Very Rare Liver Neoplasm: Lymphoepithelioma-Like (<i>LEL</i>) Hepatocellular Carcinoma

Filotico, Marcello; Moretti, Valentina; Floccari, Federica; D’Amuri, Alessandro

doi:10.1155/2018/2651716

Cited by 9 publications

(11 citation statements)

References 9 publications

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“…The first study [ 50 ] reported a 62-year-old woman who was admitted to the hospital because of right upper abdominal drop pain with hepatitis B. Laboratory examination showed that AFP was 394.90 ng/ml (0–7 ng/ml).…”

Section: Discussionmentioning

confidence: 99%

“…of lesions Size, mm Treatment FU, mo. Outcome Immunohistochemical markers AFP Hepatocyte CK7 CK19 CK18 EBER First case M 62 Asian + – + 1 28 LR 13 AWOD – + + + + – Filotico et al [ 50 ] F 62 NA + – + 1 50 LR NA NA + + + + NA NA Wei et al [ 51 ] M 40 Asian + – + 1 21 LR 30 AWOD – + + + + – F female, M male, + positive, − negative, HBV hepatitis B virus, HCV hepatitis C virus, NA not available, No . number, AFP a-fetoprotein, AWOD alive without disease, FU follow-up, mo .…”

Section: Discussionmentioning

confidence: 99%

“…The clinical manifestations of LELC patients are not special. Most patients have physical examination findings, and some of them have right upper abdominal pain or chronic cholecystitis symptoms [ 16 , 21 , 50 ]. Nonetheless, because of its nonspecific clinical manifestations, it is difficult to diagnose LELC before surgery.…”

Section: Discussionmentioning

confidence: 99%

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Lymphoepithelioma-like carcinoma in liver not associated with Epstein-Barr virus: a report of 3 cases and literature review

Zhang

Tao

et al. 2020

Diagn Pathol

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Background Lymphoepithelioma-like carcinoma is a rare distinctive variant of liver cancer with unique epidemiological and pathological characteristics, characterized by dense lymphocyte infiltration. It can be divided into lymphoepithelioma-like hepatocellular carcinoma and lymphoepithelioma-like intrahepatic cholangiocarcinoma. Existing research shows that the prognosis of this tumor is good. To date, only 101 cases have been reported. Case presentation The first patient was a 62-year-old Chinese man with hepatitis B virus infection who presented with a single lesion in the liver. The patient underwent surgical treatment and was discharged on the 4th day. The patient was diagnosed with combined lymphoepithelioma-like hepatocellular carcinoma and cholangiocarcinoma; he has been alive for 15 months. The second patient was a 63-year-old Chinese woman with right upper abdominal pain and hepatitis B virus infection. The imaging examination revealed a single lesion in the liver. The patient underwent surgical treatment and was discharged 1 week later. The patient was diagnosed with lymphoepithelioma-like hepatocellular carcinoma and was considered to have recurrence in the lymph nodes approximately 2 years after the operation. The patient underwent local radiotherapy; she has been alive for 60 months. The third patient was a 50-year-old Chinese man with hepatitis B virus infection who presented with a single lesion in the liver and two enlarged lymph nodes. The patient received liver puncture before surgery to indicate lymph node metastasis and experienced local recurrence after liver resection. The patient underwent chemotherapy and radiotherapy. The patient was diagnosed with lymphoepithelioma-like hepatocellular carcinoma. The patient was deceased at 24-month follow-up. Conclusions This article reports 3 cases without Epstein-Barr virus and reviews the current literature, which suggests even mixed pathological type or locally advanced cases of LELC with lymph node metastasis and postoperative recurrence should be actively treated for a longer survival period.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Lymphoepithelioma-like carcinoma in liver not associated with Epstein-Barr virus: a report of 3 cases and literature review

Zhang

Tao

et al. 2020

Diagn Pathol

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“…The first literature [50] reported a 62 years old woman who was admitted to the hospital because of the right upper abdominal drop pain with hepatitis B.Laboratory examination showed that AFP:…”

Section: Discussionmentioning

confidence: 99%

“…In the future, more research and reports are needed to improve this special pathological type. [19,23,50] . Because of its nonspecific clinical manifestations, it is difficult to diagnose LELC before operation.…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-like hepatic carcinoma: A report of 3 cases and review of the literature

Zhang

Tao

et al. 2020

Preprint

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Background: Lymphoepithelioma-like hepatic carcinoma is a rare distinctive variant of liver cancer with unique epidemiological and pathological characteristics, characterized by dense lymphocyte infiltration. It can be divided into lymphoepithelioma-like hepatocellular carcinoma and lymphoepithelioma-like intrahepatic cholangiocarcinoma. Existing research shows that its prognosis is good. Up to now, only 101 cases have been reported. More rarely, combined lymphoepithelioma-like hepatocellular carcinoma and cholangiocarcinoma has been found. Case presentation: The first patient was a 62 years old Chinese man with hepatitis B virus infection presented with a single lesion in the liver. The patient underwent surgical treatment and was discharged on the 4th day. The patient was diagnosed as combined lymphoepithelioma-like hepatocellular carcinoma and cholangiocarcinoma and has been alive for 15 months. The second patient was a 63 years old Chinese woman with right upper abdominal pain and hepatitis B virus infection. The imaging examination a single lesion in the liver. The patient underwent surgical treatment and was discharged one week later. The patient was diagnosed as lymphoepithelioma-like hepatocellular carcinoma and was considered to be the recurrence of lymph nodes about 2 years after operation. The patient underwent local radiotherapy and has been alive for 60 months. The third patient was a 50 years old Chinese man with hepatitis B virus infection presented with a single lesion in the liver and two enlarged lymph nodes. The patient received liver puncture before operation to indicate lymph node metastasis and had local recurrence after liver resection. The patient underwent chemotherapy and radiotherapy. The patient was diagnosed as lymphoepithelioma-like hepatocellular carcinoma. Finally, the patient died at 24 months follow-up. Conclusions: This article reports 3 cases of LELC and reviews the current research discovery, which suggests that even the locally advanced patients of LELC with postoperative recurrence and preoperative lymph node metastasis should be actively treated and intervened for a longer survival period. Keywords: Liver Cancer, Lymphoepithelioma-like carcinoma, Hepatocellular carcinoma, Cholangiocarcinoma

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Programmed cell death ligand 1 expression in a case of poorly differentiated lymphocyte‐rich hepatocellular carcinoma

Omori

Osuga

Miyanishi

et al. 2021

Clinical Case Reports

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Very Rare Liver Neoplasm: Lymphoepithelioma-Like (LEL) Hepatocellular Carcinoma

Cited by 9 publications

References 9 publications

Lymphoepithelioma-like carcinoma in liver not associated with Epstein-Barr virus: a report of 3 cases and literature review

Lymphoepithelioma-like carcinoma in liver not associated with Epstein-Barr virus: a report of 3 cases and literature review

Lymphoepithelioma-like hepatic carcinoma: A report of 3 cases and review of the literature

Programmed cell death ligand 1 expression in a case of poorly differentiated lymphocyte‐rich hepatocellular carcinoma

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