Very preterm children are at increased risk of reduced processing speed at 5 years of age, predicted by typical complications of prematurity and prenatal smoking

Gnigler, Maria; Neubauer, Vera; Griesmaier, Elke; Zotter, S; Kager, K; Kiechl‐Kohlendorfer, Ursula

doi:10.1111/apa.12859

Cited by 20 publications

(17 citation statements)

References 29 publications

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“…Therefore, identification of children with reduced processing speed is important in order to be able to provide special care and support, as well as to prevent further problems in school performance. 23 Although the fact that our study population came from a single hospital may be a limitation to our study, our results are consistent with populations with similar characteristics, as described above.…”

supporting

confidence: 87%

“…In this population of premature infants, 52% of the mothers had less than 12 years of schooling and 48% were reported as having low socioeconomic status. Gnigler et al 23 In the present study, the average total IQ obtained through the WPPSI-III scale was 86.8 (SD: 12.3), i.e. lower than that found in the studies cited above.…”

contrasting

confidence: 72%

“…13 Bronchopulmonary dysplasia has been identified as a risk factor for several neurocognitive domains including working memory, visual-motor coordination and attention. 23 The clinical complications to which they are exposed, along with the socioeconomic vulnerability accompanying prematurity and low birth weight, predispose these children to changes in motor and cognitive development. …”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that use of dexamethasone may alter the synaptic plasticity of the hippocampus and the formation of associative memory. 29 Gnigler et al 23 found that children with bronchopulmonary dysplasia who received corticosteroid treatment were at higher risk of developing a reduction in processing speed. It is also worth mentioning that children with a history of bronchopulmonary dysplasia frequently have respiratory problems in the first years of life.…”

mentioning

confidence: 99%

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Cognitive performance of premature infants: association between bronchopulmonary dysplasia and cognitive skills. Cross-sectional study

2017

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CONTEXT AND OBJECTIVE: Children born prematurely often have worse cognitive performance than those born at term regarding skills such as memory, attention and processing speed. Bronchopulmonary dysplasia may compromise cognitive development. The aims here were: a) To describe the cognitive performance of preterm infants with very low birth weight; b) To investigate its association with bronchopulmonary dysplasia adjusted for sociodemographic, neonatal and post-neonatal factors. DESIGN AND SETTING: Cross-sectional study developed in a public tertiary-care hospital. METHODS:To evaluate cognition among 112 children, we applied an intelligence scale (Wechsler scale). The average scores for children with and without bronchopulmonary dysplasia were compared across the five domains of the scale. Associations with bronchopulmonary dysplasia were investigated for domains that showed significant differences between the two groups. Associations between exposure and outcome were estimated via multivariate logistic regression. RESULTS: There were no differences in averages for the full-scale intelligence quotient, verbal intelligence quotient, performance intelligence quotient and general language composite domains. The processing speed quotient was the only domain that presented a significant difference between the two groups (P = 0.02). Among the children with bronchopulmonary dysplasia, low full-scale intelligence quotient was observed in 28.1%. In the multivariate analysis, bronchopulmonary dysplasia (odds ratio: 3.1; 95% confidence interval: 1.1-8.7) remained associated with the outcome of processing speed quotient. CONCLUSION: Bronchopulmonary dysplasia was an independent risk factor for alteration of the processing speed quotient.RESUMO CONTEXTO E OBJETIVO: Crianças nascidas prematuras com frequência apresentam pior desempenho cognitivo que as nascidas a termo em habilidades como memória, atenção, velocidade de processamento. A displasia broncopulmonar pode comprometer o desenvolvimento cognitivo. Os objetivos aqui foram: a) Descrever o desempenho cognitivo de crianças nascidas prematuras com muito baixo peso; b) Investigar sua associação com a displasia broncopulmonar ajustada para fatores sócio-demográficos, neonatais e pós-neonatais. TIPO DE ESTUDO E LOCAL: Estudo transversal desenvolvido em hospital público de cuidados terciários. MÉTODOS: Para a avaliação cognitiva de 112 crianças, aplicamos a escala de inteligência (Wechsler scale). Foram comparadas as médias dos escores das crianças com e sem displasia broncopulmonar nos cinco domínios da escala. A associação com a displasia broncopulmonar foi investigada para os domínios que apresentaram diferença significativa entre os dois grupos. A associação entre a exposição e o desfecho foi estimada por regressão logística multivariada. RESULTADOS: Não houve diferença entre as médias dos domínios do quociente de inteligência total, quociente de inteligência verbal, quociente de inteligência de execução e composto de linguagem geral. O quociente de velocidade de p...

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supporting

confidence: 87%

contrasting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Cognitive performance of premature infants: association between bronchopulmonary dysplasia and cognitive skills. Cross-sectional study

2017

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“…In line, preterm-born children in our study did not differ significantly in gestational age, birth weight, and sex distribution from all preterm infants in the survey area. 29 Maternal educational status again was higher in the study group.…”

Section: Study Populationmentioning

confidence: 75%

Aortic Elastic Properties in Preschool Children Born Preterm

Komazec

Posod

Schwienbacher

et al. 2016

ATVB

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Objective-Preterm birth predisposes children to the development of cardiovascular diseases in adulthood. The aim of this study was to characterize elastic properties of the aorta at preschool age and test the hypothesis that prematurity is associated with decreased aortic distensibility and increased stiffness, both of which are predictors of increased cardiovascular risk. Approach and Results-In an observational study of 76 five-to seven-year-old children born at a gestational age <32 weeks and 79 term-born controls, elastic parameters of the ascending and descending abdominal aorta were determined noninvasively by means of M mode echocardiographic tracings and calculated using computerized wall contour analysis. Compared with children born at term, the preterm group showed significantly reduced distensibility and increased stiffness of the descending abdominal aorta. These results remained significant under multivariable adjustment for birth weight z score, maternal smoking in pregnancy, maternal education, family history of cardiovascular disease, breastfeeding, childhood nutrition, and current body mass index z score (multivariable odds ratios and 95% confidence intervals 5.1, 1.7-15.9; P=0.005 and 2.8, 1.0-7.9; P=0.046, respectively). Further adjustment for intravenous lipid therapy attenuated the strength of association. Elastic properties of the ascending aorta did not differ between the 2 study groups. Conclusions-Children

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Frühgeborenennachsorge in Österreich: Etablierung eines nationalen Registers

Konzett

Kiechl‐Kohlendorfer

Simma

et al. 2022

Monatsschr Kinderheilkd

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Very preterm children are at increased risk of reduced processing speed at 5 years of age, predicted by typical complications of prematurity and prenatal smoking

Abstract: More than a third of the very preterm children we tested showed reduced processing speed at 5 years of age, and predictors were typical complications of prematurity and smoking in pregnancy.

Cited by 20 publications

References 29 publications

Cognitive performance of premature infants: association between bronchopulmonary dysplasia and cognitive skills. Cross-sectional study

Cognitive performance of premature infants: association between bronchopulmonary dysplasia and cognitive skills. Cross-sectional study

Aortic Elastic Properties in Preschool Children Born Preterm

Frühgeborenennachsorge in Österreich: Etablierung eines nationalen Registers

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