300 infants born Baltimore, Maryland. Geometric mean values were 1.37 μg/L (95% confidence interval: 1.27, 1.48) for mercury; 0.66 μg/dL (95% CI: 0.61, 0.71) for lead; and 38.62 μg/dL (95% CI: 36.73, 40.61) for copper. Mean selenium was 70.10 μg/L (95% CI: 68.69, 70.52). Mercury, selenium and copper levels were within exposure ranges reported among similar populations, whereas the distribution of lead levels was lower than prior reports; only one infant had a cord blood lead above 10 μg/dL. Levels of selenium were significantly correlated with concentrations of lead (Spearman’s ρ = 0.20) and copper (Spearman’s ρ = 0.51). Multivariable analyses identified a number of factors associated with one of more of these exposures. These included: increasing maternal age (increased lead); Asian mothers (increased mercury and lead, decreased selenium and copper); higher umbilical cord serum n-3 fatty acids (increased mercury, selenium and copper), mothers using Medicaid (increased lead); increasing gestational age (increased copper); increasing birthweight (increased selenium); older neighborhood housing stock (increased lead and selenium); and maternal smoking (increased lead). This work provides additional information about contemporary prenatal element exposures and can help identify groups at risk of atypical exposures.

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“…[1][2][3][4][5] Lead is a widespread toxic metal and accumulates inside human tissue, such as in bone, with a half-life time between 6 and 10 years, 4,6,7 and has been associated with many adverse effects such as hypertension, cognitive deficits, hyperthyroidism, osteoporosis, and skeletal diseases. [3][4][5]8 Lead exposure continues to be a major public health problem around the world, and there is an urgent need to find novel compounds for prevention of lead poisoning.…”

Section: Introductionmentioning

confidence: 99%