Verzögerte Kohlenmonoxidenzephalopathie

Abstract

Carbon monoxide poisoning is a very common intoxication worldwide. Its clinical manifestations vary from symptoms like mild headache and dizziness to more serious issues including death. Less well known are symptoms that occur with a delay of 2-40 days, such as movement disorders, cognitive impairment or affective disorders. In this article, we present a case of carbon monoxide poisoning with a delayed neurological sequela. The following review summarizes the literature on clinical presentation, diagnostic options, pathophysiology and therapy of this disease.

Role of serum erythropoietin level in evaluating severity of tissue hypoxia in carbon monoxide intoxicated patients.

“…In this study, there was a significant affection for brain CT in CO-poisoned patients in all groups; this was explained by Lettow et al (2018) who reported that the mechanism of action of carbon monoxide on the brain was inhibition of oxidative phosphorylation in mitochondria, which led to ischemic injury in the brain, in addition, Carbon monoxide poisoning resulted in the displacement of NO from hemo-containing proteins in platelets and stimulation of guanylate cyclase enzyme which led to increasing brain perfusion and brain edema.…”

Kohlenmonoxid – ein unterschätztes Risiko? Bekanntheit, Wahrnehmung, Wissen und Präventionsverhalten

“…So liegt beispielsweise die Latenz einer toxischen Enzephalopathie bei 2 bis 40 Tagen. Sie kommt bei 10-20 % der Betroffenen vor und äußert sich wesentlich durch Angst-und Bewegungsstörungen (Parkinsonismus; [28]). Daher sollten CO-spezifische Risikoinformationen auf diese äußerst schmerzhaften Symptome sowie mögliche neuropsychiatrische Spätfolgen hinweisen.…”